Patents by Inventor Mario Iobbi

Mario Iobbi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180092741
    Abstract: A prosthetic heart valve has three cusp regions positioned at an inflow end intermediate three commissure regions positioned at an outflow end thereof. A support frame including three cusp positioners is fixed with respect to a leaflet frame and located intermediate each pair of adjacent commissure regions. The valve is desirably compressible. In the aortic valve position, the cusp positioners angle outward into contact with the sinus cavities, and compress the native leaflets if they are not excised, or the aortic wall if they are.
    Type: Application
    Filed: December 5, 2017
    Publication date: April 5, 2018
    Inventor: Mario Iobbi
  • Publication number: 20170296333
    Abstract: A prosthetic heart valve includes a collapsible and expandable support frame extending between an inflow end and an outflow end and a plurality of commissures, wherein each commis sure is formed with an elongate opening. A plurality of leaflets are supported inside the support structure and operative for allowing flow in a first direction from the inflow end to the outflow end and to substantially block flow in an opposite direction from the outflow end to the inflow end. Each of the plurality of leaflets includes tabs. The prosthetic heart valve includes at least a first panel of fabric covering the opening of a first commissure. The first panel of fabric is attached to a first tab of a first leaflet via a suture extending orthogonal to the first panel of fabric, wherein the first panel of fabric is positioned radially outwardly of the first tab.
    Type: Application
    Filed: July 5, 2017
    Publication date: October 19, 2017
    Applicant: Edwards Lifesciences Corporation
    Inventor: Mario Iobbi
  • Patent number: 9675455
    Abstract: A prosthetic heart valve having an internal support frame with a continuous, undulating leaflet frame defined therein. The leaflet frame has three cusp regions positioned at an inflow end intermediate three commissure regions positioned at an outflow end thereof. The leaflet frame may be cloth covered and flexible leaflets attached thereto form occluding surfaces of the valve. The support frame further includes three cusp positioners rigidly fixed with respect to the leaflet frame and located at the outflow end of the support frame intermediate each pair of adjacent commissure regions. The valve is desirably compressible so as to be delivered in a minimally invasive manner through a catheter to the site of implantation. Upon expulsion from catheter, the valve expands into contact with the surrounding native valve annulus and is anchored in place without the use of sutures.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: June 13, 2017
    Assignee: Edwards Lifesciences Corporation
    Inventor: Mario Iobbi
  • Patent number: 9504567
    Abstract: A method of implanting a collapsible prosthetic heart valve is disclosed. The prosthetic heart valve includes three biological leaflets mounted within a self-expanding tubular leaflet frame formed of nitinol. The method comprises loading a collapsed prosthetic heart valve into a distal end of a delivery tube. The distal end of the delivery tube is inserted into a vasculature of a patient and positioned proximal to an aortic valve. The prosthetic heart valve is expelled into an annulus of the aortic valve and expanded. The prosthetic heart valve includes cusp positioners that engage sinus cavities above the valve annulus and rotationally orient the prosthetic valve. Preferred embodiments of the cusp positioners do not occlude the coronary arteries.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: November 29, 2016
    Assignee: Edwards Lifesciences Corporation
    Inventor: Mario Iobbi
  • Publication number: 20160338827
    Abstract: A prosthetic heart valve having an internal support frame with a continuous, undulating leaflet frame defined therein. The leaflet frame has three cusp regions positioned at an inflow end intermediate three commissure regions positioned at an outflow end thereof. The leaflet frame may be cloth covered and flexible leaflets attached thereto form occluding surfaces of the valve. The support frame further includes three cusp positioners rigidly fixed with respect to the leaflet frame and located at the outflow end of the support frame intermediate each pair of adjacent commissure regions. The valve is desirably compressible so as to be delivered in a minimally invasive manner through a catheter to the site of implantation. Upon expulsion from catheter, the valve expands into contact with the surrounding native valve annulus and is anchored in place without the use of sutures.
    Type: Application
    Filed: April 25, 2016
    Publication date: November 24, 2016
    Applicant: Edwards Lifesciences Corporation
    Inventor: Mario Iobbi
  • Publication number: 20160184094
    Abstract: A prosthetic heart valve having an internal support frame with a continuous, undulating leaflet frame defined therein. The leaflet frame has three cusp regions positioned at an inflow end intermediate three commissure regions positioned at an outflow end thereof. The leaflet frame may be cloth covered and flexible leaflets attached thereto form occluding surfaces of the valve. The support frame further includes three cusp positioners rigidly fixed with respect to the leaflet frame and located at the outflow end of the support frame intermediate each pair of adjacent commissure regions. The valve is desirably compressible so as to be delivered in a minimally invasive manner through a catheter to the site of implantation. Upon expulsion from catheter, the valve expands into contact with the surrounding native valve annulus and is anchored in place without the use of sutures.
    Type: Application
    Filed: March 4, 2016
    Publication date: June 30, 2016
    Applicant: Edwards Lifesciences Corporation
    Inventor: Mario Iobbi
  • Patent number: 9320598
    Abstract: A method of implanting a collapsible prosthetic heart valve is disclosed. The prosthetic heart valve includes three biological leaflets mounted within a self-expanding tubular leaflet frame formed of nitinol. The method comprises loading a collapsed prosthetic heart valve into a distal end of a delivery tube. The distal end of the delivery tube is inserted into a vasculature of a patient and positioned proximal to an aortic valve. The prosthetic heart valve is expelled into an annulus of the aortic valve and allowed to self-expand to a first diameter. A balloon is then inflated within the prosthetic heart valve for expanding the prosthetic heart valve to a second diameter, wherein the second diameter is larger than the first diameter, thereby securely implanting the prosthetic heart valve within the annulus of the aortic valve.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: April 26, 2016
    Assignee: Edwards Lifesciences Corporation
    Inventor: Mario Iobbi
  • Publication number: 20120290078
    Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a tubular delivery sleeve. The valve catheter has a distal end coupled to a mop. The mop comprises a plurality of flexible extensions configured for releasable attachment to the prosthetic valve. A lead screw nut is coupled to a proximal end of the tubular delivery sleeve and a lead screw is coupled to the valve catheter. The lead screw engages the lead screw nut and rotation of the lead screw causes the delivery sleeve to retract relative to the valve catheter and the prosthetic valve for exposing the prosthetic valve. The flexible extensions of the mop allow expansion of the valve while maintaining the attachment during placement of the valve at a native valve site.
    Type: Application
    Filed: April 17, 2012
    Publication date: November 15, 2012
    Applicant: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Iobbi, Rajesh Khanna, Dave J. Evans
  • Patent number: 8167932
    Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. In one embodiment, the delivery sleeve is retracted by the use of a lead screw, which effectuates relative movement between the valve catheter and delivery sleeve. The prosthetic valve is preferably self-expandable. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: May 1, 2012
    Assignee: Edwards Lifesciences Corporation
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Iobbi, Rajesh Khanna, Dave J. Evans
  • Publication number: 20100121314
    Abstract: A drug delivery device for regulating delivery of a drug to a patient (105) provides a controlled rate of delivery which accounts for changes in health or required dose and, in systems with inherent lag, enables a rapid and accurate response whilst maintaining system stability. The device comprises a drug delivery or dose regulator (103); a sensor (107) for measuring a biochemical or physiological property associated with the drug or the condition to be treated; and a controller (109) configured to control the rate of delivery or dose of drug via the regulator in response to the difference in a measured biochemical or physiological property with respect to a target. In order to maintain the system stability, the controller comprises an anti-wind up component (225) for minimizing wind up effects, and/or a filter sub-component (231) to ensure that the controller does not generate output signals to control the regulator in response to noise or erroneous signals.
    Type: Application
    Filed: October 8, 2007
    Publication date: May 13, 2010
    Inventor: Mario Iobbi
  • Publication number: 20090050152
    Abstract: Device and method for limiting adverse events during supplemental oxygen therapy are disclosed. In the present invention, the oxygen flow between a patient and an oxygen source is controlled with a valve such as a proportional solenoid capable of constraining flow-rates within a continuous range. The flow-rate of oxygen is accurately controlled in a closed-loop with flow-rate measurements. Measures of a patient's vital physiological statistics are used to automatically determine optimum therapeutic oxygen flow-rate. Controller signal filtering is disclosed to improve the overall response and stability. The control algorithm varies flow-rates to minimize disturbances in the patient feedback measurements.
    Type: Application
    Filed: April 12, 2006
    Publication date: February 26, 2009
    Inventor: Mario Iobbi
  • Publication number: 20070088431
    Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. In one embodiment, the delivery sleeve is retracted by the use of a lead screw, which effectuates relative movement between the valve catheter and delivery sleeve. The prosthetic valve is preferably self-expandable. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve.
    Type: Application
    Filed: October 18, 2005
    Publication date: April 19, 2007
    Inventors: Henry Bourang, Thanh Le, David Taylor, Sam Sok, Mario Iobbi, Rajesh Khanna, Dave Evans
  • Publication number: 20060225737
    Abstract: Device and method for limiting adverse events during supplemental oxygen therapy are disclosed. In the present invention, the oxygen flow between a patient and an oxygen source is controlled with a valve such as a proportional solenoid capable of constraining flow-rates within a continuous range. The flow-rate of oxygen is accurately controlled in a closed-loop with flow-rate measurements. Measures of a patient's vital physiological statistics are used to automatically determine optimum therapeutic oxygen flow-rate. Controller signal filtering is disclosed to improve the overall response and stability. The control algorithm varies flow-rates to minimize disturbances in the patient feedback measurements.
    Type: Application
    Filed: April 12, 2005
    Publication date: October 12, 2006
    Inventor: Mario Iobbi