Abstract: Disclosed is a method for dynamically constructing and updating a model of 3-dimensional topography of a stock-pile of granular material is provided. The method includes dumping the granular material to a maximum slope in a column in the stock-pile, wherein the maximum slope is determined by analyzing digital scans of the stock-pile; reducing the maximum slope to a smaller value of the maximum slope, dynamically increasing the maximum slope linearly until it reaches the original value of the maximum slope to obtain a uniformly expanding plateau; defining an adjustable shape comprising a first distance and a second distance, wherein the adjustable shape is flat till the first distance and the second distance beyond which the adjustable shape varies with the maximum slope; and reclaiming the granular material that flows downhill from a center depth to update the model of the 3D topography of the stock-pile.

Abstract: Disclosed is a method for optimizing a mineral recovery process from ore material using a flotation chamber. The method comprises implementing a machine learning model to determine operational parameters of the flotation chamber, for the mineral recovery process based on a geometry of the flotation chamber and properties of the ore material. The method further comprises simulating the mineral recovery process using ranges of the determined operational parameters to determine a factor representative of a relationship between a gas hold-up value and a bubble diameter value. The method further comprises calculating the gas hold-up value and the bubble diameter value based on determined the operational parameters and the determined factor.

Abstract: The invention refers to a process for preparing sterile active pharmaceutical ingredients (APIs) useful in the preparation of sterile product for ophthalmic use. The process comprises the gamma-ray sterilization treatment of the APIs powder in a protective atmosphere.

Abstract: The invention refers to a process for preparing sterile active pharmaceutical ingredients (APIs) useful in the preparation of sterile product for ophthalmic use. The process comprises the gamma-ray sterilization treatment of the APIs powder in a protective atmosphere.

Abstract: Aminothiazole derivatives having the carboxyl activated by means of thioesters, said derivatives being condensable with &bgr;-lactam nuclei to yield &bgr;-lactam antibiotics

Abstract: A bioavailable crystalline form of cefuroxime axetil, obtained by treating known crystalline or amorphous cefuroxime axetil with water or with a water-miscible organic solvent or with a mixture thereof at a temperature of between +20.degree. C. and +100.degree. C., followed by cooling and separating the crystalline product by known methods.

Abstract: Process for selectively reducing cephalosporin sulfoxides of 3-hydroxy cephem and 3-methylene cepham compounds by treatment with a chlorinating agent in the presence of a solvent and a base, which are both inert to the chlorinating agent.

Abstract: The invention relates to oxime derivatives of cephalosporanic structure, possessing antibacterial activity.