Patents by Inventor Mario Feola

Mario Feola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating acute blood loss
    Publication number: 20070270333
    Abstract: The present invention relates to novel methods of using blood substitutes to treat acute blood loss and novel pharmaceutical compositions comprising blood substitutes. Blood substitutes useful for the methods of the present invention can (1) induce expression of erythropoietin as tested in a cell culture under normoxic conditions, and/or (2) induce erythropoiesis under normoxic conditions as measured by (a) a decrease in the doubling time of the subject's hematocrit or hemoglobin, and/or (b) an increase in the subject's circulating erythropoietin level. Blood substitutes useful for the pharmaceutical compositions of the present invention can (1) stabilize HIF-1 alpha expression, and/or (2) down regulate NF-kappa B.
    Type: Application
    Filed: May 16, 2006
    Publication date: November 22, 2007
    Inventors: Jan Simoni, Grace Simoni, Mario Feola
  • Ultra pure hemoglobin solutions and blood-substitutes
    Patent number: 6506725
    Abstract: A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood, separating out a stromal-free, sterile hemoglobulin solution, chromatographically separating endotoxins from said hemoglobin solution and crosslinking the resulting endotoxin-free hemoglobin solution.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: January 14, 2003
    Assignee: BioPure Corporation
    Inventors: Carl W. Rausch, Mario Feola
  • Ultra pure hemoglobin solutions and blood substitutes
    Patent number: 5905141
    Abstract: A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood, separating out a stromal-free, sterile hemoglobin solution, chromatographically separating endotoxins from said hemoglobin solution and crosslinking the resulting endotoxin-free hemoglobin solution.
    Type: Grant
    Filed: April 8, 1997
    Date of Patent: May 18, 1999
    Assignee: Biopure Corporation
    Inventors: Carl W. Rausch, Mario Feola
  • Ultra pure hemoglobin solutions and blood-substitutes
    Patent number: 5618919
    Abstract: A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood, separating out a stromal-free, sterile hemoglobin solution, chromatographically separating endotoxins from said hemoglobin solution and crosslinking the resulting endotoxin-free hemoglobin solution.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: April 8, 1997
    Assignee: Biopure Corportion
    Inventors: Carl W. Rausch, Mario Feola
  • Blood substitute
    Patent number: 5439882
    Abstract: An improved blood substitute comprises purified hemoglobin, preferably bovine, cross-linked intramolecularly with periodate-oxidized ATP (o-ATP) and intermolecularly with periodate-oxidized adenosine (o-adenosine), combined with reduced glutathione (GSH), and optionally enriched with mannitol, non-electrolytes, and/or electrolytes. The blood substitute has prolonged intravascular persistence, can sustain plasma volume, has low oxygen affinity, can work as a physiological oxygen carrier, has vasodilator activity and can reduce the vasoconstriction that follows hemorrhage. A method of treating a human afflicted with acute blood loss and/or a sickling crisis of sickle cell anemia comprises intravenously administrating to the human an effective volume of the blood substitute.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: August 8, 1995
    Assignee: Texas Tech University Health Sciences Center
    Inventors: Mario Feola, Jan S. Simoni, Peter C. Canizaro, deceased
  • Ultra pure hemoglobin solutions and blood-substitutes
    Patent number: 5296465
    Abstract: A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood, separating out a stromal-free, sterile hemoglobin solution, chromatographically separating endotoxins from said hemoglobin solution and crosslinking the resulting endotoxin-free hemoglobin solution.
    Type: Grant
    Filed: January 13, 1992
    Date of Patent: March 22, 1994
    Assignee: Biopure Corporation
    Inventors: Carl W. Rausch, Mario Feola
  • Extra pure semi-synthetic blood substitute
    Patent number: 5084558
    Abstract: A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free homoglobin solution and process for preparing same. The process comprises fractionating whole blood, separating out a stromal-free, sterile hemoglobin solution, chromatographically separating endotoxins from said hemoglobin solution and crosslinking the resulting endotoxin-free hemoglobin solution.
    Type: Grant
    Filed: November 10, 1987
    Date of Patent: January 28, 1992
    Assignee: Biopure Corporation
    Inventors: Carl W. Rausch, Mario Feola