Patents by Inventor Mario E Lozanov

Mario E Lozanov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9346743
    Abstract: This invention provides a method for the synthesis of a 2-amino-4,6-dimethoxybenzamide and other benzamides of Compound I: wherein R1, R2, R3, and R4 each independently represent a hydrogen, a C1-C6 alkyl, or a C1-C6 alkoxy; and wherein R6 and R7 each independently represent a hydrogen, a C1-C6 alkyl, a protecting group, or a directing group.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: May 24, 2016
    Assignee: Albemarle Corporation
    Inventors: Amit Thakkar, Andrew G. Zeiler, Anthony F. Skufca, James J. Springer, Bryce Kelly Assink, Mario E. Lozanov
  • Publication number: 20160102046
    Abstract: This invention provides a method for the synthesis of a 2-amino-4,6-dimethoxybenzamide and other benzamides of Compound I: wherein R1, R2, R3, and R4 each independently represent a hydrogen, a C1-C6 alkyl, or a C1-C6 alkoxy; and wherein R6 and R7 each independently represent a hydrogen, a C1-C6 alkyl, a protecting group, or a directing group.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 14, 2016
    Applicant: ALBEMARLE CORPORATION
    Inventors: Amit THAKKAR, Andrew G. Zeiler, Anthony F. SKUFCA, James J. SPRINGER, Bryce Kelly ASSINK, Mario E. LOZANOV
  • Patent number: 7067676
    Abstract: The present invention provides methods for the efficient preparation of indole derivatives of the formula wherein X is methyl or benzyl; and R1, R2, R3 and R4 are independently hydrogen, halogen, cyano, nitro, hydroxy, optionally substituted alkyl, alkoxy, aralkoxy, carboxy, alkoxycarbonyl, aryl or heteroaryl; or R1 and R2 combined together with the carbon atoms to which they are attached form a fused 6-membered aromatic ring; by reacting indoles of the formula wherein R1, R2, R3 and R4 have meanings as defined for formula I, with dimethyl carbonate when X is methyl, or with dibenzyl carbonate when X is benzyl, in the presence of a catalytic amount of a base at an ambient temperature to afford compounds of formula I wherein X, R1, R2, R3 and R4 have meanings as defined herein above. In particular, the present invention provides methylation and benzylation of the indole nitrogen in nearly quantitative yields using 1,4-diazabicyclo[2.2.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: June 27, 2006
    Assignee: Novartis AG
    Inventors: Steven Dell, Mario E Lozanov, Wen-Chung Shieh