Patents by Inventor Marius Brouwer

Marius Brouwer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Activated benzenepentacarboxylate-crosslinked low oxygen affinity hemoglobin
    Patent number: 5349054
    Abstract: The invention is directed to a stroma-free tetrameric mammalian hemoglobin which is crosslinked with benzenepentacarboxylate, in which the crosslinking is carried out by a method comprising the step of activating at least two carboxylate groups of the benzenepentacarboxylate with an activating agent prior to reaction with the hemoglobin as well as methods for its production. Crosslinked stroma-free hemoglobin produced by methods of the present invention may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or as in a plasma expander.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: September 20, 1994
    Assignee: Duke University
    Inventors: Joseph Bonaventura, Marius Brouwer, Robert E. Cashon
  • Benzenetricarboxylate derivative-crosslinked low oxygen affinity hemoglobin
    Patent number: 5334705
    Abstract: The invention is directed to a low oxygen affinity stroma-free tetrameric mammalian hemoglobin which is produced by crosslinkng with a derivative of benzenetricarboxylate, as well as methods for its preparation. Crosslinked stroma-free hemoglobin produced by methods of the present invention may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or as in a plasma expander.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: August 2, 1994
    Assignee: Duke University
    Inventors: Joseph Bonaventura, Marius Brouwer, Robert E. Cashon