Abstract: Here, we identify Plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multi-protein scaffold network for TCR-mediated JNK1 activation in CD8+ T-cells. Disruption of the POSH/JIP-1 complex led to profound defects in the activation of JNK1, as well as deficient activation or induction of the transcription factors c-Jun, T-bet and Eomesodermin. Furthermore, disruption of the POSH/JIP complex in CD8+ T-cells resulted in impaired proliferation, decreased cytokine expression and the inability to control tumors. Collectively, these data identify a mechanism for the specific regulation of TCR-dependent JNK1 activation and function that is key for CD8+ T-cell responses. A group of compounds are described that individually or in concert target a common set of biological pathways important in T cell function, activation of innate inflammation, ischemic reperfusion injury, HIV release and oncogenesis.

Abstract: A refrigerated case includes a body having a left and a right side, a top, and a back. A refrigerated compartment is located within the body. A number of shelves are within the refrigerated compartment. A base compartment is below the refrigerated compartment. A dividing wall separates the base compartment from the refrigerated compartment. A refrigeration module is located within the base compartment. A support member intermediate to the left and right sides supports the shelves. A transverse beam supports the support member.

Abstract: The display space of a multiple door display merchandiser is illuminated by one or more vertically extending lamps (80) disposed intermediate the vertical sides of an access opening to the display space. A multiple door assembly (44) covers the access opening. To enhance the illumination of the display space, a pair of vertically extending side reflectors (92) are provided, one extending along one side of the access opening and the other extending along the other side of the access opening. An additional reflector may be mounted to an interior facing surface of the door along an upper front region of the door and/or a lower front region.

Abstract: A refrigeration apparatus having an evaporator fan motor control includes an evaporator to remove heat energy from the air in a cooled storage space. The evaporator transfers the heat energy to a refrigerant. At least one evaporator fan moves air from the cooled storage space across the evaporator to improve the transfer of heat energy into the refrigerant. The one or more evaporator fans have an energy consumption and generate a waste heat energy. A refrigeration control unit at least controls the operation of the one or more evaporator fans. During an off mode, the one or more evaporator fans are operated in a reduced energy consumption mode to reduce the energy consumption of the one or more evaporator fans and to reduce the waste heat while still defrosting the evaporator in the off mode.

Abstract: Illumination of the interior product display space of a cold beverage merchandizer is enhanced by: a first reflector (90) disposed along a lower front region of the interior product display space at the front of the cabinet; a second reflector (92) disposed in the upper front region of the interior display space in operative association with a lamp (80); a third reflector (94) disposed in a side front region of the interior display space at a side and front of the cabinet; a fourth reflector (94) disposed in a side front region of the interior display space at a side and front of the cabinet opposite the third reflector, a fifth reflector (96) mounted to an interior facing surface of the door bounding the upper front region of the interior display space, and a sixth reflector (98) mounted to an interior facing surface of the door.

Abstract: A heat exchanger includes an inlet header, an outlet header and a plurality of flat, multi-channel heat exchange tubes extending therebetween. A longitudinally extending member divides the interior of the header into a first chamber on one side thereof for receiving a fluid and a second chamber on the other side thereof. A plurality of multi-channel heat exchange tubes extend between the headers with the respective inlet end of each heat exchange tube passing into the second chamber of the inlet header. Fluid passes through a series of longitudinally spaced openings in the longitudinally extending member for distribution to the inlets to the channels of the multi-channel heat exchange tubes. The fluid may undergo expansion as it passes through the openings.

Abstract: A thermal insulating glass door includes a multi-panel glass panel assembly having a non-structural, protective trim abutting the peripheral edge of the glass panel assembly and extending along the perimeter of the glass panel assembly, and a pair of hinge brackets mounted to one side of said glass panel assembly in spaced relationship, and a handle on the glass panel assembly on the free-swinging side of the door. The non-structural, protective trim, the handle and the hinge brackets are adhesively bonded to the glass panel assembly using double sided adhesive tape.

Abstract: A heat exchanger includes an inlet header, an outlet header and a plurality of flat, multi-channel heat exchange tubes extending therebetween. A longitudinally extending member divides the interior of the header into a first chamber on one side thereof for receiving a fluid and a second chamber on the other side thereof. A plurality of multi-channel heat exchange tubes extend between the headers with the respective inlet end of each heat exchange tube passing into the second chamber of the inlet header. Fluid passes through a series of longitudinally spaced openings in the longitudinally extending member for distribution to the inlets to the channels of the multi-channel heat exchange tubes. The fluid may undergo expansion as it passes through the openings.

Abstract: The display space of a multiple door display merchandiser is illuminated by one or more vertically extending lamps (80) disposed intermediate the vertical sides of an access opening to the display space. A multiple door assembly (44) covers the access opening. To enhance the illumination of the display space, a pair of vertically extending side reflectors (92) are provided, one extending alon one side of the access opening and the other extending along the other side of the access opening. An additional reflector may be mounted to an interior facing surface of the door along an upper front region of the door and/or a lower front region.

Abstract: A screw compressor is provided with a discharge chamber that receives alternating flows of compressed fluid from two compression chambers located on opposed sides of the screw compressor. The discharge chamber is provided with a central baffle plate separating the two flows. The baffle plate changes the fluid frequency of the system, and ensures that the fluid system will not operate at a frequency that approaches the natural frequency of the overall compressor, thus reducing undesirable vibrations. The baffle plate also reduces the magnitude of the fluctuations and the resultant noise.

Abstract: A compressor for compressing refrigerant in an air conditioning or refrigeration system, including a housing having a suction port, a discharge port, and a compression chamber, a mechanism for producing a compression cycle for compressing the refrigerant, wherein the compression cycle occurs in the suction port, discharge port and compression chamber, and a mechanism for providing liquid refrigerant into the compression cycle at a desired location for reducing pressure pulsations and associated radiated noise produced during the compression cycle.

Abstract: An absorptive and reactive muffler includes an annular flow path for the gas with the center of the annulus having a plurality of resonators which are in open communication with the downstream end of the annular flow path and make up the reactive portion of the muffler. The flow path is at least partially lined by an absorptive material overlain by a perforate material and makes up the absorptive portion of the muffler.

Abstract: A muffler includes an annular flow path for the gas with the center of the annulus having a plurality of resonators which are in open communication with the downstream end of the annular flow path. The flow path is at least partially lined by an absorptive material overlain by a perforate material.

Abstract: The entire discharge flow in a high side, vertical, hermetic rotary compressor is directed into the oil sump which generates foam for sound attenuation and heats the oil to reduce its viscosity and to drive off refrigerant dissolved in the oil.

Abstract: The gas flow direction and the noise generation direction are in opposite directions in the suction muffler. The flow path in the muffler has a number of changes in direction and the flow path cross section decreases at each change of direction in the direction of flow.

Abstract: A method for coating surfaces of a screw machine. The method includes the steps of providing at least one of a plurality of screw machine components including a rotor housing having at least a pair of parallel, overlapping bores; at least a conjugate pair of intermeshing rotors located in the bores, wherein each of the rotors has helical lobes having radially outward tip portions and intervening radially inward root portions; rough coating a surface of at least one of the plurality of components with a conformable coating, wherein the coating is substantially unevenly applied to the surface and has variable thickness over said surface; and leveling the conformable coating to a substantially uniform thickness prior to final assembly of the plurality of components, the substantially uniform thickness selected to ease assembly of the components, while maintaining coating performance criteria.

Abstract: A compressor for compressing refrigerant in an air conditioning or refrigeration system, including a housing having a suction port, a discharge port, and a compression chamber, a mechanism for producing a compression cycle for compressing the refrigerant, wherein the compression cycle occurs in the suction port, discharge port and compression chamber, and a mechanism for providing liquid refrigerant into the compression cycle at a desired location for reducing pressure pulsations and associated radiated noise produced during the compression cycle.

Abstract: A plug or plenum fan is located near two walls of the plenum such that they tend to act as the scroll for the fan. Additionally, a partition separates the fan from an adjacent corner further enhancing the formation of a scroll while providing a flow passage and a location for at least a part of the active noise control structure.

Abstract: An annular isolator is provided having a metal tube which acts as a spring while defining a flow path and a resilient member located between two loading plates. The resilient member supports the weight of one of the members being coupled and the tube acts as spring as to transmitting vibration.

Abstract: The angular extent of the flow path in a fan scroll is extended by reducing the rate of radial expansion of the flow path. By extending the angular as circumferential extent of the scroll flow path downstream of the fan impeller ANC structure can be located in/on the scroll while being located a sufficient distance downstream of the impeller. The flow path length can be increased without increasing the cubage of the scroll and, if desired, a further flow path increase can be achieved by a combination of the reduced rate of radial expansion together with increasing the cubage.