Patents by Inventor Marios Ioannides

Marios Ioannides has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR CLASSIFYING A SAMPLE INTO CLINICALLY RELEVANT CATEGORIES
    Publication number: 20240052424
    Abstract: The disclosure provides methods and kits for the classification of biological samples into clinically relevant categories.
    Type: Application
    Filed: December 16, 2021
    Publication date: February 15, 2024
    Inventors: George KOUMBARIS, Acilleas Achilleos, Alexia Eliades, Charalambos Loizides, Kyriakos Tsangaras, Marios Ioannides, Philippos Patsalis, Elena Xyori
  • Target-enriched multiplexed parallel analysis for assessment of risk for genetic conditions
    Patent number: 11879157
    Abstract: The invention provides methods for assessment of risk for genetic conditions using target-enriched multiplexed parallel analysis, for example fetal risk for genetic conditions in prenatal testing. The methods of the invention utilize Target Capture Sequences (TACS) to thereby enrich for target sequences of interest, followed by massive parallel sequencing and statistical analysis of the enriched population. The methods of the disclosure can be used to determine carrier status of inheritable genetic abnormalities associated with genetic conditions and from this information the fetal risk of inheriting the genetic condition can be determined. Kits for carrying out the methods of the invention are also provided.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: January 23, 2024
    Assignee: NIPD GENETICS PUBLIC COMPANY LIMITED
    Inventors: George Koumbaris, Marios Ioannides, Kyriakos Tsangaras, Charalambos Loizides, Michalis Nicolaou, Skevi Kyriakou, Philippos Patsalis, Elena Kypri
  • TARGET-ENRICHED MULTIPLEXED PARALLEL ANALYSIS FOR ASSESSMENT OF FETAL DNA SAMPLES
    Publication number: 20230416826
    Abstract: The invention provides methods for assessment of fetal DNA samples using target-enriched multiplexed parallel analysis. The methods of the invention utilize Target Capture Sequences (TACS) to thereby enrich for target sequences of interest, followed by massive parallel sequencing and statistical analysis of the enriched population. The methods can be used with fetal or embryonic DNA samples, for example for the detection of the presence of genetic abnormalities, e.g., for purposes of IVF Pre-implantation Genetic Screening (PGS) and Diagnosis (PGD). Kits for carrying out the methods of the invention are also provided.
    Type: Application
    Filed: May 11, 2023
    Publication date: December 28, 2023
    Inventors: George Koumbaris, Marios Ioannides, Elena Kypri, Acilleas Achilleos, Petros Mina, Kyriakos Tsangaras, Philippos Patsalis
  • Target-enriched multiplexed parallel analysis for assessment of fetal DNA samples
    Patent number: 11649500
    Abstract: The invention provides methods for assessment of fetal DNA samples using target-enriched multiplexed parallel analysis. The methods of the invention utilize Target Capture Sequences (TACS) to thereby enrich for target sequences of interest, followed by massive parallel sequencing and statistical analysis of the enriched population. The methods can be used with fetal or embryonic DNA samples, for example for the detection of the presence of genetic abnormalities, e.g., for purposes of IVF Pre-implantation Genetic Screening (PGS) and Diagnosis (PGD). Kits for carrying out the methods of the invention are also provided.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: May 16, 2023
    Assignee: NIPD GENETICS PUBLIC COMPANY LIMITED
    Inventors: George Koumbaris, Marios Ioannides, Elena Kypri, Acilleas Achilleos, Petros Mina, Kyriakos Tsangaras, Philippos Patsalis
  • TARGET-ENRICHED MULTIPLEXED PARALLEL ANALYSIS FOR ASSESSMENT OF TUMOR BIOMARKERS
    Publication number: 20220228219
    Abstract: The invention provides methods for assessment of tumor biomarkers using target-enriched multiplexed parallel analysis. The methods of the invention utilize Target Capture Sequences (TACS) to thereby enrich for target sequences of interest, followed by massive parallel sequencing and statistical analysis of the enriched population. The methods can be used with DNA samples from a patient, such as a tissue biopsy or plasma sample (liquid biopsy), for detection of the presence of tumor biomarkers, e.g., for purposes of diagnosis, screening, therapy selection and/or treatment monitoring. Kits for carrying out the methods of the invention are also provided.
    Type: Application
    Filed: July 6, 2018
    Publication date: July 21, 2022
    Inventors: George Koumbaris, Marios Ioannides, Elena Kypri, Acilleas Achilleos, Petros Mina, Alexia Eliades, Charalambos Loizides, Philippos Patsalis