Abstract: A tube fitting for a tube end has a female threaded member that cooperates with a male threaded member. The female member includes a tube gripping device in the form of a gripping ring or ferrule that is attached to the female member by a frangible web. Upon a partial pull-up the ferrule engages a camming surface on the male threaded member and breaks off or separates from the female threaded member to become a separate piece so that the fitting then functions as a single ferrule tube fitting. Additional features include a steep camming angle on the camming surface to cause the ferrule to grip the tube end with a bite-type action and to form a primary seal between the camming surface and a front end of the separated ferrule. The ferrule front end, and optionally the entire female threaded member including the initially integral tube gripping device, are hardened to be at least about 3.3 times harder than the material of the tube end.

Abstract: The electro-pneumatic latching valve system having an electrical switch unit that further includes an “apply” or “activate” switch, a “release” or “deactivate” switch, and a power supply. A first solenoid valve is in electrical communication with the activate switch and a second solenoid valve is in electrical communication with the deactivate switch. A pneumatic latching valve is in pneumatic communication with the first and second solenoid valves and a source of pressurized control and supply air is in pneumatic communication with the pneumatic latching valve and the solenoid valves. A terminal device, e.g., a spring brake, is in pneumatic communication with the latching valve, and the device is released or applied in response to pressurized supply air delivered to the device through the pneumatic latching valve in response to pneumatic control signals delivered to the pneumatic latching valve from the solenoid valves.

Abstract: Three elements of a fluid flow control device—switch, button, label—are designed to minimize the possibility of two labeled buttons being swapped on their switches. If the parts are assembled incorrectly or mislabeled, or if the buttons are thereafter swapped on the switches, it will be very obvious; then, if one attempts to fix such a problem, it can only be fixed by placing the buttons on the correct switches, and it can not be fixed by leaving the buttons on the wrong switches.

Abstract: Apparatus comprising a control member for a valve for controlling a vehicle brake function, and an electrically operable lockout for the control member. An electronic reader associated with the lockout is operable in response to communication with a personal data device to control operation of the lockout. The reader may be used to effect credential verification of a vehicle driver and enable other functions.

Abstract: A tube fitting for a tube end has a first coupling member and a second coupling member joined with the first coupling member. A tube gripping device is disposed between the first coupling member and the second coupling member such that assembly of said first coupling member with said second coupling member to a pulled-up condition causes the tube gripping device to grip and seal the tube. The first coupling member engages an internal surface of the second coupling member to provide an indication of completed pull-up.

Abstract: A tube fitting for a tube end has a female member that cooperates with a male member. A tube gripping device in the form of a gripping ring or ferrule is retained with the female member. Upon a partial pull-up, the tube gripping device separates from the female member.

Abstract: A fitting arrangement with an adapter for use in a fitting that uses a fitting body and nut of certain commonly used dimensions as described above, while retaining the gripping capability. The adapter is a ring that seals effectively against the body, while presenting a less shallow camming mouth for engagement by a ferrule. This combination of parts enables effective tube grip, fluid seal, and vibration protection.

Abstract: A submersible electromagnetic (EM) field generator for seafloor electromagnetic surveying comprising an AC to DC converter operable to generate a DC output from an AC input and a switching module operable to generate a waveform driving signal by selectively switching the DC output. The EM field generator also comprises an antenna that is operable to generate an EM field in response to the waveform driving signal. This design approach of using a switched DC source allows square or rectangular wave EM signals to be generated which have sharp transition characteristics and which are substantially independent of the AC input characteristics.

Abstract: A fitting arrangement with an adapter for use in a fitting that uses a fitting body and nut of certain commonly used dimensions as described above, while retaining the gripping capability. The adapter is a ring that seals effectively against the body, while presenting a less shallow camming mouth for engagement by a ferrule. This combination of parts enables effective tube grip, fluid seal, and vibration protection.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a thioredoxin-like 32 kDa protein (TXNL) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract: An operator for an air flow control device includes a button mounted on a plunger. The button is indexable at forty-five degree increments on the plunger. The button has a non-circular label area that is adapted to receive a non-circular label for the operator so as to present either a diamond shape or an octagon shape to a viewer of the button. The button can have either a snap fit or a threaded connection to the plunger.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a BAP-37 as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a chloride intracellular channel 1 (CLIC1) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a retinoid X receptor as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract: One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain embodiments, the invention relates to the treatment of immune related diseases, comprising administering a compound of the invention. In certain embodiments, the invention relates to the treatment of cancer, comprising administering a compound of the invention.

Abstract: A vehicle air brake system is presented with an improved service work brake arrangement. The arrangement may provide a service work brake function or both a service work brake function and a parking brake function for the vehicle. The arrangement may provide an improved service work brake arrangement disposed within a housing for reducing the number of components and plumbing required to achieve this functionality versus prior known systems. The arrangement may utilizes a pneumatic latching valve to deliver pressurized air for applying a vehicle's service brakes. The pneumatic latching valve opens upon receiving a pneumatic control signal from an electronically controlled valve and closes upon receiving a pneumatic control signal from another source. In addition, a controller and control logic may be provided for controlling the arrangement.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a c-Myc protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract: A seal (10) includes a seal structure (130) for engagement with first (24) and second fluid components (26) in first (84) and second counterbores (88). The seal also includes a holding plate (20, 30) structure for engagement with first (81) and second surfaces (85) of the components. The holding plate structure includes one or more layers that are preferably formed with the outer layers of the seal structure (30). The seal structure preferably includes at least three abutting layers of metal, the inner layer (70) having a hardness that is selected to be greater than the hardness of the first and second outer layers (20, 30). The invention also relates to a method of achieving a metal to metal seal between two relatively hard metal components in a fluid System.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a BAP-37 as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.