Abstract: A system and method for visualizing an eye using an optical coherence tomography (“OCT”) device includes a controller having a processor and a tangible, non-transitory memory on which instructions are recorded. The OCT device produces an OCT beam defined by an OCT beam axis. The controller is adapted to receive a first dataset captured with the OCT beam axis at a first tilt angle from a first visual axis. The controller is adapted to receive a second dataset captured with the OCT beam axis at a second tilt angle from a second visual axis. A plurality of lens segments is generated based on the first dataset and the second dataset. The controller is adapted to generate a lens profile based in part on the plurality of lens segments.

Abstract: The present invention relates to a collapsible infant carriage including a pair of shells for collapsing together. Advantageously, the infant carriage may be converted into a wheeled suitcase for straightforward and safe transport. Preferably, the carriage further includes a fastener for fastening the collapsed shells together so that the interior is protected from dirt and/or weather.

Abstract: Fall detection and reporting technology, in which output from at least one sensor configured to sense, in a room of a building, activity associated with a patient falling is monitored and a determination is made to capture one or more images of the room based on the monitoring. An image of the room is captured with a camera positioned to include the patient within a field of view of the camera and the captured image of the room is analyzed to detect a state of the patient at a time of capturing the image. A potential fall event for the patient is determined based on the detected state of the patient and a message indicating the potential fall event for the patient is sent based on the determination of the potential fall event for the patient. Techniques are also described for fall detection and reporting using an on-body sensing device.

Abstract: A work machine using a direct current power system that isolates reactive loads is described herein. The work machine uses a machine power distribution unit that receives direct current power from two or more battery banks of a power unit, whereby each of the battery banks deliver electrical power on a separate direct current bus. A machine power distribution unit of the work machine receives the electrical power from the battery and is used to isolate the power using bus connectors. One of the battery banks provides power to one direct current bus of the work machine and another battery bank provides power to another direct current bus of the work machine. A reactive load serviced by one of the battery banks is electrically disconnected from another reactive load serviced by the other battery bank.

Abstract: The present invention relates to a marina. The marina includes a spine. Vessel berths extend along the spine and are configured to enable vessels to berth obliquely to the spine. Advantageously, the vessels may be berthed obliquely to the spine, avoiding tight 90° turns, for safer berthing of the vessels. The berths may be reconfigured to accommodate vessels of different size, on a needs basis, for improved berthing efficiency.

Abstract: Variable data printing workflows are enhanced for use with content that includes 2D code patterns, such as digital watermark data. One arrangement includes applying a filter to a content stream within a PDF document to extract both first variable pattern data for a first watermark pattern and second variable pattern data for a second watermark pattern. A first composite watermark pattern is then defined based on the extracted first variable watermark pattern data in conjunction with static watermark pattern data, and a second composite watermark pattern is defined based on the extracted second variable watermark pattern data in conjunction with the static watermark pattern data. A variety of other features and arrangements are also detailed.

Abstract: Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease

Abstract: A monitoring device configured to be attached to a subject includes a photoplethysmography (PPG) sensor configured to measure physiological information from the subject, and at least one processor configured to process signals from the PPG sensor to determine heart rate and RR-interval (RRi) for the subject, and to determine a heart rate pattern for the subject over a period of time. The at least one processor is configured to change a sampling frequency of the PPG sensor for determining RRi in response to the determined heart rate pattern. The at least one processor is configured to reduce the sampling frequency of the PPG sensor in response to determining a pattern of heart rate below a threshold.

Abstract: A method and buoyancy system are disclosed for facilitating diver directed underwater friction welding (also known as friction welding) operations. Various illustrative embodiments of the method, buoyancy system and combined portable friction welding system and buoyancy provisions are disclosed for improving ease of diver use in making underwater joints.

Abstract: An ophthalmic system for measuring an eye comprises measuring devices and a computer. The measuring devices comprise an optical coherence tomography (OCT) device and an aberrometer. The OCT device directs OCT light towards the eye, and detects the OCT light reflected from the eye to measure the eye. The aberrometer directs aberrometer light towards the eye, and detects the aberrometer light reflected from the eye to measure the eye. The computer generates an ocular model of the eye according to the reflected OCT light. The ocular model comprises parameters for the eye, where each parameter is assigned a value. The computer determines an OCT-based wavefront according to the ocular model, determines an aberrometer-based wavefront according to the reflected aberrometer light, ascertains a deviation between the OCT-based wavefront and the aberrometer-based wavefront, and evaluates measurements from one or more of the measuring devices according to the deviation.

Abstract: A pharmacotherapeutic protocol enhancing neuro-restoration in the human brain for patients suffering with brain injuries and diseases, wherein the protocol comprises treating the patient with a combinatorial pharmacological composition comprising a pharmacologically effective amount of a first Neuroplasticity PA therapeutic agent exhibiting a mechanism of plasticity in at least one of Neurogenesis, Synaptogenesis, Remyelination, Angiogenesis, Bioenergetics, Inflammation and Apoptosis, and a pharmacologically effective amount of a second Neuroplasticity PA therapeutic agent exhibiting a mechanism of plasticity in at least one of Neurogenesis, Synaptogenesis, Remyelination, Angiogenesis, Bioenergetics, Inflammation and Apoptosis; wherein the mechanism of plasticity of the first Neuroplasticity PA therapeutic agent differs from the mechanism of plasticity of the second Neuroplasticity PA therapeutic agent. Combinatorial pharmacological composition are also disclosed.

Abstract: An ophthalmic system for generating an ocular model of an eye includes an optical coherence tomography (OCT) device, an aberrometer, and a computer. The OCT device detects OCT light reflected from the eye. The aberrometer detects aberrometer light reflected from the eye. The computer generates the ocular model of the eye according to the reflected OCT light. The ocular model includes parameters describing the eye. The parameters include lens parameters that describe the lens of the eye. The computer determines an OCT-based wavefront according to the ocular model, determines an aberrometer-based wavefront according to the reflected aberrometer light, and compares the OCT-based and the aberrometer-based wavefronts. If the wavefronts differ beyond a predefined tolerance, the computer adjusts one or more values assigned to the parameters until the wavefronts satisfy the predefined tolerance. At least one adjusted value is assigned to a lens parameter.

Abstract: A method for detecting false positive variant calls in a next generation sequencing analysis pipeline involves obtaining a plurality of read pileup windows associated with a first sample genome. The method also involves obtaining, for each reference nucleotide position represented in the plurality of read pileup windows, a label indicating that the reference nucleotide position is either (i) a known variant or (ii) a non-variant. The method further involves training a neural network based on data indicative of the plurality of read pileup windows and the labels. Additionally, the method involves receiving a read pileup window associated with a second sample genome. Further, the method involves determining, using the trained neural network, a likelihood that the read pileup window associated with the second sample genome represents a variant.

Abstract: The electric vehicle that may comprise an electrical power system that includes a first DC link; a first swappable battery in electrical communication with the first DC link, and a second swappable battery substantially the same as the first swappable battery. The first swappable battery is configured to provide power to the electric vehicle during normal operation of the electric vehicle and to at least a first operation of the electric vehicle while the second swappable battery is removed from the electric vehicle and replaced. The second swappable battery is substantially the same as the first swappable battery and disposed on the electric vehicle, the second swappable battery configured to provide power to the electric vehicle during normal operation of the electric vehicle and to at least a second operation of the electrical vehicle while the first swappable battery is removed from the electric vehicle.

Abstract: A method is disclosed for manufacturing connectable or non-connectable elongate porous plastic profiles 12 from substantially continuous randomised extruded plastic strands made of recycled thermoplastics. Current manufacturing processes can manufacture similar products, comprising short partially melted plastic particles melded together forming planks. These planks, however, are inherently friable, easily broken and not readily connectable. These shortcomings are caused by the manufacturing method used, being friction plate agglomeration. This invention utilises an extrusion process, which produces substantially endless random strands of thermoplastic 13 which drop and are welded together to form a porous mass, which is then compressed into boards or planks by pulling the mass through a forming tool 6 and 7. The profile can be adjusted to form edge recesses allowing the planks to be fitted together, for instance to form area coverings, or they can simply be laid end to end to form drainage channels.

Abstract: A respiratory mask system is provided. The respiratory mask system has a patient interface that is secured to a user's head by a headgear. The patient interface comprises a seal, a frame and a gas delivery conduit. The frame is configured to secure the seal and gas delivery conduit together. The frame comprises a recessed channel and/or headgear retaining features configured to connect the headgear to the patient interface. The frame can include an inlet collar that connects to a gas delivery conduit. The inlet collar can include bias flow holes. The headgear comprises a top strap, a pair of side arms, a yoke and a rear strap. The yoke is configured to connect to the recessed channel of the frame. The top strap, side arms and yoke form an integrally formed closed loop. The top strap can include two portions adjustably connected to each other.

Abstract: A network station scheduling a frame to be transmitted by a transmitter of the network station at a transmit time. The transmit time is based on a first clock. A request is then issued to a direct memory access (DMA) circuit to retrieve the frame from a system memory. An advance time offset associated with the first clock is determined based on an estimated DMA latency of the DMA circuit. A frame retrieved by the DMA circuit is provided to a staging circuit. When a time of a second clock reaches the transmit time of the frame in the staging circuit, the frame is transmitted at the transmit time. In an example, a time of the first clock is ahead of a time of the second clock by the advance time offset.