Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Disclosed are examples of systems, apparatus, methods and computer program products for sharing and publishing files. In one aspect, the database system can maintain a user database, a file database and a library. The database system can receive a first request initiated by a first user to share a first file with one or more second users and, responsive to the first request, enable a second set of one or more permissions for each of the second users. The database system also can receive a second request initiated by the first user to publish the first file to the library and, responsive to the second request, publish the first file to the library. The database system additionally can restrict access to the published file based on permissions associated with the library.

Abstract: Systems and methods for removing carbonaceous clinker material from a coke oven are described. A coke oven can be provided including an oven floor, coke, and clinker material deposited on the oven floor. After a temperature of the coke oven has reached a first temperature (e.g., after heating coal in the oven to produce coke), the method includes increasing the temperature of the coke oven to a second temperature that is higher than the first temperature for a predetermined amount of time. After the predetermined amount of time, the temperature is reduced to a third temperature that is lower than the first temperature.

Abstract: A golf club head includes a club body including a crown, a sole, a skirt disposed between and connecting the crown and the sole and a face portion connected to a front end of the club body. The face portion includes a geometric center defining the origin of a coordinate system when the golf club head is ideally positioned, the coordinate system including an x-axis being tangent to the face portion at the origin and parallel to a ground plane, a y-axis intersecting the origin being parallel to the ground plane and orthogonal to the x-axis, and a z-axis intersecting the origin being orthogonal to both the x-axis and the y-axis. The golf club head defines a center of gravity CG, the CG being a distance CGY from the origin as measured along the y-axis and a distance CGZ from the origin as measured along the z-axis.

Abstract: An article of footwear incorporating an upper formed by a forefoot component, a knitted workpiece, and a heel component is described. Each of the forefoot component, the knitted workpiece, and the heel component are separate from each other and joined along connection areas. Reinforcement elements cover the connection areas. In one embodiment, the knitted workpiece includes a collar portion and a throat portion extending from a forward end of the collar portion. The knitted workpiece also includes a medial lobe extending from one side of the throat portion and a lateral lobe extending from an opposite side of the throat portion from the medial lobe. The collar portion, the throat portion, the medial lobe, and the lateral lobe form a single unified knitted workpiece.

Abstract: Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.

Abstract: A semiconductor device including a first dielectric layer and a second dielectric layer is formed by forming an inhibitor layer over a semiconductor material. The inhibitor layer includes at least silicon and nitrogen. The semiconductor material is heated in an oxygen-containing ambient which oxidizes the inhibitor layer and forms the first dielectric layer which includes the oxidized inhibitor layer, and oxidizes the semiconductor material to form the second dielectric layer. The second dielectric layer is thicker than, the first dielectric layer. The first dielectric layer and the second dielectric layer each include at least 90 weight percent silicon dioxide and less than 1 weight percent nitrogen. The first dielectric layer and the second dielectric layer may be used to form gate dielectric layers for a first MOS transistor and a second MOS transistor that operates at a higher voltage than the first MOS transistor.

Abstract: An article of footwear incorporating an upper formed by a forefoot component, a knitted workpiece, and a heel component is described. Each of the forefoot component, the knitted workpiece, and the heel component are separate from each other and joined along connection areas. Reinforcement elements cover the connection areas. In one embodiment, the knitted workpiece includes a collar portion and a throat portion extending from a forward end of the collar portion. The knitted workpiece also includes a medial lobe extending from one side of the throat portion and a lateral lobe extending from an opposite side of the throat portion from the medial lobe. The collar portion, the throat portion, the medial lobe, and the lateral lobe form a single unified knitted workpiece.

Abstract: An article of footwear incorporating an upper formed by a forefoot component, a knitted workpiece, and a heel component is described. Each of the forefoot component, the knitted workpiece, and the heel component are separate from each other and joined along connection areas. Reinforcement elements cover the connection areas. In one embodiment, the knitted workpiece includes a collar portion and a throat portion extending from a forward end of the collar portion. The knitted workpiece also includes a medial lobe extending from one side of the throat portion and a lateral lobe extending from an opposite side of the throat portion from the medial lobe. The collar portion, the throat portion, the medial lobe, and the lateral lobe form a single unified knitted workpiece.

Abstract: A slice manager associated with a network access point of a telecommunication network can manage combinations of network slices and bandwidth parts for user equipment (UE). The bandwidth parts can have independently set numerologies, such as subcarrier spacing values. The UE can be configured to use one or more active bandwidth parts at a time, such that the slice manager can instruct the UE to use multiple active bandwidth parts simultaneously with respect to the same network slice or multiple network slices.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A system may include one or more of a called device, a calling device, configured to call the called device, and a network module. The network module is configured to process incoming call information of a call placed to the called device and configured to route the call to a destination based on preferences of the called device.

Abstract: A bearing and/or seal assembly where pressurized gas (e.g., air) may be arranged to produce a contact-free bearing and/or seal is provided. The assembly includes a permeable body (12) including structural features (13) selectively engineered to convey a pressurized gas (Ps) from an inlet side (20) side of the permeable body to an outlet side (22) of the permeable body to form an annular film of the pressurized gas relative to the rotatable shaft. Disclosed embodiments may be produced by way of three-dimensional (3D) Printing/Additive Manufacturing (AM) technologies with practically no manufacturing variability; and may also cost-effectively and reliably benefit from the relatively complex geometries and the features and/or conduits that may be involved to, for example, form the desired distribution pattern or impart a desired directionality to the pressurized gas conveyed through the permeable body of the bearing and/or seal assembly.

Abstract: In some implementations, a controller may monitor, in connection with a fluid pump driven by a motor that is controlled by a variable frequency drive and over a time period, a torque of the motor to obtain torque data, a speed of the motor to obtain speed data, and a pressure of the fluid pump to obtain pressure data. The controller may determine that the fluid pump is associated with a leak of a particular severity level based on the torque data indicating a deviation that satisfies a first threshold, the speed data indicating a deviation that satisfies a second threshold, and the pressure data indicating a deviation that satisfies a third threshold. The controller may perform at least one operation based on the particular severity level of the leak.

Abstract: In some implementations, a controller may obtain a set of measurement values associated with the dual-pump single-power source system, wherein the set of measurement values includes at least one of one or more speed measurements associated with a clutch that is coupled to a power source and a first pump of the dual-pump single-power source system, a measurement value indicating an output speed of the power source, or a first crank angle associated with the first pump and a second crank angle associated with a second pump of the dual-pump single-power source system. The controller may detect that the clutch is experiencing slippage based on comparing at least two measurement values of the set of measurement values. The controller may perform an action to cause the clutch to disengage a mechanical connection between the first pump and the power source while the power source is running and is mechanically connected to the second pump.

Abstract: An optical device includes a stack that includes a first curved optical element stacked with a second curved optical element. The second curved optical element propagates light by total internal reflection. The stack also includes an incoupling diffractive grating that incouples the light into the second optical element and an outcoupling diffractive grating optically coupled to the incoupling diffractive grating through the second curved optical element. The outcoupling diffractive grating directs the light. The first curved optical element has a first refractive index, the second curved optical element has a second refractive index, and the first refractive index is different from the second refractive index by approximately 0.15 to 1.2.

Abstract: In some implementations, a controller may obtain an indication of a first crank angle associated with a first pump, of a dual-pump single-power source system, that is mechanically connected to a power source of the dual-pump single-power source system via a first clutch. The controller may obtain an indication of a second crank angle associated with a second pump, of the dual-pump single-power source system, that is mechanically connected to the power source via a second clutch. The controller may determine that a difference between the first crank angle and the second crank angle is outside of a tolerance of a crank angle difference value. The controller may modulate a fluid pressure associated with at least one of the first clutch or the second clutch to cause the difference between the first crank angle and the second crank angle to be within the tolerance of the crank angle difference value.

Abstract: Systems and methods are disclosed for producing multi-layer meltblown mats. The method includes depositing first meltblown fibers onto a first moving surface such as a conveyor belt to form a first layer of meltblown fibers, and depositing second meltblown fibers onto a second moving surface such as a conveyor belt to form a second layer of meltblown fibers. The first and second layers of meltblown fibers are fed through opposed rollers to form combined meltblown layers comprising the first layer of meltblown fibers and the second layer of meltblown fibers. The combined meltblown layers are bonded together to produce a bonded multi-layer meltblown sheet. The bonded multi-layer meltblown sheet has a first outer exposed surface formed by contact of the first layer of meltblown fibers with the first moving surface, and a second outer exposed surface formed by contact of the second layer of meltblown fibers with the second moving surface.

Abstract: A process of manipulating a closable carton with lid panels extending from walls of the carton and tabs received in slots formed in the lid panels to secure the lid panels to close the carton. The process has a step of moving a folding element transverse to each wall from which a lid extends to move the one or more lids into a position which closes the carton. The process has a step of lifting the closed carton past a non-return support and into engagement with another carton to provide a stack of closed cartons supported by the non-return support. The process has a step of the support then releasing a stack of closed cartons to a conveyor.