Patents by Inventor Marion Dorsch

Marion Dorsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Treating Luekemia
    Publication number: 20150209365
    Abstract: A combination of a BCR-ABL inhibitor and a hedgehog pathway inhibitor for the treatment of leukemia.
    Type: Application
    Filed: April 8, 2015
    Publication date: July 30, 2015
    Applicant: Novartis AG
    Inventors: Mhairi Copland, Marion Dorsch, David Irvine, Paul W. Manley, Stefan Peukert
  • METHODS AND COMPOSITIONS FOR TREATING SOLID TUMORS AND OTHER MALIGNANCIES
    Publication number: 20150025074
    Abstract: A combination of a kinase inhibitors of mTOR and downstream effector and a hedgehog pathway inhibitor for the treatment of cancer.
    Type: Application
    Filed: October 9, 2014
    Publication date: January 22, 2015
    Inventors: Silvia Buonamici, Marion Dorsch, Carlos Garcia-Echeverria
  • SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS
    Publication number: 20140200217
    Abstract: The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 17, 2014
    Inventors: Marion Dorsch, John E. Monahan, Michael Patrick Morrissey, Shifeng Pan, Juliet Williams
  • Smoothened antagonism for the treatment of hedgehog pathway-related disorders
    Patent number: 8778927
    Abstract: The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: July 15, 2014
    Assignee: Novartis AG
    Inventors: Marion Dorsch, John E. Monahan, Michael Patrick Morrissey, Shifeng Pan, Juliet Williams
  • METHODS AND COMPOSITIONS FOR TREATING LUEKEMIA
    Publication number: 20120329798
    Abstract: A combination of a BCR-ABL inhibitor and a hedgehog pathway inhibitor for the treatment of leukemia.
    Type: Application
    Filed: August 28, 2012
    Publication date: December 27, 2012
    Inventors: Mhairi Copland, Marion Dorsch, David Irvine, Paul W. Manley, Stefan Peukert
  • METHODS AND COMPOSITIONS FOR TREATING SOLID TUMORS AND OTHER MALIGNANCIES
    Publication number: 20120232087
    Abstract: A combination of a kinase inhibitors of mTOR and downstream effector and a hedgehog pathway inhibitor for the treatment of cancer.
    Type: Application
    Filed: November 17, 2010
    Publication date: September 13, 2012
    Inventors: Silvia Buonamici, Marion Dorsch, Carlos Garcia-Echeverria
  • SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS
    Publication number: 20110183962
    Abstract: The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.
    Type: Application
    Filed: September 28, 2009
    Publication date: July 28, 2011
    Applicant: Novartis AG
    Inventors: Marion Dorsch, John E. Monahan, Michael Patrick Morrissey, Shifeng Pan, Juliet Williams
  • Leukemia Treatment
    Publication number: 20110039850
    Abstract: A combination of a BCR-ABL inhibitor and a hedgehog pathway inhibitor for the treatment of leukemia.
    Type: Application
    Filed: August 12, 2009
    Publication date: February 17, 2011
    Inventors: Mhairi Copland, Marion Dorsch, David Irvine, Paul W. Manley, Stefan Peukert