Patents by Inventor Mario Leone

Mario Leone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of sterile active pharmaceutical ingredients
    Patent number: 10953115
    Abstract: The invention refers to a process for preparing sterile active pharmaceutical ingredients (APIs) useful in the preparation of sterile product for ophthalmic use. The process comprises the gamma-ray sterilization treatment of the APIs powder in a protective atmosphere.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: March 23, 2021
    Assignee: Icrom S.R.L.
    Inventors: Mario Leone, Pierfrancesco Morosini
  • PRODUCTION OF STERILE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20150141412
    Abstract: The invention refers to a process for preparing sterile active pharmaceutical ingredients (APIs) useful in the preparation of sterile product for ophthalmic use. The process comprises the gamma-ray sterilization treatment of the APIs powder in a protective atmosphere.
    Type: Application
    Filed: May 9, 2012
    Publication date: May 21, 2015
    Applicant: ICROM SpA
    Inventors: Mario Leone, Pierfrancesco Morosini
  • Aminothiazole derivatives useful in the preparation of &bgr;-lactam antibiotics
    Patent number: 6255480
    Abstract: Aminothiazole derivatives having the carboxyl activated by means of thioesters, said derivatives being condensable with &bgr;-lactam nuclei to yield &bgr;-lactam antibiotics
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: July 3, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Maurizio Zenoni, Mario Leone, Maurizio Serra, Mauro Filippi
  • Bioavailable crystalline form of cefuroxime axetil
    Patent number: 5677443
    Abstract: A bioavailable crystalline form of cefuroxime axetil, obtained by treating known crystalline or amorphous cefuroxime axetil with water or with a water-miscible organic solvent or with a mixture thereof at a temperature of between +20.degree. C. and +100.degree. C., followed by cooling and separating the crystalline product by known methods.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: October 14, 1997
    Assignee: ACS Dobfar S.p.A.
    Inventors: Maurizio Zenoni, Mario Leone, Angelo Cattaneo, Leonardo Marsili
  • Process for the selective sulfoxide reduction of 3-hydroxy cephem and 3-methylene cepham compounds
    Patent number: 5663330
    Abstract: Process for selectively reducing cephalosporin sulfoxides of 3-hydroxy cephem and 3-methylene cepham compounds by treatment with a chlorinating agent in the presence of a solvent and a base, which are both inert to the chlorinating agent.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: September 2, 1997
    Assignee: ACS Dobfar S.p.A.
    Inventors: Maurizio Zenoni, Mario Leone, Giuseppe Alessandro Donadelli
  • Oxime derivatives of cephalosporanic structure
    Patent number: 5574153
    Abstract: The invention relates to oxime derivatives of cephalosporanic structure, possessing antibacterial activity.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: November 12, 1996
    Assignee: ACS Dobfar S.p.A.
    Inventors: Maurizio Zenoni, Mario Leone, Riccardo Colombo