Patents by Inventor Marion Louise CRAWFORD

Marion Louise CRAWFORD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF TARGET MOLECULE CHARACTERISATION USING A MOLECULAR PORE
    Publication number: 20230374583
    Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled form the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.
    Type: Application
    Filed: April 12, 2023
    Publication date: November 23, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • SAMPLE PREPARATION METHOD
    Publication number: 20230250474
    Abstract: The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.
    Type: Application
    Filed: November 10, 2022
    Publication date: August 10, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • METHOD OF REPEATEDLY MOVING A DOUBLE-STRANDED POLYNUCLEOTIDE THROUGH A NANOPORE
    Publication number: 20230227902
    Abstract: Provided herein is a method of moving a double-stranded polynucleotide with respect to a nanopore using a motor protein. The method allows a portion of the polynucleotide to be interrogated by the pore multiple times. Also provided are polynucleotide adapters and kits comprising such adapters. The methods find use in characterising polynucleotides, for example in sequencing.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 20, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: James Edward Graham, Christopher Peter Youd, Clive Gavin Brown, Marion Louise Crawford, Andrew John Heron, James White
  • ENZYME STALLING METHOD
    Publication number: 20230212665
    Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.
    Type: Application
    Filed: December 14, 2022
    Publication date: July 6, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White
  • Method of target molecule characterisation using a molecular pore
    Patent number: 11649490
    Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled form the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: May 16, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • Enzyme stalling method
    Patent number: 11560589
    Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: January 24, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White
  • Sample preparation method
    Patent number: 11542551
    Abstract: The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: January 3, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid
    Patent number: 11236385
    Abstract: Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: February 1, 2022
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Marion Louise Crawford, James White
  • METHOD OF TARGET MOLECULE CHARACTERISATION USING A MOLECULAR PORE
    Publication number: 20210087621
    Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled form the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.
    Type: Application
    Filed: August 14, 2020
    Publication date: March 25, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • SAMPLE PREPARATION METHOD
    Publication number: 20200318179
    Abstract: The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.
    Type: Application
    Filed: April 22, 2020
    Publication date: October 8, 2020
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • Method of target molecule characterisation using a molecular pore
    Patent number: 10774378
    Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled from the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: September 15, 2020
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • Sample preparation method
    Patent number: 10669578
    Abstract: The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: June 2, 2020
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • METHOD FOR CHARACTERISING A DOUBLE STRANDED NUCLEIC ACID USING A NANO-PORE AND ANCHOR MOLECULES AT BOTH ENDS OF SAID NUCLEIC ACID
    Publication number: 20200102608
    Abstract: Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid.
    Type: Application
    Filed: May 21, 2019
    Publication date: April 2, 2020
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Marion Louise Crawford, James White
  • ENZYME STALLING METHOD
    Publication number: 20190211390
    Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.
    Type: Application
    Filed: January 9, 2019
    Publication date: July 11, 2019
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White
  • Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid
    Patent number: 10337060
    Abstract: The invention relates to a method for method of characterizing, such as sequencing, a target double stranded polynucleotide. The polynucleotide is coupled to a membrane using at least two adaptors with different strengths of coupling to the membrane.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 2, 2019
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Marion Louise Crawford, James White
  • Enzyme stalling method
    Patent number: 10221450
    Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterizing target polynucleotides using helicases.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: March 5, 2019
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White
  • METHOD OF TARGET MOLECULE CHARACTERISATION USING A MOLECULAR PORE
    Publication number: 20180087101
    Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled from the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.
    Type: Application
    Filed: March 31, 2015
    Publication date: March 29, 2018
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • METHOD FOR CHARACTERISING A DOUBLE STRANDED NUCLEIC ACID USING A NANO-PORE AND ANCHOR MOLECULES AT BOTH ENDS OF SAID NUCLEIC ACID
    Publication number: 20170204457
    Abstract: The invention relates to a method for method of characterising, such as sequencing, a target double stranded polynucleotide. The polynucleotide is coupled to a membrane using at least two adaptors with different strengths of coupling to the membrane.
    Type: Application
    Filed: March 31, 2015
    Publication date: July 20, 2017
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Marion Louise Crawford, James White
  • SAMPLE PREPARATION METHOD
    Publication number: 20170067101
    Abstract: The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.
    Type: Application
    Filed: February 19, 2015
    Publication date: March 9, 2017
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White
  • METHOD OF TARGET MOLECULE CHARACTERISATION USING A MOLECULAR PORE
    Publication number: 20170022557
    Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled from the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.
    Type: Application
    Filed: March 31, 2015
    Publication date: January 26, 2017
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: James Anthony Clarke, Marion Louise Crawford, James White