Patents by Inventor Mark A. Cartwright
Mark A. Cartwright has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884724Abstract: The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.Type: GrantFiled: August 4, 2020Date of Patent: January 30, 2024Assignee: Merck Patent GmbHInventors: Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna
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Patent number: 11807677Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e g, enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: GrantFiled: December 16, 2021Date of Patent: November 7, 2023Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
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Publication number: 20220281955Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e g, enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: ApplicationFiled: December 16, 2021Publication date: September 8, 2022Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Brendon Dusel, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
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Patent number: 11345396Abstract: A modular power steering apparatus includes a rotatable shaft, which is selectively rotatable to effect turning movement of at least one vehicle wheel. A housing supports the rotatable shaft for rotation relative thereto, about a shaft axis. A first rotational input assembly is provided for transmitting a steering command from a steering member to the rotatable shaft. A second rotational input assembly is operatively connected with the rotatable shaft. The second rotational input assembly is configured to apply a rotational force to the rotatable shaft. The apparatus includes a plurality of drive stations. Each drive station is configured to selectively accept both of the first and second rotational input assemblies for operating connection to the rotatable shaft at different times.Type: GrantFiled: February 18, 2020Date of Patent: May 31, 2022Assignee: ZF ACTIVE SAFETY AND ELECTRONICS US LLCInventors: Mark A. Cartwright, Ryan L. Noerenberg
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Patent number: 11236149Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: GrantFiled: May 20, 2020Date of Patent: February 1, 2022Assignee: PRESIDENT AND FALLOWS OF HARVARD COLLEGEInventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
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Publication number: 20210253160Abstract: A modular power steering apparatus includes a rotatable shaft, which is selectively rotatable to effect turning movement of at least one vehicle wheel. A housing supports the rotatable shaft for rotation relative thereto, about a shaft axis. A first rotational input assembly is provided for transmitting a steering command from a steering member to the rotatable shaft. A second rotational input assembly is operatively connected with the rotatable shaft. The second rotational input assembly is configured to apply a rotational force to the rotatable shaft. The apparatus includes a plurality of drive stations. Each drive station is configured to selectively accept both of the first and second rotational input assemblies for operating connection to the rotatable shaft at different times.Type: ApplicationFiled: February 18, 2020Publication date: August 19, 2021Inventors: Mark A. Cartwright, Ryan L. Noerenberg
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Publication number: 20210061347Abstract: An apparatus for use in turning steerable vehicle wheels includes a rotatable shaft that is rotatable relative to the vehicle to effect turning movement of the steerable vehicle wheels. A ball nut assembly is connected with an externally threaded portion of the rotatable shaft. The ball nut assembly moves axially relative to the rotatable shaft upon rotation of the rotatable shaft relative to the ball nut assembly. A steering member is connected to the ball nut assembly and at least one steerable vehicle wheel. The steering member moves with the ball nut assembly relative to the shaft. An electrical motor is connected with the rotatable shaft. The motor is operable to effect rotation of the rotatable shaft relative to the ball nut assembly to turn the steerable vehicle wheels.Type: ApplicationFiled: January 18, 2019Publication date: March 4, 2021Inventors: Kevin E. Boyle, Mark A. Cartwright, Paul E. Jacobson, Bruce C. Noah, Benjamin W. Schoon
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Publication number: 20210054073Abstract: The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.Type: ApplicationFiled: August 4, 2020Publication date: February 25, 2021Inventors: Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna
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Patent number: 10813988Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.Type: GrantFiled: February 16, 2017Date of Patent: October 27, 2020Assignee: President and Fellows of Harvard CollegeInventors: Michael Super, Edward J. Doherty, Mark Cartwright, Des White, Alexander G. Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
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Publication number: 20200283506Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: ApplicationFiled: May 20, 2020Publication date: September 10, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Brendon Dusel, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
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Patent number: 10759856Abstract: The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.Type: GrantFiled: March 9, 2017Date of Patent: September 1, 2020Assignee: Merck Patent GmbHInventors: Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna, Vanita D. Sood, Gang Hao
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Patent number: 10696733Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: GrantFiled: August 28, 2019Date of Patent: June 30, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
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Publication number: 20200164912Abstract: An apparatus for use in turning steerable vehicle wheels includes a first steering member which is linearly movable relative to the vehicle to effect turning movement of the steerable vehicle wheels. A pinion is disposed in meshing engagement with a rack portion of the first steering member. A steering column is connected with the pinion and with a vehicle steering wheel such that rotation of the steering wheel results in linear movement of the first steering member. An electrically powered steering unit is connected to a second steering member extending generally parallel to the first steering member for providing steering assist to the steerable wheels.Type: ApplicationFiled: May 11, 2018Publication date: May 28, 2020Inventors: Kevin E. Boyle, Mark A. Cartwright, Kevin M. Tilton
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Publication number: 20190389935Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: ApplicationFiled: August 28, 2019Publication date: December 26, 2019Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Brendon DUSEL, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
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Patent number: 10487147Abstract: The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.Type: GrantFiled: March 9, 2017Date of Patent: November 26, 2019Assignee: Merck Patent GmbHInventors: Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna
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Patent number: 10435457Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: GrantFiled: August 4, 2016Date of Patent: October 8, 2019Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
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Publication number: 20180371058Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: ApplicationFiled: August 4, 2016Publication date: December 27, 2018Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Brendon Dusel, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
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Publication number: 20170253654Abstract: The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.Type: ApplicationFiled: March 9, 2017Publication date: September 7, 2017Inventors: Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna
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Publication number: 20170253653Abstract: The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.Type: ApplicationFiled: March 9, 2017Publication date: September 7, 2017Inventors: Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna, Vanita D. Sood, Gang Hao
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Publication number: 20170246281Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.Type: ApplicationFiled: February 16, 2017Publication date: August 31, 2017Inventors: Michael Super, Edward J. Doherty, Mark Cartwright, Des White, Alexander G. Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler