Patents by Inventor Marjorie Romkes

Marjorie Romkes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PARP genomic variants conferring resistance and sensitization to chemotherapy under inhibition
    Patent number: 10260108
    Abstract: A method is provided for selecting a subject diagnosed with cancer as a candidate for treatment with a PARP1 inhibitor, or both a PARP1 inhibitor and a chemotherapeutic agent such as an alkylating agent. The method includes detecting the presence or absence of a mutation in a non-coding region of a PARP1 gene, wherein the presence of a mutation in the PARP1 gene indicates that the cancer can be treated with the PARP1 inhibitor, optionally in conjunction with the chemotherapeutic agent. In a specific, non-limiting example, the PARP1 inhibitor is verliparib (ABT-888).
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: April 16, 2019
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Hussein A. Tawbi, Petr Pancoska, Panagiotis Benos, Marjorie Romkes, Andrew J. Sedgewick, Irina Abecassis
  • PARP GENOMIC VARIANTS CONFERRING RESISTANCE AND SENSITIZATION TO CHEMOTHERAPY UNDER INHIBITION
    Publication number: 20170342498
    Abstract: A method is provided for selecting a subject diagnosed with cancer as a candidate for treatment with a PARP1 inhibitor, or both a PARP1 inhibitor and a chemotherapeutic agent such as an alkylating agent. The method includes detecting the presence or absence of a mutation in a non-coding region of a PARP1 gene, wherein the presence of a mutation in the PARP1 gene indicates that the cancer can be treated with the PARP1 inhibitor, optionally in conjunction with the chemotherapeutic agent. In a specific, non-limiting example, the PARP1 inhibitor is verliparib (ABT-888).
    Type: Application
    Filed: October 30, 2015
    Publication date: November 30, 2017
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Hussein A. Tawbi, Petr Pancoska, Panagiotis Benos, Marjorie Romkes, Andrew J. Sedgewick, Irina Abecassis
  • Methods of assessment of drug metabolizing enzymes
    Publication number: 20040241714
    Abstract: The invention provides a method for assessing drug metabolizing enzyme expression levels in whole blood. The invention enables prediction of the effectiveness or safety of a drug therapy by providing a measure of the drug metabolizing capability of the patient. The invention provides a method for detecting and quantifying CYP2D6 mRNA in biological samples, a multiplex assay for detecting SNPs of CYP2D6 gene, and a multiplex assay for detecting SNPs of NAT1 and NAT2.
    Type: Application
    Filed: February 4, 2004
    Publication date: December 2, 2004
    Inventors: Robert A. Branch, Marjorie Romkes
  • Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450 2C subfamily
    Patent number: 5786191
    Abstract: The invention provides two novel members of the cytochrome P450 2C subfamily of enzymes, designated 2C18 and 2C19. DNA segments encoding these enzymes are also provided. The 2C19 polypeptide represents the principal human determinant of human S-mephenytoin 4'-hydroxylase activity. The invention also provides methods of identifying drugs metabolized by S-mephenytoin 4'-hydroxylase activity. Drugs shown to be metabolized by this activity should in general not be administered to individuals having, or belong to an ethnic group at risk of, a polymorphic deficiency in S-mephenytoin 4'-hydroxylase activity.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: July 28, 1998
    Inventors: Joyce A. Goldstein, Marjorie Romkes-Sparks