Abstract: The present disclosure related to a method of detecting a molecule using an antibody-DNA conjugate, and pharmaceutical compositions comprising new polypeptides and use thereof.

Abstract: Embodiments of a method and/or system can include administering, to a patient with one or more conditions associated with at least one of TMA, TMAO, and/or derivatives thereof, a therapeutically effective amount of a compound for affecting inhibiting one or more CutC enzymes and/or CntA enzymes associated with microorganisms from at least one taxon from a set of microorganism taxa.

Abstract: The present disclosure relates to pharmaceutical compounds and compositions and methods for treating an allergy and Crohn's disease. Methods for treating an allergy can include (a) predicting potential epitopes based proteomes of microbiome and that of an allergen, (b) filtering the potential epitopes obtained in step a) to result in a list of epitopes; and (c) reengineering the list of epitopes obtained in step b) to result in the new epitope. Methods for treating Crohn's disease can include (a), identifying one or more binding regions of an HLA class II protein and/or hemagglutinin to I2 superantigen; (b) determining a first peptide sequence corresponding to the one or more binding regions, and (c) producing a peptide inhibitor having a second peptide sequence that is a mutation of the first peptide sequence, wherein the second peptide sequence has a stronger binding affinity to the I2 superantigen than the first peptide sequence.

Abstract: The pesticide and method of manufacturing includes one component extracted from an evergreen Bush “Larrea tridentate” the common name of which is Gobernadora, in which the main active ingredient is nordihydroguaiaretic acid(NDGA) 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane, 4,4?-(2,3-Dimethyltetramethylene) dipyrocatechol. The composition of which is enriched with plant oils, emulsifiers and humidifiers, thus obtaining a product which can be easily used in crops with the help of sprinklers. Consequently, the action field of this procedure is within chemical compositions used to cultivate crops and fruit products.

Abstract: Embodiments of a method and/or system can include administering, to a patient with one or more conditions associated with at least one of TMA, TMAO, and/or derivatives thereof, a therapeutically effective amount of a compound for affecting inhibiting one or more CutC enzymes and/or CntA enzymes associated with microorganisms from at least one taxon from a set of microorganism taxa.

Abstract: Embodiments of a method and/or system (e.g, for metabolism-related prediction) can include: generating an enzyme dataset; generating a substrate dataset; generating a metabolism model such as for predicting an enzyme feature associated with metabolism of a query molecule, based on the enzyme dataset and/or the substrate dataset; determining a microorganism taxon (and/or microorganism taxa) S140 associated with the metabolism of the query molecule based on one or more predicted enzyme features of the metabolism model (e.g., machine learning model; etc.) and/or determining a query molecule score (e.g., drug score) for one or more users based on the microorganism taxon.

Abstract: The pesticide and method of manufacturing includes one component extracted from an evergreen Bush “Larrea tridentate” the common name of which is Gobernadora, in which the main active ingredient is nordihydroguaiaretic acid(NDGA) 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane, 4,4?-(2,3-Dimethyltetramethylene) dipyrocatechol. The composition of which is enriched with plant oils, emulsifiers and humidifiers, thus obtaining a product which can be easily used in crops with the help of sprinklers. Consequently, the action field of this procedure is within chemical compositions used to cultivate crops and fruit products.

Abstract: Embodiments of a method and/or system can include administering, to a patient with one or more conditions associated with at least one of TMA, TMAO, and/or derivatives thereof, a therapeutically effective amount of a compound for affecting inhibiting one or more CutC enzymes and/or CntA enzymes associated with microorganisms from at least one taxon from a set of microorganism taxa.

Abstract: The pesticide and method of manufacturing includes one component extracted from an evergreen Bush “Larrea tridentata” the common name of which is Gobernadora, in which the main active ingredient is nordihydroguaiaretic acid(NDGA) 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane, 4,4?-(2,3-Dimethyltetramethylene) dipyrocatechol. The composition of which is enriched with plant oils, emulsifiers and humidifiers, thus obtaining a product which can be easily used in crops with the help of sprinklers. Consequently, the action field of this procedure is within chemical compositions used to cultivate crops and fruit products.

Abstract: The method for a pesticide having an insecticide, acaricide and nematicide action is obtained from plant extracts that have important synergic interactions in pesticide activity. The characteristics of the pesticide are efficient control of insects, mites and nematodes, low toxicity for mammals and low persistence in the environment. This pesticide is a composition based on plant extracts containing isoquinoline alkaloids and their derivatives (0.1-20%) and flavonoids and their glycosylated derivatives (0.001-10%). Therefore, the field of the invention is generally organic pesticides and in particular to obtaining an organic pesticide which contains, as an active ingredient, a mixture of isoquinoline alkaloids and flavonoids to be used to control agricultural pests.

Abstract: The method for a pesticide having an insecticide, acaricide and nematicide action is obtained from plant extracts that have important synergic interactions in pesticide activity. The characteristics of the pesticide are efficient control of insects, mites and nematodes, low toxicity for mammals and low persistence in the environment. This pesticide is a composition based on plant extracts containing isoquinoline alkaloids and their derivatives (0.1-20%) and flavonoids and their glycosylated derivatives (0.001-10%). Therefore, the field of the invention is generally organic pesticides and in particular to obtaining an organic pesticide which contains, as an active ingredient, a mixture of isoquinoline alkaloids and flavonoids to be used to control agricultural pests.

Abstract: The present invention relates to a pesticide having an insecticide, acaricide and nematicide action obtained from plant extracts that have important synergic interactions in their pesticide activity, the characteristics of which are efficient control of insects, mites and nematodes; low toxicity for mammals and low persistence in the environment. This pesticide is a composition based on plant extracts which is characterized because it is constituted by: Isoquinoline alkaloids and their derivatives (0.1-20%) and Flavonoids and their glycosylated derivatives (0.001-10%). Therefore, the scope of the invention is aligned in general with organic pesticides and in particular to obtaining an organic pesticide which contains as active ingredient a mixture of isoquinoline alkaloids and flavonoids to be used to control agricultural pest.

Abstract: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Abstract: This invention relates to methods for inhibiting kinase activity and/or inhibiting angiogenesis and/or treating a disease responsive to inhibition of kinase activity and/or treating a cell proliferative disease and/or treating an ophthalmic disease, condition or disorder treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions comprising administering novel compounds that inhibit protein tyrosine kinase activity.

Abstract: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions.

Abstract: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions.

Abstract: The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling.

Abstract: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Abstract: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Abstract: The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds of general formula (A) wherein A1 is sulfur, A3 is CH, A2 is CH, D is heterocycle, Z is oxygen, SO0-2 or NR, Ar is phenyl and G is not a ring, and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.