Patents by Inventor Marion Frederick Hawthorne

Marion Frederick Hawthorne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BORON CLUSTER COMPOUNDS AND USES THEREOF
    Publication number: 20190135838
    Abstract: The present invention relates to novel boron cluster compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Application
    Filed: January 3, 2019
    Publication date: May 9, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Boron cluster compounds and uses thereof
    Patent number: 10202406
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: February 12, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Synthesis of amine boranes and polyhedral boranes
    Patent number: 10179795
    Abstract: The present invention relates in general to a method for the synthesis and purification of 1) the polyhedral borane decahydrodecaborate and dodecahydrododecaborate anions and their salts and 2) amines and amine boranes. The organoammonium halide is combined with alkali metal tetrahydroborate to form organoammonium tetrahydroborate, which upon pyrolysis provides organoammonium decahydrodecaborate and organoammonium dodecahydrododecaborate.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: January 15, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Alexander Valentinovich Safronov, Satish Subray Jalisatgi, Marion Frederick Hawthorne
  • Synthesis of borane compounds
    Patent number: 10059599
    Abstract: The present invention is directed to a process for the synthesis of alkali metal tetrahydroborates-10B and amine borane-10B precursors, such as sodium tetrahydroborate-10B and triethylamine borane-10B.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: August 28, 2018
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Alexander Valentinovich Safronov, Satish Subray Jalisatgi, Marion Frederick Hawthorne
  • Process and device for the production of polyhedral boranes
    Patent number: 9598352
    Abstract: The present invention provides methods and devices for producing polyhedral boron compounds. The process is generally an anhydrous, one-pot process that comprises a pyrolytic reaction of a tetraborohydride with a quaternary amine salt to form the polyhedral borane. In another aspect of the present invention, polyhedral boranes are produced, without isolation of the Lewis base-borane complex.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: March 21, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Mark Wayne Lee, Marion Frederick Hawthorne
  • SYNTHESIS OF AMINE BORANES AND POLYHEDRAL BORANES
    Publication number: 20170066785
    Abstract: The present invention relates in general to a method for the synthesis and purification of 1) the polyhedral borane decahydrodecaborate and dodecahydrododecaborate anions and their salts and 2) amines and amine boranes. The organoammonium halide is combined with alkali metal tetrahydroborate to form organoammonium tetrahydroborate, which upon pyrolysis provides organoammonium decahydrodecaborate and organoammonium dodecahydrododecaborate.
    Type: Application
    Filed: February 3, 2015
    Publication date: March 9, 2017
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Alexander Valentinovich SAFRONOV, Satish Subray JALISATGI, Marion Frederick HAWTHORNE
  • COMPOSITIONS AND METHODS FOR BORON NEUTRON CAPTURE THERAPY
    Publication number: 20170007700
    Abstract: Provided herein are compositions and methods for boron neutron capture therapy. In particular, the disclosure relates to therapy using liposomal Na3[1-(2?-B10H9)-2-NH3B10H8] and K[nido-7-CH3(CH2)15-7,8-C2B9H11] sources. A composition for boron neutron capture therapy, comprising a liposome having an aqueous core and an encapsulating bilayer, wherein the aqueous core comprises Na3[1-(2?-B10H9)-2-NH3B10H8] (TAC) and the encapsulating bilayer comprises K[nido-7-CH3(CH2)15-7,8-C2B9H11] (MAC) is also provided.
    Type: Application
    Filed: February 23, 2015
    Publication date: January 12, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Satish S. Jalisatgi, Marion Frederick Hawthorne
  • SYNTHESIS OF BORANE COMPOUNDS
    Publication number: 20160347621
    Abstract: The present invention is directed to a process for the synthesis of alkali metal tetrahydroborates-10B and amine borane-10B precursors, such as sodium tetrahydroborate-10B and triethylamine borane-10B.
    Type: Application
    Filed: February 3, 2015
    Publication date: December 1, 2016
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: ALEXANDER VALENTINOVICH SAFRONOV, SATISH SUBRAY JALISATGI, MARION FREDERICK HAWTHORNE
  • CLUSTER BORON COMPOUNDS AND USES THEREOF
    Publication number: 20160031912
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Application
    Filed: August 18, 2015
    Publication date: February 4, 2016
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Cluster boron compounds and uses thereof
    Patent number: 9217002
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group. The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: December 22, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • CLUSTER BORON COMPOUNDS AND USES THEREOF
    Publication number: 20150072956
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group. The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.
    Type: Application
    Filed: September 13, 2012
    Publication date: March 12, 2015
    Applicant: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • PROCESS AND DEVICE FOR THE PRODUCTION OF POLYHEDRAL BORANES
    Publication number: 20140378707
    Abstract: The present invention provides methods and devices for producing polyhedral boron compounds. The process is generally an anhydrous, one-pot process that comprises a pyrolytic reaction of a tetraborohydride with a quaternary amine salt to form the polyhedral borane. In another aspect of the present invention, polyhedral boranes are produced, without isolation of the Lewis base-borane complex.
    Type: Application
    Filed: November 16, 2012
    Publication date: December 25, 2014
    Inventors: Mark Wayne Lee, Marion Frederick Hawthorne