Patents by Inventor Mario Giannini

Mario Giannini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the separation of optical isomers of racemic 1-pyridyl-alkyl-4-aryl piperazines, and optical isomers obtained thereby
    Patent number: 4692525
    Abstract: A process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines, in the racemic form, of the formula ##STR1## in which: the pyridine ring is alpha-, beta-, or gamma-substituted;R=H; C.sub.n H.sub.2n+1, n being in the range from 1 to 4;R'=H, halogen, CH.sub.3, OCH.sub.3,in which process:(a) pyridine aldehyde is reacted between -5.degree. C. and 0.degree. C. with (CH.sub.3).sub.2 S=CH.sub.2 ;(b) the oxirane so obtained is treated with an arylpiperzazine;(c) the hydroxyl derivative obtained in (b), after salification with alkalien hydrides or hydrates in a solvent medium is treated with alkylating agents, and the separation of the compounds so obtained into the respective optical antipodes.
    Type: Grant
    Filed: December 11, 1985
    Date of Patent: September 8, 1987
    Assignee: Malesci S.p.A. Istituto Farmacobiologico
    Inventors: Graziano Bonacchi, Mauro Fedi, Mario Giannini
  • Process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines which are useful as antihypertensive compounds, their separation into the respective optical antipodes, and the stereoisomeric compounds so obtained
    Patent number: 4578467
    Abstract: A process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines, in the racemic form, of the formula ##STR1## in which: the pyridine ring is alpha-, beta-, or gamma-substituted;R=H; C.sub.n H.sub.2n+1, n being in the range from 1 to 4;R'=H, halogen, CH.sub.3, OCH.sub.3,in which process:(a) pyridine aldehyde is reacted between -5.degree. C. and 0.degree. C. with (CH.sub.3).sub.2 S=CH.sub.2 ;(b) the oxirane so obtained is treated with an arylpiperazine;(c) the hydroxyl derivative obtained in (b), after salification with alkaline hydrides or hydrates in a solvent medium is treated with alkylating agents,and the separation of the compounds so obtained into the respective optical antipodes.
    Type: Grant
    Filed: July 3, 1984
    Date of Patent: March 25, 1986
    Assignee: Malesci S.p.A. Instituto Farmacobiologico
    Inventors: Graziano Bonacchi, Mauro Fedi, Mario Giannini