Patents by Inventor Marion Goldeck

Marion Goldeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DISCONTINUOUS OLIGONUCLEOTIDE LIGANDS
    Publication number: 20230332148
    Abstract: The present invention relates to an oligonucleotide conjugate K of the structure RNA1-B-RNA2 RNA3 RNA4 or a pharmaceutically active salt thereof, wherein each RNA1, RNA2, RNA3 and RNA4 is a strand of a ribonucleic acid or of an analogue or of a derivative thereof, wherein B is a divalent linker that covalently bonds the 5? terminus of RNA1 to the 5? terminus of RNA2 or the 3? terminus of RNA1 to the 3? terminus of RNA2, and wherein RNA3 and RNA4 are not covalently bonded to each other. The invention further relates to the medical and non-medical use of such an oligonucleotide conjugate K and to corresponding manufacturing methods.
    Type: Application
    Filed: October 18, 2022
    Publication date: October 19, 2023
    Inventors: Marion Goldeck, Janos Ludwig
  • RIG-I ligands and methods for producing them
    Patent number: 11142763
    Abstract: The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and purification in high yield and purity suitable for pharmaceutical applications.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: October 12, 2021
    Assignee: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
    Inventors: Marion Goldeck, Jasper Van Den Boorn, János Ludwig, Christine Schuberth-Wagner
  • NOVEL RIG-I LIGANDS AND METHODS FOR PRODUCING THEM
    Publication number: 20180312841
    Abstract: The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and purification in high yield and purity suitable for pharmaceutical applications.
    Type: Application
    Filed: May 2, 2018
    Publication date: November 1, 2018
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
    Inventors: Marion GOLDECK, Jasper VAN DEN BOORN, János LUDWIG, Christine SCHUBERTH-WAGNER
  • RIG-I ligands and methods for producing them
    Patent number: 10072262
    Abstract: The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and purification in high yield and purity suitable for pharmaceutical applications.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: September 11, 2018
    Assignee: Rheinische Friedrich-Wilhelms-Universität Bonn
    Inventors: Marion Goldeck, Jasper Van Den Boorn, János Ludwig, Christine Schuberth-Wagner
  • RIG-I ligands and methods for producing them
    Patent number: 10059943
    Abstract: The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and purification in high yield and purity suitable for pharmaceutical applications.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: August 28, 2018
    Assignee: Rheinische Friedrich-Wilhelms-Universität Bonn
    Inventors: Marion Goldeck, Jasper Van Den Boorn, János Ludwig, Christine Schuberth-Wagner
  • DISCONTINUOUS OLIGONUCLEOTIDE LIGANDS
    Publication number: 20180195063
    Abstract: The present invention relates to an oligonucleotide conjugate K of the structure RNA1-B-RNA2 RNA3 RNA4 or a pharmaceutically active salt thereof, wherein each RNA1, RNA2, RNA3 and RNA4 is a strand of a ribonucleic acid or of an analogue or of a derivative thereof, wherein B is a divalent linker that covalently bonds the 5? terminus of RNA1 to the 5? terminus of RNA2 or the 3? terminus of RNA1 to the 3? terminus of RNA2, and wherein RNA3 and RNA4 are not covalently bonded to each other. The invention further relates to the medical and non-medical use of such an oligonucleotide conjugate K and to corresponding manufacturing methods.
    Type: Application
    Filed: July 4, 2016
    Publication date: July 12, 2018
    Inventors: Marion Goldeck, Janos Ludwig
  • Purification of triphosphorylated oligonucleotides using capture tags
    Patent number: 9896689
    Abstract: The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and purification of triphosphate-modified oligonucleotides in high yield and purity suitable for pharmaceutical applications.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 20, 2018
    Assignee: Rheinische Friedrich-Wilhelms-Universität Bonn
    Inventors: Janos Ludwig, Marion Goldeck, Brian Sproat
  • PURIFICATION OF TRIPHOSPHORYLATED OLIGONUCLEOTIDES USING CAPTURE TAGS
    Publication number: 20170145410
    Abstract: The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and purification of triphosphate-modified oligonucleotides in high yield and purity suitable for pharmaceutical applications.
    Type: Application
    Filed: June 10, 2016
    Publication date: May 25, 2017
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN
    Inventors: Janos LUDWIG, Marion GOLDECK, Brian SPROAT
  • PURIFICATION OF TRIPHOSPHORYLATED OLIGONUCLEOTIDES USING CAPTURE TAGS
    Publication number: 20160298116
    Abstract: The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and purification of triphosphate-modified oligonucleotides in high yield and purity suitable for pharmaceutical applications.
    Type: Application
    Filed: June 10, 2016
    Publication date: October 13, 2016
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN
    Inventors: Janos LUDWIG, Marion GOLDECK, Brian SPROAT
  • Purification of triphosphorylated oligonucleotides using capture tags
    Patent number: 9399658
    Abstract: The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and purification of triphosphate-modified oligonucleotides in high yield and purity suitable for pharmaceutical applications.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: July 26, 2016
    Assignee: Rheinische Friedrich-Wilhelms-Universität Bonn
    Inventors: Janos Ludwig, Marion Goldeck, Brian Sproat
  • NOVEL RIG-I LEGANDS AND METHODS FOR PRODUCING THEM
    Publication number: 20160152983
    Abstract: The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and purification in high yield and purity suitable for pharmaceutical applications.
    Type: Application
    Filed: September 26, 2013
    Publication date: June 2, 2016
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
    Inventors: Marion GOLDECK, Jasper VAN DEN BOORN, János LUDWIG, Christine SCHUBERTH-WAGNER
  • NOVEL RIG-I LIGANDS AND METHODS FOR PRODUCING THEM
    Publication number: 20150275217
    Abstract: The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and purification in high yield and purity suitable for pharmaceutical applications.
    Type: Application
    Filed: March 27, 2015
    Publication date: October 1, 2015
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
    Inventors: Marion GOLDECK, Jasper VAN DEN BOORN, János LUDWIG, Christine SCHUBERTH-WAGNER
  • PURIFICATION OF TRIPHOSPHORYLATED OLIGONUCLEOTIDES USING CAPTURE TAGS
    Publication number: 20140024819
    Abstract: The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and purification of triphosphate-modified oligonucleotides in high yield and purity suitable for pharmaceutical applications.
    Type: Application
    Filed: March 28, 2012
    Publication date: January 23, 2014
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN
    Inventors: Janos Ludwig, Marion Goldeck, Brian Sproat