Patents by Inventor Marion J. Bussemakers

Marion J. Bussemakers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid molecules comprising the promoter for PCA3, and uses thereof
    Patent number: 7138235
    Abstract: This invention describes the cloning and characterization of the promoter region for the PCA3dd3 gene. This region regulates the PCA3dd3 gene expression by a unique prostate specific transcriptional mechanism. The present invention relates to the use of this promoter region as a tool for prostate cancer treatment and diagnosis and screening of agents which regulate expression of PCA3. In a particular embodiment, the present invention relates to an isolated promoter sequence which comprises an isolated promoter sequence which comprises a sequence as set forth between nucleotide positions 372 to 460 of SEQ ID NO:1, this sequence enabling a prostate-specific modulation of transcription.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: November 21, 2006
    Assignee: Stichting Katholieke Universiteit
    Inventors: Marion J. Bussemakers, Gerald Verhaegh, Jack A. Schalken
  • Nucleic acid molecules comprising the promoter for PCA3, and uses thereof
    Patent number: 6897024
    Abstract: This invention describes the cloning and characterization of the promoter region for the PCA3dd3 gene. This region regulates the PCA3dd3 gene expression by a unique prostate specific transcriptional mechanism. The present invention relates to the use of this promoter region as a tool for prostate cancer treatment and diagnosis and screening of agents which regulate expression of PCA3. In a particular embodiment, the present invention relates to an isolated promoter sequence which comprises an isolated promoter sequence which comprises a sequence as set forth between nucleotide positions 372 to 460 of SEQ ID NO:1, this sequence enabling a prostate-specific modulation of transcription.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: May 24, 2005
    Assignee: Stichting Katholieke Universiteit more particularly The University Medical Centre Nijmegen
    Inventors: Marion J. Bussemakers, Gerald Verhaegh, Jack A. Schalken
  • Nucleic acid molecules comprising the promoter for PCA3dd3, a new prostate antigen, and uses thereof
    Publication number: 20030165850
    Abstract: This invention describes the cloning and characterization of the promoter region for the PCA3dd3 gene. This region regulates the PCA3dd3 gene expression by a unique prostate specific transcriptional mechanism. The present invention relates to the use of this promoter region as a tool for prostate cancer treatment and diagnosis and screening of agents which regulate expression of PCA3. In a particular embodiment, the present invention relates to an isolated promoter sequence which comprises an isolated promoter sequence which comprises a sequence as set forth between nucleotide positions 372 to 460 of SEQ ID NO:1, this sequence enabling a prostate-specific modulation of transcription.
    Type: Application
    Filed: November 30, 2001
    Publication date: September 4, 2003
    Applicant: UNIVERSITY HOSPITAL NIJMEGEN
    Inventors: Marion J. Bussemakers, Gerald Verhaegh, Jack A. Schalken