Patents by Inventor Marisa E. Hom

Marisa E. Hom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoform-Specific Aldehyde Dehydrogenase Inhibitors
    Publication number: 20230174537
    Abstract: Compounds and methods are provided for inhibiting an aldehyde dehydrogenase (ALDH). Methods of treating cancer are also provided. The ALDH-inhibitor can be a compound that is based on a cyclic guanidine, or an imidazolium core. In certain embodiments, the ALDH-inhibitor compound is a substituted cyclic guanidine, or a substituted imidazolium compound. Aspects of the methods include methods of selectively inhibiting a particular ALDH family member. In some cases, the subject compounds are ALDH1 B1-selective inhibitors. In some cases, the subject compounds are ALDH1A3-selective inhibitors.
    Type: Application
    Filed: June 16, 2021
    Publication date: June 8, 2023
    Inventors: James Kenneth Chen, Zhiping Feng, Marisa E. Hom, Toni Kline, Cody R. Marshall, Alison E. Ondrus