Patents by Inventor MARIO PABLO ESTRADA GARCÍA
MARIO PABLO ESTRADA GARCÍA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11179455Abstract: The present invention is related to the use of the GHRP-6 and one structural analogue as molecular adjuvants for vaccines. Among other applications, these vaccines may be employed for preventing diseases caused by infectious agents, like viruses, bacteria and ectoparasites, that affect mammals, birds and aquatic organisms. The GHRP-6 and its analogue A233 are effectives as adjuvants when they are combine with a given antigen, since they enhance the specific immune response against it.Type: GrantFiled: October 30, 2017Date of Patent: November 23, 2021Assignee: CENTRO DE INGENIERIA GENÉTICA BIOTECNOLOGIAInventors: Rebeca Martínez Rodríguez, Liz Hernandez Perez, Lázaro Gil González, Yamila Carpio González, Mario Pablo Estrada García
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Publication number: 20200353065Abstract: The present invention is related to the use of the GHRP-6 and one structural analogue as molecular adjuvants for vaccines. Among other applications, these vaccines may be employed for preventing diseases caused by infectious agents, like viruses, bacteria and ectoparasites, that affect mammals, birds and aquatic organisms. The GHRP-6 and its analogue A233 are effectives as adjuvants when they are combine with a given antigen, since they enhance the specific immune response against it.Type: ApplicationFiled: October 30, 2017Publication date: November 12, 2020Inventors: REBECA MARTÍNEZ RODRÍGUEZ, LIZ HERNANDEZ PEREZ, LÁZARO GIL GONZÁLEZ, YAMILA CARPIO GONZÁLEZ, MARIO PABLO ESTRADA GARCÍA
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Patent number: 9603900Abstract: The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.Type: GrantFiled: August 28, 2015Date of Patent: March 28, 2017Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Mario Pablo Estrada Garcia, Juana Maria Lugo Gonzalez, Yamila Carpio Gonzalez, Carolina Tafalla Pineiro
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Patent number: 9549978Abstract: The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia (Oreochromis niloticus) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.Type: GrantFiled: October 1, 2012Date of Patent: January 24, 2017Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECHNOLOGIAInventors: Jannel Acosta Alba, Mario Pablo Estrada Garcia
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Patent number: 9549977Abstract: The present invention relates to the use of the pituitary adenylate cyclase activating peptide (PACAP) as a molecular adjuvant for vaccines. Among other applications, these vaccines may be used in the protection against infectious agents such as viruses, bacteria and ectoparasites affecting mammals, birds and aquatic organisms. The PACAP, combined with a particular antigen, demonstrates its effectiveness as adjuvant increasing the host immune response against that antigen. This type of response can be observed when the vaccine compositions or combinations that include PACAP are administered orally, by injection, or by immersion baths, in case of aquatic organisms.Type: GrantFiled: August 24, 2012Date of Patent: January 24, 2017Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECHNOLOGIAInventors: Juana Maria Lugo Gonzalez, Yamila Carpio Gonzalez, Mario Pablo Estrada Garcia
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Publication number: 20160030519Abstract: The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.Type: ApplicationFiled: August 28, 2015Publication date: February 4, 2016Inventors: Mario Pablo Estrada Garcia, Juana Maria Lugo Gonzalez, Yamila Carpio Gonzalez, Carolina Tafalla Pineiro
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Patent number: 9119830Abstract: The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.Type: GrantFiled: November 30, 2011Date of Patent: September 1, 2015Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Mario Pablo Estrada Garcia, Juna Maria Lugo Gonzalez, Yamila Carpio Gonzalez, Carolina Tafalla Piñeiro
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Patent number: 9085634Abstract: The present invention relates to the use of a peptide of P0 ribosomal protein in the manufacture of a vaccine composition to control of ectoparasite infestations and therefore the transmission of their associated pathogens. This peptide is located between 267 and 301 amino acids of the P0 protein, and can be obtained by recombinant means or by chemical synthesis. This peptide can be fused to a carrier protein or peptide, or an immuno-carrier and be included in an oily formulation. The formulations comprising the peptide vaccine confer protection against ticks and ectoparasites known as “sea lice” without generating autoimmunity in the host organism. Among these ticks may be mentioned species as Rhipicephalus microplus, Rhipicephalus sanguineus and Ixodes scapularis, and between sea lice are those of the Caligus and Lepeophtheirus genera.Type: GrantFiled: September 26, 2011Date of Patent: July 21, 2015Assignee: Centro de Ingeniería Genética y BiotecnologíaInventors: Alina Rodriguez Mallon, Erlinda Fernández Díaz, Mario Pablo Estrada Garcia, Yamila Carpio González
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Patent number: 9034339Abstract: The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a vaccine formulation as a purified protein and/or naked DNA, to induce an immune response in aquatic organisms against different ectoparasite species, including the known as sea lice, and pathogens associated with these infestations. The vaccine preparations, administered by oral route, immersion bath or injection, demonstrated its efficacy by producing IgM humoral immune response and reducing the number of parasites per fish in the vaccinated fishes.Type: GrantFiled: April 9, 2013Date of Patent: May 19, 2015Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Yamila Carpio Gonzalez, Mario Pablo Estrada Garcia
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Patent number: 9034338Abstract: The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a vaccine formulation as a purified protein and/or naked DNA, to induce an immune response in aquatic organisms against different ectoparasite species, including the known as sea lice, and pathogens associated with these infestations. The vaccine preparations, administered by oral route, immersion bath or injection, demonstrated its efficacy by producing IgM humoral immune response and reducing the number of parasites per fish in the vaccinated fishes.Type: GrantFiled: May 30, 2008Date of Patent: May 19, 2015Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Yamila Carpio Gonzalez, Mario Pablo Estrada Garcia
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Patent number: 8852601Abstract: The invention is related with the chemical synthesis for increase the growth rate in marketable fish and crustacean The aim of this invention is supply GHRP-6 to induce directly or indirectly the release of growthing hormone or like, to produce the increase of circulating growthing hormone level in the blood of the fishes. The peptide is stable, soluble and biologically active. The peptide is able to stimulate growth, improve the larvae quality, and increase the defense against pathogen agents, the dry weight, the protein concentration and the RNA in muscle of fish and crustaceans.Type: GrantFiled: January 22, 2003Date of Patent: October 7, 2014Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Mario Pablo Estrada Garcia, Rebeca Martinez Rodriguez, Amilcar Arenal Cruz, Rafael Marcos Pimentel Pérez, Antonio Morales Rojas, Eulogio Pimentel Vázquez, Alexander Espinosa Vázquez, Carmen Aday Garcia Molina, Edenaida Cabrera González, Mirta Vinjoy Campa, Sergio Toledo Pérez, Olimpia Carrillo Famés, Claudina Zaldivar Muñoz
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Publication number: 20140294871Abstract: The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia (Oreochromis niloticus) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions to for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.Type: ApplicationFiled: October 1, 2012Publication date: October 2, 2014Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Jannel Acosta Alba, Mario Pablo Estrada Garcia
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Publication number: 20140294889Abstract: The present invention relates to the use of the pituitary adenylate cyclase activating peptide (PACAP) as a molecular adjuvant for vaccines. Among other applications, these vaccines may be used in the protection against infectious agents such as viruses, bacteria and ectoparasites affecting mammals, birds and aquatic organisms. The PACAP, combined with a particular antigen, demonstrates its effectiveness as adjuvant increasing the host immune response against that antigen. This type of response can be observed when the vaccine compositions or combinations that include PACAP are administered orally, by injection, or by immersion baths, in case of aquatic organisms.Type: ApplicationFiled: August 24, 2012Publication date: October 2, 2014Applicant: Centro De Ingenieria Genetica y BiotecnologiaInventors: Juana Maria Lugo Gonzalez, Yamila Carpio Gonzalez, Mario Pablo Estrada Garcia
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Patent number: 8833306Abstract: The present invention is related to the use of variants of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) to stimulate the growth and to improve the immunological system of aquatic organisms. The variants of the peptide were provided by immersion, injection or as a food additive.Type: GrantFiled: November 20, 2006Date of Patent: September 16, 2014Assignee: Centro de Ingenieria Genetica Y BiotecnologiaInventors: Juana Maria Lugo González, Mario Pablo Estrada Garcia, Alina Rodriguez Mallon, Yamila Carpio González, Antonio Morales Rojas, Osmany Rodrigo González De Sosa, Reynold Morales Fernández, Fidel Francisco Herrera Miyares
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Publication number: 20140087998Abstract: The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.Type: ApplicationFiled: November 30, 2011Publication date: March 27, 2014Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Mario Pablo Estrada Garcia, Juana Maria Lugo Gonzalez, Yamila Carpio Gonzalez, Carolina Tafalla Piñeiro
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Publication number: 20130280290Abstract: The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a vaccine formulation as a purified protein and/or naked DNA, to induce an immune response in aquatic organisms against different ectoparasite species, including the known as sea lice, and pathogens associated with these infestations. The vaccine preparations, administered by oral route, immersion bath or injection, demonstrated its efficacy by producing IgM humoral immune response and reducing the number of parasites per fish in the vaccinated fishes.Type: ApplicationFiled: April 9, 2013Publication date: October 24, 2013Inventors: Yamila Carpio Gonzalez, Mario Pablo Estrada Garcia
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Publication number: 20130273095Abstract: The present invention relates to the use of a peptide of P0 ribosomal protein in the manufacture of a vaccine composition to control of ectoparasite infestations and therefore the transmission of their associated pathogens. This peptide is located between 267 and 301 amino acids of the P0 protein, and can be obtained by recombinant means or by chemical synthesis. This peptide can be fused to a carrier protein or peptide, or an immuno-carrier and be included in an oily formulation. The formulations comprising the peptide vaccine confer protection against ticks and ectoparasites known as “sea lice” without generating autoimmunity in the host organism. Among these ticks may be mentioned species as Rhipicephalus microplus, Rhipicephalus sanguineus and Ixodes scapularis, and between sea lice are those of the Caligus and Lepeophtheirus genera.Type: ApplicationFiled: September 26, 2011Publication date: October 17, 2013Applicant: CENTRO DE INGENIERIA GENETICA BIOTECNOLOGIAInventors: Alina Rodriguez Mallon, Erlinda Fernández Díaz, Mario Pablo Estrada Garcia, Yamila Carpio González
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Patent number: 8367620Abstract: Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.Type: GrantFiled: February 28, 2007Date of Patent: February 5, 2013Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Rolando Eduardo Rodriguez Fernandez, Ania De La Nuez Veulens, Mario Pablo Estrada Garcia, Rebeca Martinez Rodriguez, Glay Chinea Santiago, Osvaldo Reyes Acosta, Julio Raul Fernandez Masso, Diana Garcia del Barco Herrera, Jorge Amador Berlanga Acosta, Alexis Musacchio Lasa
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Patent number: 7919463Abstract: The present invention is related to polypeptides derived from tilapia growth hormone.Type: GrantFiled: June 23, 2006Date of Patent: April 5, 2011Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Jannel Acosta Alba, Mario Pablo Estrada Garcia, Yamila Carpio Gonzalez, Reynold Morales Fernandez
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Publication number: 20100221271Abstract: The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a vaccine formulation as a purified protein and/or naked DNA, to induce an immune response in aquatic organisms against different ectoparasite species, including the known as sea lice, and pathogens associated with these infestations. The vaccine preparations, administered by oral route, immersion bath or injection, demonstrated its efficacy by producing IgM humoral immune response and reducing the number of parasites per fish in the vaccinated fishes.Type: ApplicationFiled: May 30, 2008Publication date: September 2, 2010Inventors: Yamila Carpio Gonzalez, Mario Pablo Estrada Garcia