Abstract: The present invention relates to, inter alia, a novel crystalline free-plate habit or morphology, processes for preparing the crystalline free-plate habit, and uses of the crystalline free-plate habit of the L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid (Compound 1) in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in the vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).

Abstract: In an example in accordance with the present disclosure, an augmented reality (AR) display device is described. The AR display device includes a frame to be worn on a head of a user and a lens disposed within the frame. A user is to view a physical scene through the lens. The lens includes multiple regions. Each region is individually addressable and has a tint value that is individually adjustable. The AR display device also includes an input to receive virtual content to be presented on the lens and an imaging system to present the virtual content on the lens. The AR display device also includes a controller which 1) identifies a first region of the lens on which the virtual content is to be presented and 2) selectively adjusts a tint of the first region while suppressing a tint adjustment to a second region of the transparent lens.

Abstract: Disclosed herein are a method, a system, and a computer-readable storage-medium embodiments of automatic elastic CPU for a physical verification job. An embodiment includes generating multiple commands for a physical verification job of a design. The multiple commands are related by a dependency graph. The embodiment further includes allocating an initial amount of computing resources to execute the multiple commands, queuing a subset of the multiple commands for execution based on the dependency graph, adding an estimated amount of computing resources to the initial amount based on the number of the queued subset of commands and an estimated time to complete the queued subset of commands, and releasing a portion of the estimated amount of computing resources in response to the portion of the estimated amount of computing resources being idle for an amount of time greater than a target time.

Abstract: The subject matter of this specification can be embodied in, among other things, a fuel delivery component, a substantially rigid, unitary structure formed as a single piece of material, and at least a first seamless lumen defined by the unitary structure as a first loop.

Abstract: Systems and methods are described herein for implementing a hybrid codec to compress and decompress image data using both lossy and lossless compression. In one example encoding process, it may be determined whether a first block of pixels of a frame of image data contains an edge. A type of compression by which to encode the first block may be selected based on that determination. The first block may be compressed using the selected type of compression. At least one second value associated with the first block of pixels may be set to indicate at least oof the compressed value or the type of compression used to compress the first block.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A rotating linear adjustment bracket (RLAB) for use in providing connective support between construction building materials and a ground mounted pier includes a base plate mounted to a sleeve. The RLAB includes one or more gussets bridging the base to the sleeve to increase its strength. A bracket is then attached to the base plate for connecting various construction materials to the base plate. The bracket can be configured in various sizes and shapes as needed for attachment to the building construction materials.

Abstract: A steam dispersion system for building humidification is disclosed. At least a portion of the steam dispersion system is comprised of a flexible material that is collapsible for changing the outer dimension of the portion comprised of the flexible material from a greater, higher-pressure, size, to a smaller, lower-pressure, size.

Abstract: There is disclosed a composition comprising cannabidiol (CBD) and one or more cannabinoids selected from cannabidiolic acid (CBDA), cannabigerol (CBG) and cannabigerolic acid (CBGA) for use in the treatment or prevention of inflammation and disorders associated with inflammation or an IL-6 related disorder.

Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: An example operation includes starting, by a vehicle, a timer when a pairing request is initiated; receiving, by the vehicle, a first response to the pairing request from a first device and a second response to the pairing request from a second device; recording the timer when each of the first response and the second response are received; determining a first connection time, from the recorded timer, for the first device, and determining a second connection time, from the recorded timer, for the second device; and connecting, by the vehicle, to a device having a fastest connection time among the first device and the second device.

Abstract: A drilling system for use in drilling a wellbore including a driving mechanism and a separation device disposed upstream of the driving mechanism. The separation device filters at least a portion of any solids from drilling media flowing through a filter flow path of the separation device. The separation device flushes at least a portion of the filtered solids through a flush flow path, through a flush outlet on an outer surface of the separation device, and into an annulus between the outer surface of the separation device and the wellbore. Optionally, the drilling system includes a second driving mechanism and a second separation device disposed above the second driving mechanism.

Abstract: The present invention includes systems and methods for a continuous-wave (CW) radar system for detecting, geolocating, identifying, discriminating between, and mapping ferrous and non-ferrous metals in brackish and saltwater environments. The radar system (e.g., the CW radar system) generates multiple extremely low frequency (ELF) electromagnetic waves simultaneously and uses said waves to detect, locate, and classify objects of interest. These objects include all types of ferrous and non-ferrous metals, as well as changing material boundary layers (e.g., soil to water, sand to mud, rock to organic materials, water to air, etc.). The radar system (e.g., the CW radar system) is operable to detect objects of interest in near real time.

Abstract: An image sensing device including a Geiger-mode avalanche photodiode (GmAPD), a read out integrated circuit (ROIC), and a limit resistor connected to the GmAPD and the ROIC in series, wherein the ROIC includes an active quenching circuit.

Abstract: A dishwasher for treating dishes according to a cycle of operation, the dishwasher comprising a tub at least partially defining a treating chamber; a dish rack movably received within the treating chamber, configured for receiving dishes for treatment during the cycle of operation, and moveable relative to the tub; a sprayer located within the treating chamber, configured to emit spray into the dish rack; and a deflector having a base portion fixed to the sprayer, wherein the deflector includes at least one wall that extends away from the base portion such that the at least one wall is positioned to prevent contact between the dishes in the dish rack and the sprayer.

Abstract: We provide an ostomy collection device including: a housing defining a collecting volume for receiving and storing waste from an ostomy appliance, the housing including an inlet for fluidly connecting to an outlet of an ostomy appliance so that waste from the ostomy appliance flows into the collecting volume; and a cover layer positioned over an external surface of the housing.

Abstract: The subject matter of this specification can be embodied in, among other things, a fuel delivery component, including a substantially rigid, unitary structure formed as a single piece of material, and at least a first seamless lumen defined by the unitary structure.

Abstract: A 3D printer includes a nozzle configured to jet a drop of liquid metal therethrough. The 3D printer also includes a light source configured to illuminate the drop with a pulse of light. A duration of the pulse of light is from about 0.0001 seconds to about 0.1 seconds. The 3D printer also includes a camera configured to capture an image, video, or both of the drop. The 3D printer also includes a computing system configured to detect the drop in the image, the video, or both. The computing system is also configured to characterize the drop after the drop is detected. Characterizing the drop includes determining a size of the drop, a location of the drop, or both in the image, the video, or both.