Abstract: Aptamers have been identified that bind to the sGP protein in ebola virus. The aptamers are single stranded DNA aptamers. The aptamers have high specificity and bind sGP in serum samples. The aptamers can be used to detect infection of individuals with ebola virus. Methods for detecting ebola virus in an individual are disclosed.

Abstract: Aptamers have been identified that bind to the sGP protein in ebola virus. The aptamers are single stranded DNA aptamers. The aptamers have high specificity and bind sGP in serum samples. The aptamers can be used to detect infection of individuals with ebola virus. Methods for detecting ebola virus in an individual are disclosed.

Abstract: The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.

Abstract: The present invention provides allosteric probes and methods of using allosteric probes for binding a first target and at least a second target. The probes have an allosteric molecule and at least one regulated aptamer. The binding of the allosteric molecule to a first target enhances or inhibits the binding of the at least one regulated aptamer to at least a second target. The binding of the at least one regulated aptamer to its target can be used to detect the presence of a particular target or targets or to selectively target a prodrug, drug, or toxin to a target cell or group of cells. The allosteric probes have a wide variety of diagnostic and therapeutic applications.

Abstract: The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.