Patents by Inventor Marjorie A. Mohler

Marjorie A. Mohler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and therapeutic compositions for the prevention of fibrin deposition or adhesions
    Patent number: 5589169
    Abstract: A method and pharmaceutical composition for the prevention of fibrin deposition or adhesion formation by topical application of a composition to a site of potential fibrin deposition or adhesion formation comprising a sparingly soluble enzyme that is continuously released at that site for a period of time of from about three days to two weeks which may include an inert adherence enhancing vehicle.
    Type: Grant
    Filed: April 13, 1990
    Date of Patent: December 31, 1996
    Assignee: Genentech, Inc.
    Inventors: Marjorie A. Mohler, Tue H. Nguyen
  • Method of diagnosing blood clots using fibrin-binding proteins
    Patent number: 5217705
    Abstract: A fibrin-binding protein such as t-PA is labeled with a detectable substance, such as a radionuclide, and administered to a patient for diagnosis of blood clots and for monitoring the dissolution thereof during therapy. The detectable substance preferably is attached to t-PA through linkers which specifically bind to the portion of the t-PA protein responsible for enzymatic activity, thereby diminishing this activity while leaving the fibrin-binding property of the protein intact.
    Type: Grant
    Filed: September 22, 1988
    Date of Patent: June 8, 1993
    Assignee: Neorx Corporation
    Inventors: John M. Reno, Stephen W. Hadley, Marjorie A. Mohler
  • Novel assay system for measuring human plasminogen actuator activity
    Patent number: 5096811
    Abstract: Disclosed is a means useful for selectively inhibiting human tissue plasminogen activator utilizing a thrombin inhibitor, illustrated by D-Phe-Pro-Arg-chloromethyl ketone (PPACK), thus providing a novel assay system for measuring human tissue plasminogen activator activity.
    Type: Grant
    Filed: November 7, 1989
    Date of Patent: March 17, 1992
    Assignee: Genentech, Inc.
    Inventors: Adair J. Hotchkiss, Marjorie A. Mohler