Patents by Inventor Mario Klein

Mario Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240109976
    Abstract: The present invention relates to combination therapies employing anti-CD20/anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists, in particular 4-1 BBL trimer containing antigen binding molecules, the use of these combination therapies for the treatment of cancer and methods of using the combination therapies.
    Type: Application
    Filed: June 13, 2023
    Publication date: April 4, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Marina Bacac, Claudia Ferrera Koller, Christian Klein, Mario Perro, Johannes Sam, Pablo Umaña, Wei Xu
  • Publication number: 20240092856
    Abstract: The present invention relates to the combination therapy of specific PD-1-targeted IL-2 variant immunoconjugates with specific antibodies which bind human FAP and 4-1BB and optionally with an anti-CEA/anti-CD3 bispecific antibody.
    Type: Application
    Filed: March 8, 2022
    Publication date: March 21, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Marina BACAC, Christina CLAUS, Laura CODARRI DEAK, Sara COLOMBETTI, Christian KLEIN, Valeria G. NICOLINI, Mario PERRO, Johannes SAM, Christine TRUMPFHELLER, Pablo UMAÑA
  • Patent number: 6893093
    Abstract: In the case of a locking device (11) for a vehicle seat, in particular for a motor vehicle seat, having a pivotably mounted locking element (15), a counterpart element (18) which interacts with the locking element (15), a pivotably mounted, spring-loaded clamping eccentric (21) which acts on the locking element (15) and keeps the latter in engagement with the counterpart element (18) in a normal situation, and an intercepting component (25) which is coupled to the clamping eccentric (21) and supports the locking element (15) in a crash situation, a stop (35) which is assigned to the locking element (15) is provided for interaction with the clamping eccentric (21) in a crash situation.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: May 17, 2005
    Assignee: KEIPER GmbH & Co. KG
    Inventors: Eckhard Nock, Richard Hänsel, Mario Klein, Martin Kraus
  • Patent number: 6840579
    Abstract: In an unlocking device (21) in a vehicle seat, in particular an automobile seat, which is adapted for unlocking an adjuster or seat mounting (5), the unlocking device (21) comprises an unlocking element (27) extending into the adjuster or seat mounting (5), with the unlocking element (27) being mounted on a pivotally supported entrainment member (25) arranged on the outside of the adjuster or seat mounting (5).
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: January 11, 2005
    Assignee: Keiper GmbH & Co.
    Inventors: Mario Klein, Eckhard Nock, Richard Hänsel, Martin Kraus
  • Publication number: 20040245816
    Abstract: In the case of a locking device (11) for a vehicle seat, in particular for a motor vehicle seat, having a pivotably mounted locking element (15), a counterpart element (18) which interacts with the locking element (15), a pivotably mounted, spring-loaded clamping eccentric (21) which acts on the locking element (15) and keeps the latter in engagement with the counterpart element (18) in a normal situation, and an intercepting component (25) which is coupled to the clamping eccentric (21) and supports the locking element (15) in a crash situation, a stop (35) which is assigned to the locking element (15) is provided for interaction with the clamping eccentric (21) in a crash situation.
    Type: Application
    Filed: July 14, 2004
    Publication date: December 9, 2004
    Applicant: KEIPER GmbH & Co. KG
    Inventors: Eckhard Nock, Richard Hansel, Mario Klein, Martin Kraus
  • Publication number: 20040075325
    Abstract: In a fitting for a vehicle seat, particularly a motor vehicle seat, having a first fitting part (7), a second fitting part (8) pivotable relative to the first fitting part around an axis (A) defined by a bearing shaft (10), also having a compensation spring (12) acting between the first fitting part (7) and the second fitting part (8) through pretension, the compensation spring (12) bears, on the one hand, against the first fitting part (7) and, on the other hand, against a bearing component (20) of the second fitting part aligned with the axis (A).
    Type: Application
    Filed: October 14, 2003
    Publication date: April 22, 2004
    Applicant: Keiper GmbH & Co. KG
    Inventors: Uwe Assmann, Mario Klein, Eckhard Nock
  • Patent number: 6722739
    Abstract: In the case of a fitting (5) for a vehicle seat, in particular for a motor vehicle seat, having a first fitting part (7) which defines an at least partially closed structural space (7′), a second fitting part (8) which can be pivoted relative to the first fitting part (7), two locking elements (12, 15) which are effective between the fitting part (7, 8), and a control element (24) which is assigned to the one fitting part (8) and is arranged within the structural space (7′), for controlling the interaction between the locking elements (12, 15), in a partially-assembled state of the fitting (5) the control element (24) can be placed from outside the fitting (5) into the structural space (7′) and can be attached to the fitting part (8) assigned to it.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: April 20, 2004
    Assignee: Keiper GmbH & Co. KG.
    Inventors: Mario Klein, Martin Kraus, Eckhard Nock
  • Publication number: 20030062755
    Abstract: In the case of a fitting (5) for a vehicle seat, in particular for a motor vehicle seat, having a first fitting part (7) which defines an at least partially closed structural space (7′), a second fitting part (8) which can be pivoted relative to the first fitting part (7), two locking elements (12, 15) which are effective between the fitting part (7, 8), and a control element (24) which is assigned to the one fitting part (8) and is arranged within the structural space (7′), for controlling the interaction between the locking elements (12, 15), in a partially-assembled state of the fitting (5) the control element (24) can be placed from outside the fitting (5) into the structural space (7′) and can be attached to the fitting part (8) assigned to it.
    Type: Application
    Filed: September 27, 2002
    Publication date: April 3, 2003
    Applicant: KEIPER GmbH & Co
    Inventors: Mario Klein, Martin Kraus, Eckhard Nock
  • Patent number: 6540232
    Abstract: In an articulated fitting (1) for a vehicle seat, in particular for a motor-vehicle rear-seat bench, having a lower fitting part (5) and an upper fitting part (8), which can rotate relative to the lower fitting part (5), for attaching the backrest of the vehicle seat, the backrest (4) being pivotable by means of the articulated fitting (1) between at least one upright seat position, which can be locked by means of the articulated fitting (1), and a flat table position and/or lying position, which can be secured by means of the articulated fitting (1), a control cam (24) is provided on one of the two fitting parts (8), said control cam interacting with a control element (23) of the upper fitting part (5) in order to control the locking and/or securing by the articulated fitting (1).
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: April 1, 2003
    Assignee: Keiper GmbH & Co.
    Inventors: Richard Hänsel, Wolfgang Boltze, Eckhard Nock, Mario Klein
  • Publication number: 20030042780
    Abstract: In an unlocking device (21) in a vehicle seat, in particular an automobile seat, which is adapted for unlocking an adjuster or seat mounting (5), the unlocking device (21) comprises an unlocking element (27) extending into the adjuster or seat mounting (5), with the unlocking element (27) being mounted on a pivotally supported entrainment member (25) arranged on the outside of the adjuster or seat mounting (5).
    Type: Application
    Filed: September 4, 2002
    Publication date: March 6, 2003
    Applicant: KEIPER GmbH & Co
    Inventors: Mario Klein, Eckhard Nock, Richard Hansel, Martin Kraus
  • Publication number: 20020050733
    Abstract: In an articulated fitting (1) for a vehicle seat, in particular for a motor-vehicle rear-seat bench, having a lower fitting part (5) and an upper fitting part (8), which can rotate relative to the lower fitting part (5), for attaching the backrest of the vehicle seat, the backrest (4) being pivotable by means of the articulated fitting (1) between at least one upright seat position, which can be locked by means of the articulated fitting (1), and a flat table position and/or lying position, which can be secured by means of the articulated fitting (1), a control cam (24) is provided on one of the two fitting parts (8), said control cam interacting with a control element (23) of the upper fitting part (5) in order to control the locking and/or securing by the articulated fitting (1).
    Type: Application
    Filed: December 11, 2001
    Publication date: May 2, 2002
    Inventors: Richard Hansel, Wolfgang Boltze, Eckhard Nock, Mario Klein
  • Publication number: 20010028189
    Abstract: In a pivot mechanism for a vehicle seat, comprising at least two members adapted for rotation relative to each other about a seat back pivot axle and for engagement by a locking device, at least one flexible actuation element for disengaging the locking device, whose line of action intersects the seat back pivot axle, and at least one deflection means for the flexible actuation element, one end of the flexible actuation element is attached to a member of the mechanism.
    Type: Application
    Filed: March 22, 2001
    Publication date: October 11, 2001
    Applicant: KEIPER GMBH & CO
    Inventor: Mario Klein