Patents by Inventor Mark A. Doty

Mark A. Doty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of submicron sized nanoparticles via dispersion lyophilization
    Patent number: 6835396
    Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: December 28, 2004
    Assignee: Baxter International Inc.
    Inventors: Sean Brynjelsen, Mark Doty, James E. Kipp, Nailesh Jayswal, Krishnaswamy Narayanan
  • Preparation and use of a stable formulation of allosteric effector compounds
    Publication number: 20030232887
    Abstract: A pharmaceutical composition of 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-propionic acid or its physiologically acceptable salts suitable for parenteral administration includes an aqueous formulation of 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-propionic acid or its physiologically acceptable salt and a buffer to maintain the pH from about 6 to about 11. The composition in accordance with the invention reduces the amount of particulate matter that forms in solution after heat sterilization. The invention also includes a process for making a pharmaceutical composition of 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-propionic acid or its physiologically acceptable salt that has a shelf life in excess of thirty days and is useful in parenteral administration.
    Type: Application
    Filed: April 10, 2002
    Publication date: December 18, 2003
    Inventors: Douglas Giles Johnson, Mark Doty, James E. Kipp
  • Preparation of submicron sized nanoparticles via dispersion lyophilization
    Publication number: 20030059472
    Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.
    Type: Application
    Filed: June 26, 2002
    Publication date: March 27, 2003
    Inventors: Sean Brynjelsen, Mark Doty, James E. Kipp, Nailesh Jayswal, Krishnaswamy Narayanan