Patents by Inventor Mark A. Farrell

Mark A. Farrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12266453
    Abstract: Disclosed is a lid (10) for closing a receptacle (20), the lid comprising: a static portion (18) arranged to substantially match an opening of the receptacle to be closed; a plurality of pivoting arms (11) coupled to the static portion; means (12) for moving the plurality of pivoting arms between a first position wherein the plurality of pivoting arms lie within a perimeter of the static portion and a second position wherein the plurality of pivoting arms lie outside a perimeter of the static portion and engage with a complementary feature of the receptacle.
    Type: Grant
    Filed: July 3, 2020
    Date of Patent: April 1, 2025
    Assignee: CAPSA SOLUTIONS LIMITED
    Inventors: James Hill, Mark Farrell
  • Patent number: 12227772
    Abstract: The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of vitamin D3. The invention further relates to a yeast strain expressing said modified enzymes and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: February 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Christopher Mark Farrell, Lisa Ann Laprade, Otto Martin Lehmann, Joshua Trueheart
  • Patent number: 12150974
    Abstract: The present disclosure provides conjugates, methods of making the same, and uses thereof. The conjugates of the present technology are useful in inducing anergy in insulin-binding B cells.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: November 26, 2024
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Kyle Apley, Mark Farrell, Cory Berkland
  • Publication number: 20240279706
    Abstract: The present invention is related to a novel process for production of retinyl acetate in a host cell, particularly oleaginous yeast such as e.g. Yarrowia, wherein the product purity could be increased with reduction of unwanted side-products. Particularly, the novel process comprises fermentation in the presence of ethanol, such as e.g. in a fed-batch fermentation process. Such process is especially useful in a biotechnological process for production of vitamin A.
    Type: Application
    Filed: July 27, 2021
    Publication date: August 22, 2024
    Inventors: Peter Louis HOUSTON, Valmik Kanubhai VYAS, Anna SYMBOR-NAGRABSKA, Reed Chadbourne DOTEN, Christopher Mark FARRELL, Ethan LAM
  • Publication number: 20240269239
    Abstract: The present disclosure provides conjugates, methods of making the same, and uses thereof. The conjugates of the present technology are useful in inducing anergy in insulin-binding B cells.
    Type: Application
    Filed: January 27, 2022
    Publication date: August 15, 2024
    Inventors: Kyle APLEY, Mark FARRELL, Cory BERKLAND
  • Patent number: 12049617
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: July 30, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Christopher Mark Farrell, Lisa Ann Laprade, Otto Martin Lehmann, Joshua Trueheart, Bastien Jean Wolfgang Chevreux
  • Patent number: 12018309
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified host strains expressing enzymes having improved C-5 sterol 5 desaturase activity and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: June 25, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Christopher Mark Farrell, Lisa Ann Laprade, Otto Martin Lehmann, Joshua Trueheart, Bastien Jean Wolfgang Chevreux
  • Patent number: 11487547
    Abstract: A method is provided that is executable by a processor of a computer. Note that the processor is communicatively coupled to a memory of the computer, and the memory stores a response block of a call command. In implementing the method, the processor defines a sub-functions field in the response block of the call command. Further the processor indicates that a set of functions of a set of instructions are installed and available at an interface based on a corresponding sub-functions flag within the sub-functions field being set. Note that the interface is also being executed on the computer and that the set of functions being represented by the corresponding sub-functions flag. The processor further indicates that the set of functions of the set of instructions are not installed based on the corresponding sub-functions flag not being set.
    Type: Grant
    Filed: April 7, 2021
    Date of Patent: November 1, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Louis P. Gomes, Bruce Giamei, Timothy Siegel, Mark Farrell, Matthias Klein
  • Publication number: 20220254534
    Abstract: Disclosed is a lid (10) for closing a receptacle (20), the lid comprising: a static portion (18) arranged to substantially match an opening of the receptacle to be closed; a plurality of pivoting arms (11) coupled to the static portion; means (12) for moving the plurality of pivoting arms between a first position wherein the plurality of pivoting arms lie within a perimeter of the static portion and a second position wherein the plurality of pivoting arms lie outside a perimeter of the static portion and engage with a complementary feature of the receptacle.
    Type: Application
    Filed: July 3, 2020
    Publication date: August 11, 2022
    Inventors: James HILL, Mark FARRELL
  • Publication number: 20220010291
    Abstract: The present invention is related to an improved process for production of vitamin B2 using a genetically engineered host cell comprising a heterologous enzyme with pyridoxal phosphatase activity. Using said modified host cell, the yield of riboflavin production could be increased by at least about 5%.
    Type: Application
    Filed: November 11, 2019
    Publication date: January 13, 2022
    Inventors: Christopher Mark FARRELL, Sébastien Eric POTOT, Zoltán PRÁGAI, Michael Patrick ANAYA
  • Patent number: 11158997
    Abstract: A spark plug for use with an engine block/cylinder head having a threaded bore and also for use with a spark plug wrench and an ignition wire. Also, an improved method for constructing a spark plug, the spark plug including a metal shell having a hex nut, a seat, a flange, a bore and threads. A ground electrode is associated with the shell and an insulator assembly occupies the bore and is gripped by the flange. The method includes the steps of forming the hex nut and the seat by carrying out operations on a blank, roiling the threads, fitting the insulator assembly into the bore, deforming the flange to capture the insulator, and forming the negative electrode by machining the blank.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: October 26, 2021
    Assignee: NANO SPARK, INC.
    Inventors: Thomas L. Herriges, Mark Farrell, Ghabi Neame, Robert Keith Sim, Carlos Fernandes, Harry E. Ruda
  • Publication number: 20210238539
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.
    Type: Application
    Filed: May 21, 2019
    Publication date: August 5, 2021
    Inventors: Christopher Mark FARRELL, Lisa Ann LAPRADE, Otto Martin LEHMANN, Joshua TRUEHEART, Bastien Jean Wolfgang CHEVREUX
  • Publication number: 20210222222
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified host strains expressing enzymes having improved C-5 sterol 5 desaturase activity and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Application
    Filed: May 21, 2019
    Publication date: July 22, 2021
    Inventors: Christopher Mark FARRELL, Lisa Ann LAPRADE, Otto Martin LEHMANN, Joshua TRUEHEART, Bastien Jean Wolfgang CHEVREUX
  • Publication number: 20210224073
    Abstract: A method is provided that is executable by a processor of a computer. Note that the processor is communicatively coupled to a memory of the computer, and the memory stores a response block of a call command. In implementing the method, the processor defines a sub-functions field in the response block of the call command. Further the processor indicates that a set of functions of a set of instructions are installed and available at an interface based on a corresponding sub-functions flag within the sub-functions field being set. Note that the interface is also being executed on the computer and that the set of functions being represented by the corresponding sub-functions flag. The processor further indicates that the set of functions of the set of instructions are not installed based on the corresponding sub-functions flag not being set.
    Type: Application
    Filed: April 7, 2021
    Publication date: July 22, 2021
    Inventors: Louis P. Gomes, Bruce Giamei, Timothy Slegel, Mark Farrell, Matthias Klein
  • Patent number: 11061685
    Abstract: A method is provided that is executable by a processor of a computer. Note that the processor is communicatively coupled to a memory of the computer, and the memory stores a response block of a call command. In implementing the method, the processor defines a sub-functions field in the response block of the call command. Further the processor indicates that a set of functions of a set of instructions are installed and available at an interface based on a corresponding sub-functions flag within the sub-functions field being set. Note that the interface is also being executed on the computer and that the set of functions being represented by the corresponding sub-functions flag. The processor further indicates that the set of functions of the set of instructions are not installed based on the corresponding sub-functions flag not being set.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: July 13, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Louis P. Gomes, Bruce Giamei, Timothy Slegel, Mark Farrell, Matthias Klein
  • Patent number: 11031951
    Abstract: Embodiments of the invention are directed to a DEFLATE compression accelerator and to a method for verifying the correctness of the DEFLATE compression accelerator. The accelerator includes an input buffer and a Lempel-Ziv 77 (LZ77) compressor communicatively coupled to an output of the input buffer. A switch is communicatively coupled to the output of the input buffer and to the output of the LZ77 compressor. The switch is configured to bypass the LZ77 compressor during a compression test. The accelerator further includes a deflate Huffman encoder communicatively coupled to an output of the switch and an output buffer communicatively coupled to the deflate Huffman encoder. When the switch is not bypassed, the compressor can be modified to produce repeatable results.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: June 8, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Timothy Slegel, Mark Farrell, Bruce Giamei, Matthias Klein, Ashutosh Misra, Simon Weishaupt, Girish Gopala Kurup
  • Publication number: 20210115412
    Abstract: The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of vitamin D3. The invention further relates to a yeast strain expressing said modified enzymes and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Application
    Filed: May 21, 2019
    Publication date: April 22, 2021
    Inventors: Christopher Mark FARRELL, Lisa Ann LAPRADE, Otto Martin LEHMANN, Joshua TRUEHEART
  • Patent number: 10985778
    Abstract: Embodiments of the invention are directed to a DEFLATE compression accelerator and to a method for verifying the correctness of the DEFLATE compression accelerator. The accelerator includes an input buffer and a Lempel-Ziv 77 (LZ77) compressor communicatively coupled to an output of the input buffer. A switch is communicatively coupled to the output of the input buffer and to the output of the LZ77 compressor. The switch is configured to bypass the LZ77 compressor during a compression test. The accelerator further includes a deflate Huffman encoder communicatively coupled to an output of the switch and an output buffer communicatively coupled to the deflate Huffman encoder. When the switch is not bypassed, the compressor can be modified to produce repeatable results.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: April 20, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Timothy Siegel, Mark Farrell, Bruce Giamei, Matthias Klein, Ashutosh Misra, Simon Weishaupt, Girish Gopala Kurup
  • Patent number: 10944423
    Abstract: Embodiments of the invention are directed to a DEFLATE compression accelerator and to a method for verifying the correctness of the DEFLATE compression accelerator. The accelerator includes an input buffer and a Lempel-Ziv 77 (LZ77) compressor communicatively coupled to an output of the input buffer. A switch is communicatively coupled to the output of the input buffer and to the output of the LZ77 compressor. The switch is configured to bypass the LZ77 compressor during a compression test. The accelerator further includes a deflate Huffman encoder communicatively coupled to an output of the switch and an output buffer communicatively coupled to the deflate Huffman encoder. When the switch is not bypassed, the compressor can be modified to produce repeatable results.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: March 9, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Timothy Siegel, Mark Farrell, Bruce Giamei, Matthias Klein, Ashutosh Misra, Simon Weishaupt, Girish Gopala Kurup
  • Publication number: 20200388993
    Abstract: A spark plug for use with an engine block/cylinder head having a threaded bore and also for use with a spark plug wrench and an ignition wire. Also, an improved method for constructing a spark plug, the spark plug including a metal shell having a hex nut, a seat, a flange, a bore and threads. A ground electrode is associated with the shell and an insulator assembly occupies the bore and is gripped by the flange. The method includes the steps of forming the hex nut and the seat by carrying out operations on a blank, roiling the threads, fitting the insulator assembly into the bore, deforming the flange to capture the insulator, and forming the negative electrode by machining the blank.
    Type: Application
    Filed: August 8, 2017
    Publication date: December 10, 2020
    Inventors: Thomas L. Herriges, Mark Farrell, Ghabi Neame, Robert Keith Sim, Carlos Fernandes, Harry E. Ruda