Patents by Inventor Mark A. Chamberlin

Mark A. Chamberlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250230456
    Abstract: Methods and compositions used to prevent or decrease reduction, or reduction and recombination, during meiosis in female sporocyte, female gametophytes, or female gametes are described herein. The compositions and methods may include silencing elements and/or use gene-editing technology to decrease or inhibit Nrf4 expression levels or activity. Further provided are compositions and methods for the production of a plant that has ovules comprising non-reduced, or non-reduced and non-recombined, gametes, and/or seeds that contain clonal maternal embryos.
    Type: Application
    Filed: January 17, 2025
    Publication date: July 17, 2025
    Inventors: Tim W. Fox, Marc C. Albertsen, Mark E. Williams, Shai J. Lawit, Mark A. Chamberlin, Ueli Grossniklaus, Gion Arco Brunner, Nina Chumak, Joana Bernardes De Asis, Frederique Pasquer
  • Publication number: 20180142251
    Abstract: Methods and compositions used to prevent or decrease reduction, or reduction and recombination, during meiosis in female sporocyte, female gametophytes, or female gametes are described herein. The compositions and methods may include silencing elements and/or use gene-editing technology to decrease or inhibit Nrf4 expression levels or activity. Further provided are compositions and methods for the production of a plant that has ovules comprising non-reduced, or non-reduced and non-recombined, gametes, and/or seeds that contain clonal maternal embryos.
    Type: Application
    Filed: May 6, 2016
    Publication date: May 24, 2018
    Inventors: Tim W. Fox, Marc C. Albertsen, Mark E. Williams, Shai J Lawit, Mark A. Chamberlin, Ueli Grossniklaus, Gion Arco Brunner, Nina Chumak, Joana Bernardes De Asis, Frederique Pasquer
  • Publication number: 20150247157
    Abstract: Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences for several Arabidopsis thaliana ovule somatic tissue-preferred promoters AT-CYP86C1, AT-PPM, AT-EXT, AT-GILT1 and AT-TT2. Also provided is a method for expressing a heterologous nucleotide sequence in a plant using a promoter sequence disclosed herein.
    Type: Application
    Filed: May 14, 2015
    Publication date: September 3, 2015
    Inventors: Mark A. Chamberlin, Shai J. Lawit
  • Publication number: 20150247156
    Abstract: Methods and compositions are provided to increase the activity/level of an RKD polypeptide or an active variant or fragment thereof in an unreduced ovule plant cell that is outside of the embryo sac. In specific embodiments, such modulation of activity/level of the RKD polypeptide promotes an egg cell-like state in an unreduced ovule plant cell that is outside of the embryo sac. Such methods and compositions can employ an expression construct comprising a RKD polypeptide or active variant or fragment thereof operably linked to an ovule tissue-preferred promoter, in particular an ovule tissue-preferred promoter that is active in at least one non-gametophyte tissue in a plant ovule and is active in an unreduced cell that is outside of the embryo sac.
    Type: Application
    Filed: May 14, 2015
    Publication date: September 3, 2015
    Inventors: Mark A. Chamberlin, Shai J. Lawit
  • Publication number: 20130180008
    Abstract: Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences for an Arabidopsis thaliana (AT SVL3) promoter. Also provided is a method for expressing a heterologous nucleotide sequence in a plant using a promoter sequence disclosed herein.
    Type: Application
    Filed: April 12, 2012
    Publication date: July 11, 2013
    Applicant: PIONEER HI BRED INTERNATIONAL INC
    Inventors: MARK A. CHAMBERLIN, SHAI J. LAWIT
  • Publication number: 20130180009
    Abstract: Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include promoter sequences with direct expression in an egg cell or embryonic cell-preferred manner. Such compositions find use in, for example, a method for expressing a heterologous nucleotide sequence in a plant; detection of specific cell types in the ovule and targeted ablation of specific cell types.
    Type: Application
    Filed: April 12, 2012
    Publication date: July 11, 2013
    Applicant: PIONEER HI BRED INTERNATIONAL INC
    Inventors: MARC C. ALBERTSEN, MARK A. CHAMBERLIN, TIMOTHY W. FOX, SHAI J. LAWIT, BRIAN R. LOVELAND
  • Publication number: 20130180010
    Abstract: Methods and compositions are provided to increase the activity/level of an RKD polypeptide or an active variant or fragment thereof in an unreduced ovule plant cell that is outside of the embryo sac. In specific embodiments, such modulation of activity/level of the RKD polypeptide promotes an egg cell-like state in an unreduced ovule plant cell that is outside of the embryo sac. Such methods and compositions can employ an expression construct comprising a RKD polypeptide or active variant or fragment thereof operably linked to an ovule tissue-preferred promoter, in particular an ovule tissue-preferred promoter that is active in at least one non-gametophyte tissue in a plant ovule and is active in an unreduced cell that is outside of the embryo sac.
    Type: Application
    Filed: April 12, 2012
    Publication date: July 11, 2013
    Applicant: PIONEER HI BRED INTERNATIONAL INC
    Inventors: Mark A. Chamberlin, Shai J. Lawit
  • Publication number: 20130180007
    Abstract: Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences for several Arabidopsis thaliana ovule somatic tissue-preferred promoters AT-CYP86C1, AT-PPM, AT-EXT, AT-GILT1 and AT-TT2. Also provided is a method for expressing a heterologous nucleotide sequence in a plant using a promoter sequence disclosed herein.
    Type: Application
    Filed: April 12, 2012
    Publication date: July 11, 2013
    Applicant: PIONEER HI BRED INTERNATIONAL INC
    Inventors: Mark A. Chamberlin, Shai J. Lawit
  • Publication number: 20110119795
    Abstract: Artificial plant minichromosomes comprising a functional centromere which specifically bind centromeric protein C (CENPC) and methods for making such minichromosomes are described.
    Type: Application
    Filed: September 30, 2010
    Publication date: May 19, 2011
    Inventors: EVGUENI ANANIEV, Olga N. Danilevskaya, MARK A. CHAMBERLIN, WILLIAM J. GORDON-KAMM, SERGEI SVITASHEV, CHENGCANG WU
  • Publication number: 20090165176
    Abstract: Artificial plant minichromosomes comprising a functional centromere which specifically bind centromeric protein C (CENPC) and methods for making such minichromosomes are described.
    Type: Application
    Filed: July 29, 2008
    Publication date: June 25, 2009
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Evgueni Ananiev, Olga N. Danilevskaya, Mark A. Chamberlin, William J. Gordon-Kamm, Sergei Svitashev, Chengcang C. Wu
  • Publication number: 20090100550
    Abstract: Artificial plant minichromosomes comprising a functional centromere which specifically bind centromeric protein C (CENPC) and methods for making such minichromosomes are described.
    Type: Application
    Filed: June 20, 2008
    Publication date: April 16, 2009
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Evgueni Ananiev, Mark A. Chamberlin, William J. Gordon-Kamm, Sergei Svitashev, Chengcang Wu
  • Publication number: 20070271629
    Abstract: Artificial plant minichromosomes comprising a functional centromere which specifically bind centromeric protein C (CENPC) and methods for making such minichromosomes are described.
    Type: Application
    Filed: May 17, 2007
    Publication date: November 22, 2007
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: Evgueni Ananiev, Mark A. Chamberlin, William J. Gordon-Kamm, Sergei Svitashev, Chengcang Wu
  • Patent number: 6905857
    Abstract: Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3?-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid sequence encoding a ZmRAD51 fusion protein, as well as the use of the plasmids to introduce the ZmRAD51 coding sequence into a host cell, such as maize cell, are also disclosed.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: June 14, 2005
    Assignees: Pioneer Hi-Bred International, Inc., Trustees of Columbia University in the City of New York
    Inventors: Benjamin A. Bowen, Mark A. Chamberlin, Bruce J. Drummond, John A. McElver, Rodney J. Rothstein
  • Publication number: 20030097680
    Abstract: Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3′-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid sequence encoding a ZmRAD51 fusion protein, as well as the use of the plasmids to introduce the ZmRAD51 coding sequence into a host cell, such as maize cell, are also disclosed.
    Type: Application
    Filed: September 18, 2002
    Publication date: May 22, 2003
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: Benjamin A. Bowen, Mark A. Chamberlin, Bruce J. Drummond, John A. McElver, Rodney J. Rothstein
  • Patent number: 6541684
    Abstract: Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3′-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid sequence encoding a ZmRAD51 fusion protein, as well as the use of the plasmids to introduce the ZmRAD51 coding sequence into a host cell, such as maize cell, are also disclosed.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: April 1, 2003
    Assignees: Trustees of Columbia University in the City of New York, Pioneer Hi-Bred International, Inc.
    Inventors: Benjamin A. Bowen, Mark A. Chamberlin, Bruce J. Drummond, John A. McElver, Rodney J. Rothstein