Patents by Inventor Mario Virtuani

Mario Virtuani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bile acids conjugates with metal ion chelates and the use thereof
    Patent number: 6803030
    Abstract: Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: October 12, 2004
    Assignee: Bracco Imaging S.p.A.
    Inventors: Christoph De Haen, Andrea Beltrami, Enrico Cappelletti, Luciano Lattuada, Mario Virtuani
  • Bile acids conjugates with metal ion chelates and the use thereof
    Publication number: 20030113265
    Abstract: Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.), which consist of at least two chelating agents conjugated via a multivalent linker group, to a bile acid.
    Type: Application
    Filed: August 27, 2002
    Publication date: June 19, 2003
    Inventors: Christoph De Haen, Andrea Beltrami, Enrico Cappelletti, Luciano Lattuada, Mario Virtuani
  • Chelating compounds, their complexes with paramagnetic metals
    Patent number: 6509324
    Abstract: Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: January 21, 2003
    Assignee: Bracco S.p.A.
    Inventors: Maurizio Franzini, Andrea Beltrami, Luisella Calabi, Alessandro Maiocchi, Mario Virtuani, Pier Lucio Anelli, Kondareddiar Ramalingam, Ramachandran S. Ranganathan
  • CHELATING COMPOUNDS, THEIR COMPLEXES WITH PARAMAGNETIC METALS
    Publication number: 20030013859
    Abstract: Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with said metal ions and the physiologically compatible salts thereof, as well as the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).
    Type: Application
    Filed: September 24, 2001
    Publication date: January 16, 2003
    Inventors: Maurizio Franzini, Andrea Beltrami, Luisella Calabi, Alessandro Maiocchi, Mario Virtuani, Pier Lucio Anelli, Kondareddiar Ramalingam, Ramachandran S. Ranganathan
  • Diagnostic imaging contrast agent with improved in serum relaxivity
    Patent number: 6458337
    Abstract: Compounds of the formula when chelated with metals exhibit improved serum relaxivity and are used in magnetic resonance imaging, particularly for imaging the blood pool.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: October 1, 2002
    Assignee: Dibra S.p.A
    Inventors: Pier Lucio Anelli, Marco Lolli, Franco Fedeli, Mario Virtuani, Marino Brocchetta, Pierfrancesco Morosini, Daniela Palano
  • Chelated complexes of paramagnetic metals with low toxicity
    Patent number: 6177562
    Abstract: Compounds of formulae (I) and (II) wherein the R, R1, R2, R3 and R4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: January 23, 2001
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Franco Fedeli, Alessandro Maiocchi, Maurizio Franzini, Mario Virtuani
  • Chelated complexes of paramagnetic metals with low toxicity
    Patent number: 6149890
    Abstract: Compounds of formulae (I) and (II) ##STR1## wherein the R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: November 21, 2000
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Franco Fedeli, Alessandro Maiocchi, Maurizio Franzini, Mario Virtuani
  • Benzyloxy derivatives of DTPA for MRI
    Patent number: 6099824
    Abstract: Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) ##STR1## wherein R is a --(CH.sub.2).sub.m --O--R.sub.2 group or hydrogen,R.sub.2 is a (C.sub.6 -C.sub.10) aryl, or an alkyl(C.sub.1 -C.sub.5)-aryl(C.sub.6 -C.sub.10) group, substituted or not by a group L corresponding to a OH group or a OR.sub.3 group, wherein R.sub.3 is a linear or branched (C.sub.1 -C.sub.5) alkyl group; or L is NH.sub.2, halogen, COOH or CONR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are independently hydrogen, or a linear or branched (C.sub.1 -C.sub.5) alkyl which can be substituted by 1-6 hydroxy groups and/or 1-6 alkoxy groups,R.sub.1 can have the same meanings as R, independently from it, except for hydrogen,Z is independently OH or OR.sub.6, or NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are as previously defined, and R.sub.6 is a (C.sub.1 -C.sub.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: August 8, 2000
    Assignee: Dibra S.p.A.
    Inventors: Pier Lucio Anelli, Andrea Beltrami, Fulvio Uggeri, Mario Virtuani
  • Paramagnetic chelates for nuclear magnetic resonance diagnosis
    Patent number: 5733528
    Abstract: New compounds endowed with a chelating property for paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI) are described. A method of obtaining images of organs and tissues of a human or animal body by means of nuclear magnetic resonance is also described.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: March 31, 1998
    Assignee: Dibra S.p.A.
    Inventors: Ernst Felder, Pier Lucio Anelli, Mario Virtuani, Andrea Beltrami, Marco Lolli
  • Intermediates for chelating agents with prefixed symmetry and process for their preparation
    Patent number: 5539105
    Abstract: The preparation of compounds of formula (I), wherein R and R.sup.1 have the meanings specified in claim 1, is disclosed compounds (I) are useful intermediates for the preparation of chelating agents.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: July 23, 1996
    Assignee: DIBRA S.p.A.
    Inventors: Fulvio Uggeri, Pier L. Anelli, Marcella Murru, Mario Virtuani
  • Intermediates for chelating agents with prefixed symmetry and process for their preparation
    Patent number: 5424423
    Abstract: The preparation of compounds of formula (I), wherein R and R.sub.1 have the meanings specified in claim 1, is disclosed compounds (I) are useful intermediates for the preparation of chelating agents.
    Type: Grant
    Filed: February 26, 1993
    Date of Patent: June 13, 1995
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Pier L. Anelli, Marcella Murru, Mario Virtuani
  • Chelated complexes of paramagnetic metals with low toxicity
    Patent number: RE38329
    Abstract: Compounds of formula (I) and (II) wherein the R, R1, R2, R3 and R4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: November 25, 2003
    Assignee: Bracco Imaging S.p.A.
    Inventors: Fulvio Uggeri, Franco Fedeli, Alessandro Maiocchi, Maurizio Franzini, Mario Virtuani