Patents by Inventor Mario Gorziglia

Mario Gorziglia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070010016
    Abstract: Methods and compositions for transducing tumor cells using adenoviral vectors which comprise: a chimeric or modified adenovirus fiber protein and the coding sequence for a therapeutic agent, are provided. The chimeric or modified adenovirus fiber protein has at least a portion of an adenovirus fiber shaft of a first serotype and at least a portion of an adenovirus fiber head of a second serotype wherein the adenovirus comprising such a chimeric or modified adenovirus fiber protein exhibits enhanced transduction of tumor cells.
    Type: Application
    Filed: March 9, 2006
    Publication date: January 11, 2007
    Inventors: Alan McCelland, Susan Stevenson, Mario Gorziglia, Elio Vanin
  • Patent number: 7109029
    Abstract: The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence into a vector construct, such as for example a termination signal sequence upstream of the transcription initiation site of the respective transcription unit.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: September 19, 2006
    Assignee: Cell Genesys, Inc.
    Inventors: Lori Clarke, Mario Gorziglia, Paul L. Hallenbeck, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps
  • Publication number: 20040175364
    Abstract: A method of transferring at least one DNA sequence into cells by transducing the cells, in vivo or ex vivo, with a modified adenovirus. The adenovirus, prior to modification, is of a first serotype. In the modified adenovirus, at least a portion of the fiber, and in particular the head portion, is removed from the adenovirus of the first serotype and replaced with a portion, in particular the head portion, of the fiber of an adenovirus of a second serotype. Such method is useful in transducing cells which may be refractory to the adenovirus of the first serotype, yet include a receptor which binds to the head portion of the fiber of the adenovirus of the second serotype.
    Type: Application
    Filed: April 1, 2004
    Publication date: September 9, 2004
    Inventors: Alan McClelland, Susan C. Stevenson, Mario Gorziglia, Elio F. Vanin
  • Publication number: 20030104624
    Abstract: The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence into a vector construct, such as for example a termination signal sequence upstream of the transcription initiation site of the respective transcription unit.
    Type: Application
    Filed: February 22, 2002
    Publication date: June 5, 2003
    Inventors: Lori Clarke, Mario Gorziglia, Paul L. Hallenbeck, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps
  • Publication number: 20030104625
    Abstract: The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order: A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.
    Type: Application
    Filed: February 22, 2002
    Publication date: June 5, 2003
    Inventors: Cheng Cheng, Lori Clarke, Sheila Connelly, David Leonard Ennist, Suzanne Forry-Schaudies, Mario Gorziglia, Paul L. Hallenbeck, Carl M. Hay, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps, Seshidhar Reddy Police, Patricia Clare Ryan, David A. Stewart, Yuefeng Xie
  • Publication number: 20020192187
    Abstract: A method of transferring at least one DNA sequence into cells by transducing the cells, in vivo or ex vivo, with a modified adenovirus. The adenovirus, prior to modification, is of a first serotype. In the modified adenovirus, at least a portion of the fiber, and in particular the head portion, is removed from the adenovirus of the first serotype and replaced with a portion, in particular the head portion, of the fiber of an adenovirus of a second serotype. Such method is useful in transducing cells which may be refractory to the adenovirus of the first serotype, yet include a receptor which binds to the head portion of the fiber of the adenovirus of the second serotype.
    Type: Application
    Filed: March 11, 2002
    Publication date: December 19, 2002
    Inventors: Alan McClelland, Susan C. Stevenson, Mario Gorziglia, Elio F. Vanin
  • Publication number: 20020123147
    Abstract: A method of transferring at least one DNA sequence into cells by transducing the cells, in vivo or ex vivo, with a modified adenovirus. The adenovirus, prior to modification, is of a first serotype. In the modified adenovirus, at least a portion of the fiber, and in particular the head portion, is removed from the adenovirus of the first serotype and replaced with a portion, in particular the head portion, of the fiber of an adenovirus of a second serotype. Such method is useful in transducing cells which may be refractory to the adenovirus of the first serotype, yet include a receptor which binds to the head portion of the fiber of the adenovirus of the second serotype.
    Type: Application
    Filed: November 27, 2001
    Publication date: September 5, 2002
    Applicant: GENETIC THERAPY, INC.
    Inventors: Alan McClelland, Susan C. Stevenson, Mario Gorziglia, Elio F. Vanin
  • Patent number: 4927628
    Abstract: A new method for producing live, attenuated rotavirus strains suitable for preparing a vaccine is described. It is demonstrated that a naturally attenuated rotavirus recovered from newborns or other individuals whos have undergone asymptomatic infection can be used for immunization or that a virulent rotavirus can be converted into an attenuated strain by substituting the conserved fourth rotavirus gene segments of a naturally attenuated rotavirus in the genome of the virulent rotavirus.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: May 22, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert M. Chanock, Albert Kapikian, Karen Midthun, Jorge Flores, Mario Gorziglia, Yasutaka Hoshino, Irene Peres-Schael