Patents by Inventor Mark A. Atkinson

Mark A. Atkinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarkers for differentiating between type 1 and type 2 diabetes
    Patent number: 7648825
    Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: January 19, 2010
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Tamir M. Ellis, Alba Esther Morales, Mark A. Atkinson, Clive H. Wasserfall
  • Materials and Methods for Reversing Type-1 Diabetes
    Publication number: 20090162345
    Abstract: In accordance with the subject invention, anti-thymocyte globulin (ATG) can be used to modulate a patient's immune response in order to prevent and/or delay the onset or the progression of type 1 diabetes. ATG treatment augments CD4+CD25+ cell frequencies and their functional activities.
    Type: Application
    Filed: November 29, 2006
    Publication date: June 25, 2009
    Inventors: Mark A. Atkinson, Gregory Simon, Clive Henry Wasserfall, Abraham Scaria, Desmond A. Schatz, Donna Armentano, Srinivas Shankara
  • RAAV VECTOR-BASED COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MAMMALIAN DISEASES
    Publication number: 20090111766
    Abstract: Disclosed are recombinant adeno-associated viral (rAAV) vector compositions that are expressed in selected mammalian cells, such as pancreatic islets cells, and that encode one or more mammalian serpin or cytokine polypeptides having therapeutic efficacy in the amelioration, treatment and/or prevention of interleukin deficiencies, such as for example diabetes, and related diseases of the pancreas. Also disclosed are methods and compositions for preventing diabetes in a mammal, reducing the rate of disease progression, and ameliorating the symptoms of diabetes in humans at risk for developing such conditions.
    Type: Application
    Filed: June 16, 2008
    Publication date: April 30, 2009
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.
    Inventors: Mark A. Atkinson, Terence R. Flotte, Sihong Song, Scott A. Loiler
  • Methods and compositions for expressing a nucleic acid in a dendritic cell
    Publication number: 20040072351
    Abstract: Recombinant adeno-associated virus (rAAV) virions having a serotype 1 capsid protein are effective for transferring heterologous nucleic acids into DC.
    Type: Application
    Filed: April 30, 2003
    Publication date: April 15, 2004
    Inventors: Karl L. Womer, Sihong Song, Terence R. Flotte, Scott A. Loiler, Mark A. Atkinson, Michael Clare-Salzler, Jude Samulski, Chengwin Li
  • Methods and compositions for early detection and treatment of insulin dependent diabetes mellitus
    Patent number: 6300089
    Abstract: The subject invention concerns a novel process for the early detection of insulin dependent diabetes (IDD). The novel process described here enables the detection of the onset of IDD before clinical symptoms appear. The novel process involves the detection, in a sample of biological fluid, of an autoantibody which is highly specific to individuals who will later develop the clinical manifestations of IDD. Novel treatments for the prevention of IDD are also described.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 9, 2001
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Mark A. Atkinson, Noel K. Maclaren
  • Method and compositions for early detection and treatment of insulin dependent diabetes mellitus
    Patent number: 6001360
    Abstract: Compositions and methods for the treatment or prevention of insulin dependent diabetes (IDD) are provided. Specifically, glutamic acid decarboxylase (GAD) proteins, and fragments. thereof, can be administered to an animal in order to the reduce the severity of IDD.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 14, 1999
    Assignee: University of Florida
    Inventors: Mark A. Atkinson, Noel K. Maclaren
  • Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
    Patent number: 5762937
    Abstract: The invention pertains to the discovery of antigenic cross reactivity between a pancreatic 64K autoantigen and glutamic acid decarboxylase (GAD). Autoantibodies toward GAD were found to be associated with insulin dependent diabetes (IDD). More specifically, the invention pertains to the use of GAD for the diagnosis, prevention and treatment of insulin dependent diabetes (IDD).
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: June 9, 1998
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Mark A. Atkinson, Noel K. Maclaren
  • Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
    Patent number: 5645998
    Abstract: The subject invention concerns a process for the early detection of insulin dependent diabetes (IDD). The process described here enables the detection of the onset of IDD before clinical symptoms appear. The process involves the detection, in a sample of biological fluid, of an autoantibody which is highly specific to individuals who will later develop the clinical manifestations of IDD. Novel treatments for the prevention of IDD are also described.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: July 8, 1997
    Assignee: University of Florida Research Foundation
    Inventors: Mark A. Atkinson, Noel K. Maclaren