Patents by Inventor Marit Laos

Marit Laos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    Publication number: 20220023280
    Abstract: This invention provides a composition comprising pridopidine or pharmaceutically acceptable salt thereof and at least one of compounds 1-8: or a pharmaceutically acceptable salt thereof; and to methods of use thereof.
    Type: Application
    Filed: October 11, 2021
    Publication date: January 27, 2022
    Inventors: Malle SCHMIDT, Malle PARI, Marit LAOS, Ants MAASALU, Kalle KALJUSTE
  • Analogs of pridopidine, their preparation and use
    Patent number: 11141412
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof, processes for making the same and to compositions comprising pridopidine with these compounds.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: October 12, 2021
    Assignee: PRILENIA NEUROTHERAPEUTICS LTD.
    Inventors: Malle Schmidt, Malle Pari, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    Publication number: 20200030308
    Abstract: This invention provides an isolated compound having the structure: or, or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 8, 2019
    Publication date: January 30, 2020
    Inventors: Malle SCHMIDT, Malle PARI, Marit LAOS, Ants MAASALU, Kalle KALJUSTE
  • Analogs of pridopidine, their preparation and use
    Patent number: 10406145
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: September 10, 2019
    Assignee: PRILENIA NEUROTHERAPEUTICS LTD.
    Inventors: Malle Schmidt, Malle Päri, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    Publication number: 20190030016
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 3, 2018
    Publication date: January 31, 2019
    Applicant: Teva Pharmaceutical Industries Ltd.
    Inventors: Malle Schmidt, Malle Päri, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • Analogs of pridopidine, their preparation and use
    Patent number: 10130621
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridne, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: November 20, 2018
    Assignee: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Malle Schmidt, Malle Päri, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    Publication number: 20150374677
    Abstract: This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridne, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 29, 2015
    Publication date: December 31, 2015
    Applicant: Teva Pharmaceutical Industries Ltd.
    Inventors: Malle Schmidt, Malle Päri, Marit Laos, Ants Maasalu, Kalle Kaljuste
  • Esters of (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid and their use for preparing (?)--homocitric acid gamma-lactone, (+)--homocitric acid gamma-lactone and the corresponding (?)--homocitric acid and (+)--homocitric acid salts
    Patent number: 8148568
    Abstract: Archiral (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid) alkyl, alkylphenyl and phenyl esters, and a simple and efficient method for the synthesis of both enantiomers of homocitric acid gamma-lactone and the corresponding salts from these esters are described. The method is based on asymmetric oxidation of esters, and the steps of basic and acidic hydrolysis and final acidic lactonization of the homocitric acid into homocitric acid gamma-lactone. The homocitric acid salts are obtained after basic treatment of homocitric acid gamma-lactone. The esters, conditions and reagents used in chemical conversion and separating products are important constituents affording efficient and simple method for production of homocitric acid gamma-lactone and homocitric acid salts.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: April 3, 2012
    Assignees: Tallinn University of Technology, Cambrex Tallinn AS
    Inventors: Margus Lopp, Anne Paju, Margus Eek, Marit Laos, Tonis Pehk, Raissa Jaalaid
  • ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS
    Publication number: 20090187041
    Abstract: Archiral (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid) alkyl, alkylphenyl and phenyl esters, and a simple and efficient method for the synthesis of both enantiomers of homocitric acid gamma-lactone and the corresponding salts from these esters are described. The method is based on asymmetric oxidation of esters, and the steps of basic and acidic hydrolysis and final acidic lactonization of the homocitric acid into homocitric acid gamma-lactone. The homocitric acid salts are obtained after basic treatment of homocitric acid gamma-lactone. The esters, conditions and reagents used in chemical conversion and separating products are important constituents affording efficient and simple method for production of homocitric acid gamma-lactone and homocitric acid salts.
    Type: Application
    Filed: May 25, 2007
    Publication date: July 23, 2009
    Applicants: Tallinn University of Technology, AS Vahiuuringute Tehnoloogia Arenduskeskus, Cambrex Tallinn AS
    Inventors: Margus Lopp, Anne Paju, Margus Eek, Marit Laos, Tõnis Pehk, Raissa Jäälaid