Abstract: Embodiments of the invention provide systems and methods for managing oncology care plans. The systems and methods involve or include: retrieving a standard care plan from an electronically stored library of oncology care plans provided by one or more clinical content providers; receiving, from a user, a modification to the standard care plan; generating a local care plan that includes the standard care plan and the modification to the standard care plan; retrieving, from the electronically stored library of oncology care plans, an updated standard care plan that includes one or more updates to the standard care plan provided by the one or more clinical content providers; and automatically generating an updated local care plan that includes the updated standard care plan and the modification to the standard care plan.