Abstract: A pharmacotherapeutic protocol enhancing neuro-restoration in the human brain for patients suffering with brain injuries and diseases, wherein the protocol comprises treating the patient with a combinatorial pharmacological composition comprising a pharmacologically effective amount of a first Neuroplasticity PA therapeutic agent exhibiting a mechanism of plasticity in at least one of Neurogenesis, Synaptogenesis, Remyelination, Angiogenesis, Bioenergetics, Inflammation and Apoptosis, and a pharmacologically effective amount of a second Neuroplasticity PA therapeutic agent exhibiting a mechanism of plasticity in at least one of Neurogenesis, Synaptogenesis, Remyelination, Angiogenesis, Bioenergetics, Inflammation and Apoptosis; wherein the mechanism of plasticity of the first Neuroplasticity PA therapeutic agent differs from the mechanism of plasticity of the second Neuroplasticity PA therapeutic agent. Combinatorial pharmacological composition are also disclosed.

Abstract: This disclosure relates to a system that generates data describing physical surroundings of vehicles during operation. Individual vehicles carry sensors configured to generate output signals conveying information related to one or both of the physical surroundings of the vehicles and/or the operation of the vehicles. Based on the generated output signals, the physical surroundings in which the first vehicle is operating are derived, such as, for example, the speeds of different nearby vehicles, and their distances to each other.

Abstract: An ophthalmic system for measuring an eye comprises measuring devices and a computer. The measuring devices comprise an optical coherence tomography (OCT) device and an aberrometer. The OCT device directs OCT light towards the eye, and detects the OCT light reflected from the eye to measure the eye. The aberrometer directs aberrometer light towards the eye, and detects the aberrometer light reflected from the eye to measure the eye. The computer generates an ocular model of the eye according to the reflected OCT light. The ocular model comprises parameters for the eye, where each parameter is assigned a value. The computer determines an OCT-based wavefront according to the ocular model, determines an aberrometer-based wavefront according to the reflected aberrometer light, ascertains a deviation between the OCT-based wavefront and the aberrometer-based wavefront, and evaluates measurements from one or more of the measuring devices according to the deviation.

Abstract: According to the invention there is a method of applying a catalyst layer to a surface, the method comprising the steps of: providing a donor substrate having opposing first and second surfaces and providing a catalyst ink disposed as a layer on the second surface, wherein the catalyst ink comprises a catalyst and a solvent; providing an acceptor substrate, wherein the second surface of the donor substrate faces towards the acceptor substrate; and irradiating the catalyst ink with laser radiation at a wavelength which is absorbed by the catalyst ink so as to transfer the catalyst ink from the donor substrate to the acceptor substrate.

Abstract: An ophthalmic system for generating an ocular model of an eye includes an optical coherence tomography (OCT) device, an aberrometer, and a computer. The OCT device detects OCT light reflected from the eye. The aberrometer detects aberrometer light reflected from the eye. The computer generates the ocular model of the eye according to the reflected OCT light. The ocular model includes parameters describing the eye. The parameters include lens parameters that describe the lens of the eye. The computer determines an OCT-based wavefront according to the ocular model, determines an aberrometer-based wavefront according to the reflected aberrometer light, and compares the OCT-based and the aberrometer-based wavefronts. If the wavefronts differ beyond a predefined tolerance, the computer adjusts one or more values assigned to the parameters until the wavefronts satisfy the predefined tolerance. At least one adjusted value is assigned to a lens parameter.

Abstract: A method for detecting false positive variant calls in a next generation sequencing analysis pipeline involves obtaining a plurality of read pileup windows associated with a first sample genome. The method also involves obtaining, for each reference nucleotide position represented in the plurality of read pileup windows, a label indicating that the reference nucleotide position is either (i) a known variant or (ii) a non-variant. The method further involves training a neural network based on data indicative of the plurality of read pileup windows and the labels. Additionally, the method involves receiving a read pileup window associated with a second sample genome. Further, the method involves determining, using the trained neural network, a likelihood that the read pileup window associated with the second sample genome represents a variant.

Abstract: The electric vehicle that may comprise an electrical power system that includes a first DC link; a first swappable battery in electrical communication with the first DC link, and a second swappable battery substantially the same as the first swappable battery. The first swappable battery is configured to provide power to the electric vehicle during normal operation of the electric vehicle and to at least a first operation of the electric vehicle while the second swappable battery is removed from the electric vehicle and replaced. The second swappable battery is substantially the same as the first swappable battery and disposed on the electric vehicle, the second swappable battery configured to provide power to the electric vehicle during normal operation of the electric vehicle and to at least a second operation of the electrical vehicle while the first swappable battery is removed from the electric vehicle.

Abstract: A fiber optic installation device is disclosed for easily and efficiently installing fiber into an existing conduit in order to provide telecommunication and other services. The installation device includes a housing having first and second entry points. A first tube is releasably coupled to the first entry point, and configured for receiving a fiber cable, and a second tube is releasably coupled to the second entry point, and configured for receiving and securing an existing conduit so that the fiber optic cable can be pushed through and installed into the conduit. The cable is driven through the device via a drive wheel that is coupled to a drive shaft being driven by a standard electric drill. To prevent slippage of the cable, a pincher wheel is adjusted up or down via a knob to ensure the fiber optic cable remains in contact with the drive wheel throughout the installation process.

Abstract: A method is disclosed for manufacturing connectable or non-connectable elongate porous plastic profiles 12 from substantially continuous randomised extruded plastic strands made of recycled thermoplastics. Current manufacturing processes can manufacture similar products, comprising short partially melted plastic particles melded together forming planks. These planks, however, are inherently friable, easily broken and not readily connectable. These shortcomings are caused by the manufacturing method used, being friction plate agglomeration. This invention utilises an extrusion process, which produces substantially endless random strands of thermoplastic 13 which drop and are welded together to form a porous mass, which is then compressed into boards or planks by pulling the mass through a forming tool 6 and 7. The profile can be adjusted to form edge recesses allowing the planks to be fitted together, for instance to form area coverings, or they can simply be laid end to end to form drainage channels.

Abstract: Methods, systems, computer-readable media, devices, and apparatuses for synchronized mode transitions are presented. A first device configured to be worn at an ear includes a processor configured to, in a first contextual mode, receive a first mode change request from a second device to transition at a first time to a second contextual mode. The first mode change request is based on detection of a trigger condition. The processor is further configured to, at the first time, transition from the first contextual mode to the second contextual mode based on the first mode change request.

Abstract: A respiratory mask system is provided. The respiratory mask system has a patient interface that is secured to a user's head by a headgear. The patient interface comprises a seal, a frame and a gas delivery conduit. The frame is configured to secure the seal and gas delivery conduit together. The frame comprises a recessed channel and/or headgear retaining features configured to connect the headgear to the patient interface. The frame can include an inlet collar that connects to a gas delivery conduit. The inlet collar can include bias flow holes. The headgear comprises a top strap, a pair of side arms, a yoke and a rear strap. The yoke is configured to connect to the recessed channel of the frame. The top strap, side arms and yoke form an integrally formed closed loop. The top strap can include two portions adjustably connected to each other.

Abstract: A network station scheduling a frame to be transmitted by a transmitter of the network station at a transmit time. The transmit time is based on a first clock. A request is then issued to a direct memory access (DMA) circuit to retrieve the frame from a system memory. An advance time offset associated with the first clock is determined based on an estimated DMA latency of the DMA circuit. A frame retrieved by the DMA circuit is provided to a staging circuit. When a time of a second clock reaches the transmit time of the frame in the staging circuit, the frame is transmitted at the transmit time. In an example, a time of the first clock is ahead of a time of the second clock by the advance time offset.

Abstract: The parameters of an optical code are optimized to achieve improved signal robustness, reliability, capacity and/or visual quality. An optimization program can determine spatial density, dot distance, dot size and signal component priority to optimize robustness. An optical code generator employs these parameters to produce an optical code at the desired spatial density and robustness. The optical code is merged into a host image, such as imagery, text and graphics of a package or label, or it may be printed by itself, e.g., on an otherwise blank label or carton. A great number of other features and arrangements are also detailed.

Abstract: The present disclosure relates to bonding a first substrate together a second substrate with adhesives that are substantially tackifier free. A layer of substantially tackifier free adhesive may be applied to a first surface of the second substrate to define an adherence zone, and the first substrate is positioned on the adherence zone of the second substrate to form a laminate. The first and second substrates are pressed against each other in the adherence zone to force the substantially tackifier free adhesive to penetrate into the first and second substrates. A first portion of the layer of the adhesive penetrates into the first substrate and a second portion of the layer of the adhesive penetrates into the second substrate. A central portion of the layer of the adhesive between the first and second portions separates the second surface of the first substrate from the first surface of the second substrate.

Abstract: An embodiment of the present invention relates to a portable shelter, whether being of the type having a floating canopy or an umbrella. The shelter includes a support including an upright. A canopy is supported by the support. The canopy includes an expandable frame, and a sheet of material supported by the frame. The frame includes retractable ribs supporting the sheet. The frame also includes a stretcher arrangement for stretching out each rib from the support. The stretcher arrangement includes a first stretcher for coupling between the support and the rib; and a second stretcher for coupling to the first stretcher.

Abstract: Ophthalmic viewing systems for visualizing structures on and in an eye of a medical patient include an ophthalmic microscope, a gonioscopy device configured to work with the ophthalmic microscope to provide an image of an interior of the patient's eye, and a robotic arm configured to hold the gonioscopy device in a position in relation to the ophthalmic microscope and the patient's eye to provide the image of the eye's interior.

Abstract: A security fastener assembly is provided with a cap having a standard tool bearing surface and an attachment portion formed opposite the tool bearing surface. A fastener body has a mating attachment portion formed at a first end along which the cap is secured and a keyed security feature formed adjacent the mating attachment portion. A second end of the fastener body has a threaded fastener portion for securing the fastener assembly to a vehicle. The threaded portion of the fastener body is installed with rotation in a first direction. Engaging the tool bearing surface of the cap and rotating in a second direction opposite the first direction does not rotate the threaded portion of the fastener body. The fastener body is removable with the keyed security feature.

Abstract: Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease

Abstract: A method of detecting the presence of a person on a bed comprising, receiving movement data in pseudo-real-time, extracting features from the movement data for a time period in pseudo-real-time, recording the user's on-bed and off-bed time segments, and determining a sleep schedule. The method further comprising utilizing a sleep engine to determine sleep stages for the user, and calculating sleep conditions. The method in one embodiment further comprising adjusting the bed when the sleep conditions indicate an event.

Abstract: Disclosed is a method, performed by an electronic device, of obtaining location information of the electronic device, the method including obtaining at least one image captured by the electronic device, identifying a plurality of feature points included in the at least one image, obtaining a plurality of distances between the plurality of feature points and the electronic device, obtaining location information of the plurality of feature points, generating a plurality of circles having the obtained distances as radii and having the plurality of feature points as centers, based on the location information of the plurality of feature points, and obtaining location information of the electronic device based on a point where the plurality of circles overlap each other.