Abstract: Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

Abstract: A system for enhancing drug treatment of a patient is disclosed having a computer, a database in data communication with said computer, said database having a plurality of sensory prompts, software executing on said computer for querying the database for sensory prompts corresponding with treatment of the patient, a user device in data communication with said computer for presenting at least one retrieved sensory prompt, a sensor associated with said user device for collecting patient information in response to the sensory prompt, software executing on said computer for receiving the patient information, software executing on said computer for inducing an activity or thought process modification based the patient information, software executing on said computer for transmitting activity, sensory data and thought process modification to a medical provider.

Abstract: A system for managing treatment of a patient is provided with a computer, a database in data communication with said computer, said database having a plurality of prompts, a user device in data communication with said computer for presenting a first prompt received from said computer to the patient, a camera associated with said user device for taking an image of the patient's face in response to the prompt, software executing on said computer for receiving the image and determining an emotion associated with said image, software executing on said user device which may present the determined emotion to the patient, software executing on said computer which may receive a confirmation as to whether the determined emotion is correct, and software executing on said computer querying the database based on the confirmed emotion to retrieve at least one additional prompts to be displayed to the patient to refine their treatment.

Abstract: A method of mechanically securing a first object including a thermoplastic material in a solid state to a second object with a generally flat sheet portion, with a perforation of the sheet portion, and with the sheet portion having an edge along the perforation is provided, wherein the first object is positioned relative to the second object so that the edge is in contact with the thermoplastic material and wherein mechanical vibration energy is coupled into the assembly including the first and second objects until a flow portion of the thermoplastic material due to friction heat generated between the edge and the thermoplastic material becomes flowable and flows around the edge to at least partially embed the edge in the thermoplastic material. After the mechanical vibration stops, the thermoplastic material is caused to re-solidify, whereby the re-solidified thermoplastic material at least partially embedding the edge anchors the first object in the second object.

Abstract: A cutter unit for carrying a cutter for cutting a phonographic record includes a cutter carrier and a cutter head. The cutter head is carried by the cutter carrier and arranged to be displaced relative to the cutter carrier, in particular to rotate around a cutter pivot, the cutter unit being arranged in a cartridge enclosing and protecting the cutter unit.

Abstract: The present invention relates to a computer implemented method for allowing the immune system of a patient to better function, said method comprising: gaining patient input data from the patient by presenting at least one page through an interface to the patient together with selection possibilities, assessing a patient specific psychological and/or social and/or medical status including the communication type of the patient based on at least one selection of the patient to the page, assembling of a patient specific content and presenting it in a patient status sensitive, tailored way in a communication flow wherein the communication flow includes a set of pages and selection possibilities of the patient.

Abstract: A method of mechanically securing a first object including a thermoplastic material in a solid state to a second object with a generally flat sheet portion, with a perforation of the sheet portion, and with the sheet portion having an edge along the perforation is provided, wherein the first object is positioned relative to the second object so that the edge is in contact with the thermoplastic material and wherein mechanical vibration energy is coupled into the assembly including the first and second objects until a flow portion of the thermoplastic material due to friction heat generated between the edge and the thermoplastic material becomes flowable and flows around the edge to at least partially embed the edge in the thermoplastic material. After the mechanical vibration stops, the thermoplastic material is caused to re-solidify, whereby the re-solidified thermoplastic material at least partially embedding the edge anchors the first object in the second object.

Abstract: A method of mechanically securing a first object including a thermoplastic material in a solid state to a second object with a generally flat sheet portion, with a perforation of the sheet portion, and with the sheet portion having an edge along the perforation is provided, wherein the first object is positioned relative to the second object so that the edge is in contact with the thermoplastic material and wherein mechanical vibration energy is coupled into the assembly including the first and second objects until a flow portion of the thermoplastic material due to friction heat generated between the edge and the thermoplastic material becomes flowable and flows around the edge to at least partially embed the edge in the thermoplastic material. After the mechanical vibration stops, the thermoplastic material is caused to re-solidify, whereby the re-solidified thermoplastic material at least partially embedding the edge anchors the first object in the second object.

Abstract: An EEG headpiece includes an array of electrode pins, each electrode pin extending between a proximal end, formed by a proximal end face, and a distal end and including a conducting electrode and a thermoplastic material. The thermoplastic material is arranged at least around a periphery of the electrode pin or is pressable from a hollow space to the periphery. Each electrode pin is equipped for the transmission of energy, especially mechanical vibration energy, from the proximal end face to the thermoplastic material to liquefy at least portions of the thermoplastic material from a solid state to a flowable state, whereby the thermoplastic material is capable of flowing into structures of a tissue portion surrounding the periphery and of forming, after re-solidification of the thermoplastic material, an anchoring of the electrode pin in the tissue portion.

Abstract: A system for establishing an anchorage in an operation site of a human or animal patient with the aid of a material having thermoplastic properties and vibration energy. The system includes a transmitting piece connected or connectable to an energy source for generating vibration energy, and a housing with an opening. The transmitting piece is arranged moveably within the housing, the opening being adapted to the transmitting piece for a distal portion of the transmitting piece to be able to protrude from the opening. The system also includes a driver being activatable for exerting a compression force on the transmitting piece, and a thermoplastic element arranged to be compressible between the transmitting piece and a counter element by the compression force. Furthermore, the system is equipped for shock-free initial positioning and pre-pressing of the transmitting piece against the thermoplastic element.

Abstract: A system for establishing an anchorage in an operation site of a human or animal patient with the aid of a material having thermoplastic properties and vibration energy. The system includes a transmitting piece connected or connectable to an energy source for generating vibration energy, and a housing with an opening. The transmitting piece is arranged moveably within the housing, the opening being adapted to the transmitting piece for a distal portion of the transmitting piece to be able to protrude from the opening. The system also includes a driver being activatable for exerting a compression force on the transmitting piece, and a thermoplastic element arranged to be compressible between the transmitting piece and a counter element by the compression force. Furthermore, the system is equipped for shock-free initial positioning and pre-pressing of the transmitting piece against the thermoplastic element.

Abstract: A system for establishing an anchorage or augmentation in hard tissue with the aid of a material having thermoplastic properties, which is brought to the site of the anchorage or reinforcement in a solid state, is liquefied in situ, and, in a liquefied state, is displaced to contact the object. The system includes a housing with a proximal housing part and mounted therein, a transmitting piece possibly coupled to an energy source and a driver spring, a distal housing part releasably coupled to the proximal housing part, a permeable sleeve couplable to the distal housing part, and a thermoplastic element positionable in the permeable sleeve. The two housing parts, the transmitting piece, the driver spring and the permeable sleeve form a closed load frame in which the thermoplastic element is compressed between the transmitting piece and the permeable sleeve.

Abstract: A system for establishing an anchorage in an operation site of a human or animal patient with the aid of a material having thermoplastic properties and vibration energy. The system includes a transmitting piece connected or connectable to an energy source for generating vibration energy, and a housing with an opening. The transmitting piece is arranged moveably within the housing, the opening being adapted to the transmitting piece for a distal portion of the transmitting piece to be able to protrude from the opening. The system also includes a driver being activatable for exerting a compression force on the transmitting piece, and a thermoplastic element arranged to be compressible between the transmitting piece and a counter element by the compression force. Furthermore, the system is equipped for shock-free initial positioning and pre-pressing of the transmitting piece against the thermoplastic element.

Abstract: An adaptor for securing a second object includes an anchoring part and an adjustment part, wherein the anchoring part includes a distally facing anchoring surface and a proximally facing first control surface. The adjustment part has a distally facing second control surface positioned to abut against the first control surface. The anchoring part and the adjustment part define a common axis that is not perpendicular to the z direction, wherein the first control surface and possibly also the second control surface is/are helical with respect to the axis. Thereby a relative z position of the adjustment part with respect to the anchoring part is defined by the relative orientation of the adjustment part with respect to the common axis while the second control surface abuts against the first control surface.

Abstract: A system for establishing an anchorage in an operation site of a human or animal patient with the aid of a material having thermoplastic properties and vibration energy. The system includes a transmitting piece connected or connectable to an energy source for generating vibration energy, and a housing with an opening. The transmitting piece is arranged moveably within the housing, the opening being adapted to the transmitting piece for a distal portion of the transmitting piece to be able to protrude from the opening. The system also includes a driver being activatable for exerting a compression force on the transmitting piece, and a thermoplastic element arranged to be compressible between the transmitting piece and a counter element by the compression force. Furthermore, the system is equipped for shock-free initial positioning and pre-pressing of the transmitting piece against the thermoplastic element.

Abstract: A method of mechanically securing a first object including a thermoplastic material in a solid state to a second object with a generally flat sheet portion, with a perforation of the sheet portion, and with the sheet portion having an edge along the perforation is provided, wherein the first object is positioned relative to the second object so that the edge is in contact with the thermoplastic material and wherein mechanical vibration energy is coupled into the assembly including the first and second objects until a flow portion of the thermoplastic material due to friction heat generated between the edge and the thermoplastic material becomes flowable and flows around the edge to at least partially embed the edge in the thermoplastic material. After the mechanical vibration stops, the thermoplastic material is caused to re-solidify, whereby the re-solidified thermoplastic material at least partially embedding the edge anchors the first object in the second object.

Abstract: A method of mechanically securing a first object including a thermoplastic material in a solid state to a second object with a generally flat sheet portion, with a perforation of the sheet portion, and with the sheet portion having an edge along the perforation is provided, wherein the first object is positioned relative to the second object so that the edge is in contact with the thermoplastic material and wherein mechanical vibration energy is coupled into the assembly including the first and second objects until a flow portion of the thermoplastic material due to friction heat generated between the edge and the thermoplastic material becomes flowable and flows around the edge to at least partially embed the edge in the thermoplastic material. After the mechanical vibration stops, the thermoplastic material is caused to re-solidify, whereby the re-solidified thermoplastic material at least partially embedding the edge anchors the first object in the second object.

Abstract: An adaptor is secured to a first object. The adaptor includes an anchoring part and an adjustment part. The anchoring part includes a distally facing anchoring surface and a proximally facing first control surface. The adjustment part has a distally facing second control surface positioned to abut against the first control surface. The first control surface or the second control surface or both is/are helical. Thereby a relative z position of the adjustment part with respect to the anchoring part is defined by the relative orientation of the adjustment part with respect to the common axis while the second control surface abuts against the first control surface. This is used to adjust the z position of the adjustment part relative to the first object, in connection with the orientation of the adjustment part being defined and possibly fixed by the function of the adaptor/the adjustment part.

Abstract: A method of mechanically securing a first object including a thermoplastic material in a solid state to a second object with a generally flat sheet portion, with a perforation of the sheet portion, and with the sheet portion having an edge along the perforation is provided, wherein the first object is positioned relative to the second object so that the edge is in contact with the thermoplastic material and wherein mechanical vibration energy is coupled into the assembly including the first and second objects until a flow portion of the thermoplastic material due to friction heat generated between the edge and the thermoplastic material becomes flowable and flows around the edge to at least partially embed the edge in the thermoplastic material. After the mechanical vibration stops, the thermoplastic material is caused to re-solidify, whereby the re-solidified thermoplastic material at least partially embedding the edge anchors the first object in the second object.

Abstract: An adaptor for anchoring a second object with respect to a first object includes an anchoring part and an adjustment part. The anchoring part includes a distally facing anchoring surface and a proximally facing first control surface, and the adjustment part includes a distally facing second control surface positioned to abut against the first control surface. The anchoring part and the adjustment part define a common axis, and the first control surface or the second control surface or both is/are helical with respect to the axis, whereby a relative z position of the adjustment part with respect to the anchoring part is adjustable by rotating the adjustment part relative to the anchoring part around the axis while the second control surface abuts against the first control surface.