Patents by Inventor Maritza Lienlaf Moreno

Maritza Lienlaf Moreno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR THE PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES (TILS) AND METHODS OF USING THE SAME
    Publication number: 20230220341
    Abstract: The present invention relates to methods for expanding TILs from tumor tissue using a long first expansion process and a shorter second expansion process. A method for expanding TIL includes obtaining a first population of TILs from a tumor resected from a subject, performing a first expansion for a period of about 21 day to about 35 days by culturing the first population of TILs in a cell culture medium comprising 4-1BB agonist, IL-2, and OKT-3 to produce a second population of TILs, and performing a second expansion for a period of about 7 days to about 10 days by supplementing the cell culture medium of the second population of TILs with antigen presenting cells (APCs) and additional 4-1BB agonist, IL-2, and OKT-3, and culturing to produce a third population of TILs, wherein the third population of TILs is a therapeutic population of TILs.
    Type: Application
    Filed: December 8, 2020
    Publication date: July 13, 2023
    Inventors: Cecile Chartier-Courtaud, Seth Wardell, Maritza Lienlaf Moreno
  • PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF THE SAME IN IMMUNOTHERAPY
    Publication number: 20230172987
    Abstract: The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
    Type: Application
    Filed: May 4, 2021
    Publication date: June 8, 2023
    Inventors: Seth WARDELL, Maritza Lienlaf MORENO
  • METHODS AND COMPOSITIONS FOR SELECTING TUMOR INFILTRATING LYMPHOCYTES AND USES OF THE SAME IN IMMUNOTHERAPY
    Publication number: 20220249559
    Abstract: The present invention provides improved methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for selecting TILs responsive to a mutant polypeptide expressed by cancer cells and not expressed in normal tissue.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 11, 2022
    Inventors: Seth Wardell, Maritza Lienlaf Moreno, Cecile Chartier-Courtaud, Lavakumar Karyampudi
  • PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USED OF THE SAME IN IMMUNOTHERAPY
    Publication number: 20220090018
    Abstract: The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
    Type: Application
    Filed: November 4, 2019
    Publication date: March 24, 2022
    Inventors: Seth Wardell, Maritza Lienlaf Moreno