Abstract: A bacterium of the class Clostridia comprising a heterologous nucleic acid molecule encoding at least one antigen, wherein the bacterium is capable of expressing the antigen in an intracellular compartment of the bacterium during anaerobic cell growth, and wherein at least one antigen is an infectious agent antigen or a tumour antigen.

Abstract: Systems and methods fine-tune a pretrained machine learning model. For a model having multiple layers, an initial set of configurations is identified, each configuration establishing layers to be frozen and layers to be fine-tuned. A configuration that is optimized with respect to one or more parameters is selected, establishing a set of fine-tuning layers and a set of frozen layers. An input for the model is provided to a remote system. An output of the set of frozen layers of the model, given the provided input, is received back and locally stored. The set of fine-tuning layers of the model is loaded from the remote system. The model is fine-tuned by retrieving the locally stored output of the set of frozen layers, and updating weights associated with the set of fine-tuning layers of the machine learning model.

Abstract: Disclosed herein are techniques for using a generative adversarial network (GAN) to train a semantic parser of a dialog system. A method described herein involves accessing seed data that includes seed tuples. Each seed tuple includes a respective seed utterance and a respective seed logical form corresponding to the respective seed utterance. The method further includes training a semantic parser and a discriminator in a GAN. The semantic parser learns to map utterances to logical forms based on output from the discriminator, and the discriminator learns to recognize authentic logical forms based on output from the semantic parser. The semantic parser may then be integrated into a dialog system.

Abstract: A method for tailoring a document for viewing on a mobile device includes obtaining residence information for an individual who is required to sign the document. The document is tailored to the residence of the individual. This includes hiding or condensing one or more portions of the document that pertain to laws in other jurisdictions. The document is permitted to be accessible by the mobile device.

Abstract: A method, system, and apparatus for monitoring a magnetic field related to magnetic stimulation may be provided. A system for monitoring a pulsing magnetic field related to magnetic stimulation therapy may include a magnetic stimulation component, a sensor, and a processor. The magnetic stimulation component may be configured to generate the pulsing magnetic field for the magnetic stimulation therapy. The sensor may be configured to generate a signal associated with the pulsing magnetic field. The processor may be configured to estimate a first characteristic associated with a first peak of the signal, estimate a second characteristic associated with a second peak of the signal, and determine a third characteristic of the signal based on the first characteristic and the second characteristic. The processor may be configured to determine whether a failure occurred based on the third characteristic of the signal.

Abstract: An inflatable penile prosthesis can include, a reservoir, an inflatable member and a pump assembly. The pump assembly can include at least one valve comprising an entry portion, a middle portion, an exit portion, and exit tube interface, and a valve member. The exit portion can include a first landing portion including an interior portion, the interior portion of the first landing portion being semicircular about a longitudinal exit axis, the longitudinal exit axis extending through a center of the exit portion parallel to a direction that an exit tube interface extends from the exit portion, and a first channel portion adjacent to the first landing portion and including an interior portion, the interior portion of the first channel portion being farther from the longitudinal exit axis than the interior portion of the first landing portion.

Abstract: A system includes a memory comprising a first preference profile and a second preference profile, a correlation module configured to determine a correlation value between the first preference profile and the second preference profile, and a module configured to take an action as a function of the correlation value. The action is changing a physical configuration of signage from a first physical configuration to a second physical configuration.

Abstract: An augmentation and feature caching subsystem is described for training AI/ML models. In one particular aspect, a method is provided that includes receiving data comprising training examples, one or more augmentation configuration hyperparameters and one or more feature extraction configuration hyperparameters; generating a first key based on one of the training examples and the one or more augmentation configuration hyperparameters; searching a first key-value storage based on the first key; obtaining one or more augmentations based on the search of the first key-value storage; applying the obtained one or more augmentations to the training examples to result in augmented training examples; generating a second key based on one of the augmented training examples and the one or more feature extraction configuration hyperparameters; searching a second key-value storage based on the second key; obtaining one or more features based on the search of the second key-value storage.

Abstract: An atomizer for applying a coating includes a nozzle plate, an actuator, and an acoustic focusing device. The nozzle plate defines at least one aperture. The actuator is configured to oscillate to form pressure waves within a fluid to eject the fluid from the nozzle plate. The acoustic focusing device focuses the pressure waves toward the apertures.

Abstract: A method of performing peritoneal dialysis (PD), the method comprising: delivering a PD fluid to the peritoneal cavity of a patient through a PD catheter; dwelling the PD fluid within the peritoneal cavity; and while dwelling the PD fluid, removing a biofilm from the PD catheter wall using a biofilm removing solution. The biofilm removing solution comprises: sodium citrate dihydrate; citric acid anhydrous; sodium lauryl sulfate; and water. In another aspect, a method for decontaminating a peritoneal dialysis (PD) catheter and removing a biofilm from the PD catheter and a transfer set, the method comprising: providing a biofilm removing solution; transferring the biofilm removing solution into a syringe; connecting the syringe to a transfer set of the PD catheter; and filling the transfer set and the PD catheter with the biofilm removing solution.

Abstract: The invention relates methods for diagnosing patients with multiple sclerosis by detecting cell free nucleosomes as biomarkers in body fluid samples.

Abstract: A method of performing peritoneal dialysis (PD), the method comprising: delivering a PD fluid to the peritoneal cavity of a patient through a PD catheter; dwelling the PD fluid within the peritoneal cavity; and while dwelling the PD fluid, removing a biofilm from the PD catheter wall using a biofilm removing solution. The biofilm removing solution comprises: sodium citrate dihydrate; citric acid anhydrous; sodium lauryl sulfate; and water. In another aspect, a method for decontaminating a peritoneal dialysis (PD) catheter and removing a biofilm from the PD catheter and a transfer set, the method comprising: providing a biofilm removing solution; transferring the biofilm removing solution into a syringe; connecting the syringe to a transfer set of the PD catheter; and filling the transfer set and the PD catheter with the biofilm removing solution.

Abstract: The present disclosure provides bifunctional compounds as HPK1 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by HPK1.

Abstract: A method of controlling application of at least one material onto a substrate includes configuring a material applicator having an array plate with an applicator array. The applicator array has a plurality of micro-applicators with a first subset of micro-applicators and a second subset of micro-applicators. Each of the plurality of micro-applicators has a plurality of apertures through which fluid is ejected. The first subset of micro-applicators and the second subset of micro-applicators are individually addressable, and a liquid flows through the first subset of micro-applicators and a shaping gas, e.g., air, flows through the second subset of micro-applicators. The flow of shaping gas shapes the flow of the liquid from the first subset of micro-applicators to the substrate.

Abstract: Techniques for data augmentation for training chatbot systems in natural language processing. In one particular aspect, a method is provided that includes generating a list of values to cover for an entity, selecting utterances from a set of data that have context for the entity, converting the utterances into templates, where each template of the templates comprises a slot that maps to the list of values for the entity, selecting a template from the templates, selecting a value from the list of values based on the mapping between the slot within the selected template and the list of values for the entity; and creating an artificial utterance based on the selected template and the selected value, where the creating the artificial utterance comprises inserting the selected value into the slot of the selected template that maps to the list of values for the entity.

Abstract: According to an aspect, an inflatable penile prosthesis includes a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer the fluid between the fluid reservoir and the inflatable member. The pump assembly includes a pump bulb, a valve body, a valve disposed within the valve body, a first fluid port configured to be fluidly coupled to the fluid reservoir, and a second fluid port configured to be fluidly coupled to the inflatable member. The valve is configured to move between an inflation position and a deflation position. The valve includes a first member and second member, the first member being configured to move with respect to the second member.

Abstract: Techniques are provided for using context tags in named-entity recognition (NER) models. In one particular aspect, a method is provided that includes receiving an utterance, generating embeddings for words of the utterance, generating a regular expression and gazetteer feature vector for the utterance, generating a context tag distribution feature vector for the utterance, concatenating or interpolating the embeddings with the regular expression and gazetteer feature vector and the context tag distribution feature vector to generate a set of feature vectors, generating an encoded form of the utterance based on the set of feature vectors, generating log-probabilities based on the encoded form of the utterance, and identifying one or more constraints for the utterance.

Abstract: In one aspect of the present disclosure, a system and method are provided for pairing a network-enabled movable barrier operator with a transmitter. The method may include receiving a pairing request, retrieving a hashed version of the transmitter fixed code, verifying access authorization, and forwarding the hashed version of the transmitter fixed code to a movable barrier operator to allow the movable barrier operator to determine whether a new transmitter is authorized to control the movable barrier operator.

Abstract: Novel techniques are described for data augmentation using a two-stage entity-aware augmentation to improve model robustness to entity value changes for intent prediction.

Abstract: Novel techniques are described for positive entity-aware augmentation using a two-stage augmentation to improve the stability of the model to entity value changes for intent prediction. In one particular aspect, a method is provided that includes accessing a first set of training data for an intent prediction model, the first set of training data comprising utterances and intent labels; applying one or more positive data augmentation techniques to the first set of training data, depending on the tuning requirements for hyper-parameters, to result in a second set of training data, where the positive data augmentation techniques comprise Entity-Aware (“EA”) technique and a two-stage augmentation technique; combining the first set of training data and the second set of training data to generate expanded training data; and training the intent prediction model using the expanded training data.