Patents by Inventor Mario Klein
Mario Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240109976Abstract: The present invention relates to combination therapies employing anti-CD20/anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists, in particular 4-1 BBL trimer containing antigen binding molecules, the use of these combination therapies for the treatment of cancer and methods of using the combination therapies.Type: ApplicationFiled: June 13, 2023Publication date: April 4, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Marina Bacac, Claudia Ferrera Koller, Christian Klein, Mario Perro, Johannes Sam, Pablo Umaña, Wei Xu
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Publication number: 20240092856Abstract: The present invention relates to the combination therapy of specific PD-1-targeted IL-2 variant immunoconjugates with specific antibodies which bind human FAP and 4-1BB and optionally with an anti-CEA/anti-CD3 bispecific antibody.Type: ApplicationFiled: March 8, 2022Publication date: March 21, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Marina BACAC, Christina CLAUS, Laura CODARRI DEAK, Sara COLOMBETTI, Christian KLEIN, Valeria G. NICOLINI, Mario PERRO, Johannes SAM, Christine TRUMPFHELLER, Pablo UMAÑA
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Patent number: 6893093Abstract: In the case of a locking device (11) for a vehicle seat, in particular for a motor vehicle seat, having a pivotably mounted locking element (15), a counterpart element (18) which interacts with the locking element (15), a pivotably mounted, spring-loaded clamping eccentric (21) which acts on the locking element (15) and keeps the latter in engagement with the counterpart element (18) in a normal situation, and an intercepting component (25) which is coupled to the clamping eccentric (21) and supports the locking element (15) in a crash situation, a stop (35) which is assigned to the locking element (15) is provided for interaction with the clamping eccentric (21) in a crash situation.Type: GrantFiled: July 14, 2004Date of Patent: May 17, 2005Assignee: KEIPER GmbH & Co. KGInventors: Eckhard Nock, Richard Hänsel, Mario Klein, Martin Kraus
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Patent number: 6840579Abstract: In an unlocking device (21) in a vehicle seat, in particular an automobile seat, which is adapted for unlocking an adjuster or seat mounting (5), the unlocking device (21) comprises an unlocking element (27) extending into the adjuster or seat mounting (5), with the unlocking element (27) being mounted on a pivotally supported entrainment member (25) arranged on the outside of the adjuster or seat mounting (5).Type: GrantFiled: September 4, 2002Date of Patent: January 11, 2005Assignee: Keiper GmbH & Co.Inventors: Mario Klein, Eckhard Nock, Richard Hänsel, Martin Kraus
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Publication number: 20040245816Abstract: In the case of a locking device (11) for a vehicle seat, in particular for a motor vehicle seat, having a pivotably mounted locking element (15), a counterpart element (18) which interacts with the locking element (15), a pivotably mounted, spring-loaded clamping eccentric (21) which acts on the locking element (15) and keeps the latter in engagement with the counterpart element (18) in a normal situation, and an intercepting component (25) which is coupled to the clamping eccentric (21) and supports the locking element (15) in a crash situation, a stop (35) which is assigned to the locking element (15) is provided for interaction with the clamping eccentric (21) in a crash situation.Type: ApplicationFiled: July 14, 2004Publication date: December 9, 2004Applicant: KEIPER GmbH & Co. KGInventors: Eckhard Nock, Richard Hansel, Mario Klein, Martin Kraus
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Publication number: 20040075325Abstract: In a fitting for a vehicle seat, particularly a motor vehicle seat, having a first fitting part (7), a second fitting part (8) pivotable relative to the first fitting part around an axis (A) defined by a bearing shaft (10), also having a compensation spring (12) acting between the first fitting part (7) and the second fitting part (8) through pretension, the compensation spring (12) bears, on the one hand, against the first fitting part (7) and, on the other hand, against a bearing component (20) of the second fitting part aligned with the axis (A).Type: ApplicationFiled: October 14, 2003Publication date: April 22, 2004Applicant: Keiper GmbH & Co. KGInventors: Uwe Assmann, Mario Klein, Eckhard Nock
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Patent number: 6722739Abstract: In the case of a fitting (5) for a vehicle seat, in particular for a motor vehicle seat, having a first fitting part (7) which defines an at least partially closed structural space (7′), a second fitting part (8) which can be pivoted relative to the first fitting part (7), two locking elements (12, 15) which are effective between the fitting part (7, 8), and a control element (24) which is assigned to the one fitting part (8) and is arranged within the structural space (7′), for controlling the interaction between the locking elements (12, 15), in a partially-assembled state of the fitting (5) the control element (24) can be placed from outside the fitting (5) into the structural space (7′) and can be attached to the fitting part (8) assigned to it.Type: GrantFiled: September 27, 2002Date of Patent: April 20, 2004Assignee: Keiper GmbH & Co. KG.Inventors: Mario Klein, Martin Kraus, Eckhard Nock
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Publication number: 20030062755Abstract: In the case of a fitting (5) for a vehicle seat, in particular for a motor vehicle seat, having a first fitting part (7) which defines an at least partially closed structural space (7′), a second fitting part (8) which can be pivoted relative to the first fitting part (7), two locking elements (12, 15) which are effective between the fitting part (7, 8), and a control element (24) which is assigned to the one fitting part (8) and is arranged within the structural space (7′), for controlling the interaction between the locking elements (12, 15), in a partially-assembled state of the fitting (5) the control element (24) can be placed from outside the fitting (5) into the structural space (7′) and can be attached to the fitting part (8) assigned to it.Type: ApplicationFiled: September 27, 2002Publication date: April 3, 2003Applicant: KEIPER GmbH & CoInventors: Mario Klein, Martin Kraus, Eckhard Nock
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Patent number: 6540232Abstract: In an articulated fitting (1) for a vehicle seat, in particular for a motor-vehicle rear-seat bench, having a lower fitting part (5) and an upper fitting part (8), which can rotate relative to the lower fitting part (5), for attaching the backrest of the vehicle seat, the backrest (4) being pivotable by means of the articulated fitting (1) between at least one upright seat position, which can be locked by means of the articulated fitting (1), and a flat table position and/or lying position, which can be secured by means of the articulated fitting (1), a control cam (24) is provided on one of the two fitting parts (8), said control cam interacting with a control element (23) of the upper fitting part (5) in order to control the locking and/or securing by the articulated fitting (1).Type: GrantFiled: December 11, 2001Date of Patent: April 1, 2003Assignee: Keiper GmbH & Co.Inventors: Richard Hänsel, Wolfgang Boltze, Eckhard Nock, Mario Klein
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Publication number: 20030042780Abstract: In an unlocking device (21) in a vehicle seat, in particular an automobile seat, which is adapted for unlocking an adjuster or seat mounting (5), the unlocking device (21) comprises an unlocking element (27) extending into the adjuster or seat mounting (5), with the unlocking element (27) being mounted on a pivotally supported entrainment member (25) arranged on the outside of the adjuster or seat mounting (5).Type: ApplicationFiled: September 4, 2002Publication date: March 6, 2003Applicant: KEIPER GmbH & CoInventors: Mario Klein, Eckhard Nock, Richard Hansel, Martin Kraus
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Publication number: 20020050733Abstract: In an articulated fitting (1) for a vehicle seat, in particular for a motor-vehicle rear-seat bench, having a lower fitting part (5) and an upper fitting part (8), which can rotate relative to the lower fitting part (5), for attaching the backrest of the vehicle seat, the backrest (4) being pivotable by means of the articulated fitting (1) between at least one upright seat position, which can be locked by means of the articulated fitting (1), and a flat table position and/or lying position, which can be secured by means of the articulated fitting (1), a control cam (24) is provided on one of the two fitting parts (8), said control cam interacting with a control element (23) of the upper fitting part (5) in order to control the locking and/or securing by the articulated fitting (1).Type: ApplicationFiled: December 11, 2001Publication date: May 2, 2002Inventors: Richard Hansel, Wolfgang Boltze, Eckhard Nock, Mario Klein
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Publication number: 20010028189Abstract: In a pivot mechanism for a vehicle seat, comprising at least two members adapted for rotation relative to each other about a seat back pivot axle and for engagement by a locking device, at least one flexible actuation element for disengaging the locking device, whose line of action intersects the seat back pivot axle, and at least one deflection means for the flexible actuation element, one end of the flexible actuation element is attached to a member of the mechanism.Type: ApplicationFiled: March 22, 2001Publication date: October 11, 2001Applicant: KEIPER GMBH & COInventor: Mario Klein