Abstract: This invention provides minimally invasive methods, reagents, diagnostic and prognostic markers useful for staging, prognosis and surveillance of colorectal cancers, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.

Abstract: An insertion shaft for an electrically actuated scope includes at least two wires. Each wire has a proximal end anchored to a respective proximal anchoring point and a distal end anchored to a respective distal anchoring point. The wires are disposed around a central axis and extend along the insertion shaft. Each of the wires comprises two-way memory material configured to contract when heated to or above a first predetermined temperature and return to a predetermined original length thereof upon cooling to or below a second predetermined temperature below the first predetermined temperature. The length of each wire is larger than a length along the insertion shaft between the proximal anchoring point and the distal anchoring point to which the wire is anchored, such that each of the wires is incorporated in the insertion shaft with a predetermined slack.

Abstract: Voltage regulated electrolytic water purification methods and systems are provided. The methods and systems utilize a series of deflocculation tanks each containing a series of electrodes and a bubbler to remove contaminants from water. The water purification methods and systems increase the life of the electrodes, allowing for reduced maintenance.

Abstract: Systems and method are disclosed for distributed data processing across multiple compute resources. For example, the system may comprise a ticker plant configured to receive streaming financial market data events from a plurality of feeds, the events comprising financial market data pertaining to financial instruments. The ticker plant may comprise a processor, an FPGA, and a shared memory, wherein the shared memory is shared between the processor and the FPGA, wherein the processor is configured to execute software to manage a flow of financial market data derived from the streaming events between the processor and the FPGA via DMA transfers of the financial market data between the processor and the FPGA via the shared memory, and wherein the FPGA comprises reconfigurable hardware that is configured to perform processing operations on the financial market data to generate processed financial market data for delivery to data consumers.

Abstract: Systems and methods are disclosed for routing of streaming data as between multiple compute resources. For example, the system may comprise a processor, a field programmable gate array (FPGA), a shared memory that is shared by a user space of an operating system for the processor and the FPGA, a network protocol stack, and driver code for execution by the processor. The driver code can be configured to (1) make the received streaming data available to a user mode software application for processing, (2) make data stored in the shared memory available to the FPGA via DMA transfers of data from the shared memory into the FPGA for processing thereby, (3) receive a stream of processed data from the FPGA, and (4) provide the received processed data to the network protocol stack for delivery to one or more data consumers.

Abstract: Systems and methods are disclosed for routing of streaming data as between multiple compute resources. For example, the system may comprise a processor, a field programmable gate array (FPGA), a shared memory that is shared by a user space of an operating system for the processor and the FPGA, a network protocol stack, and driver code for execution by the processor. The driver code can be configured to (1) make the received streaming data available to a user mode software application for processing, (2) make data stored in the shared memory available to the FPGA via DMA transfers of data from the shared memory into the FPGA for processing thereby, (3) receive a stream of processed data from the FPGA, and (4) provide the received processed data to the network protocol stack for delivery to one or more data consumers.

Abstract: Systems and methods are disclosed for routing of streaming data as between multiple compute resources. For example, the system may comprise a processor, a field programmable gate array (FPGA), a shared memory that is shared by a user space of an operating system for the processor and the FPGA, a network protocol stack, and driver code for execution by the processor. The driver code can be configured to (1) copy the streaming data received by the network protocol stack into the shared memory, (2) facilitate DMA transfers of the streaming data from the shared memory into the FPGA for processing thereby, (3) receive a stream of processed data from the FPGA, and (4) deliver the received processed data to the network protocol stack for delivery to one or more data consumers.

Abstract: Systems and methods are disclosed for routing of streaming data as between multiple compute resources. For example, the system may comprise a processor, a field programmable gate array (FPGA), a shared memory that is shared by a user space of an operating system for the processor and the FPGA, a network protocol stack, and driver code for execution by the processor. The driver code can be configured to (1) copy the streaming data received by the network protocol stack into the shared memory, (2) facilitate DMA transfers of the streaming data from the shared memory into the FPGA for processing thereby, (3) receive a stream of processed data from the FPGA, and (4) deliver the received processed data to the network protocol stack for delivery to one or more data consumers.

Abstract: A sustained release pharmaceutical formulation for pain management comprises an active ingredient, and a water-miscible and hygroscopic network-forming material, the active ingredient being dispersed within the water-miscible and hygroscopic network-forming material. The pharmaceutical may comprise a hydrophobic component, wherein the active ingredient dispersed within the water-miscible and hygroscopic network-forming material are together dispersed in hydrophobic component. Optionally, the pharmaceutical formulation may be combined with a reinforcing member for providing a system for sustained release of the pharmaceutical formulation for pain management.

Abstract: Systems and methods are disclosed for fast track routing of streaming data as between multiple compute resources. For example, the system may comprise a first processor, a second processor, a shared memory that is mapped into a kernel and user space of an operating system for the processor, a network protocol stack, and driver code for execution within the kernel space of the operating system while the operating system is in the kernel mode. The driver code can be configured to (1) maintain a kernel level interface into the network protocol stack, (2) copy the streaming data from the network protocol stack into the shared memory, wherein the copy operation is performed by the driver code without the operating system transitioning to the user mode, and (3) facilitate DMA transfers of data from the shared memory into the second processor for processing thereby.

Abstract: A high speed apparatus and method for processing a plurality of financial market data messages are disclosed. With respect to an exemplary embodiment, a reconfigurable logic device is employed to generate a plurality of financial market data messages from a plurality of the data fields, each generated message having a specified message format.

Abstract: Systems and methods are disclosed for fast track routing of streaming data as between multiple compute resources. For example, the system may comprise a first processor, a second processor, a shared memory that is mapped into a kernel and user space of an operating system for the processor, a network protocol stack, and driver code for execution within the kernel space of the operating system while the operating system is in the kernel mode. The driver code can be configured to (1) maintain a kernel level interface into the network protocol stack, (2) copy the streaming data from the network protocol stack into the shared memory, wherein the copy operation is performed by the driver code without the operating system transitioning to the user mode, and (3) facilitate DMA transfers of data from the shared memory into the second processor for processing thereby.

Abstract: Systems and methods are disclosed for fast track routing of streaming data as between multiple compute resources. For example, the system may comprise a processor, reconfigurable logic device, a shared memory that is mapped into a kernel and user space of an operating system for the processor, a network protocol stack, and driver code for execution within the kernel space of the operating system while the operating system is in the kernel mode. The driver code can be configured to (1) maintain a kernel level interface into the network protocol stack, (2) copy the streaming data from the network protocol stack into the shared memory, wherein the copy operation is performed by the driver code without the operating system transitioning to the user mode, and (3) facilitate DMA transfers of data from the shared memory into the reconfigurable logic device for processing thereby.

Abstract: An angular offset apparatus for determining an angular offset, or scribe line offset (SLO), of two objects within a drilling environment. The angular offset apparatus may include a sensing component and a target component located at various locations within the drilling environment. The sensing component may implement one or more sensors configured to collect data associated with the target component and the drilling environment to determine the SLO between the two objects. The angular offset apparatus, along with the calculated SLO, is designed to ensure accuracy and safety during drilling operations.

Abstract: Systems and methods are disclosed for fast track routing of streaming data as between multiple compute resources. For example, the system may comprise a processor, reconfigurable logic device, a shared memory that is mapped into a kernel and user space of an operating system for the processor, a network protocol stack, and driver code for execution within the kernel space of the operating system while the operating system is in the kernel mode. The driver code can be configured to (1) maintain a kernel level interface into the network protocol stack, (2) copy the streaming data from the network protocol stack into the shared memory, wherein the copy operation is performed by the driver code without the operating system transitioning to the user mode, and (3) facilitate DMA transfers of data from the shared memory into the reconfigurable logic device for processing thereby.

Abstract: A high speed apparatus and method for processing financial instrument order books are disclosed. With respect to an exemplary embodiment, a reconfigurable logic device is employed to synthesize quote events associated with a plurality of financial instruments from a financial market data feed.

Abstract: A method for identifying a leak in a pressure system. The method includes receiving, from a pressure sensor, pressure data of a fluid contained in the pressure system, determining a slope and curvature of the pressure data, determining a ratio of the curvature to the slope of the pressure data, and monitoring the ratio over a period of time. The method also includes, as a result of a non-constant component of the ratio exceeding a predetermined threshold, generating an indication that a leak may be present in the pressure system, or as a result of the ratio including no non-constant component or a non-constant component below the predetermined threshold, generating an indication that no leak is present in the pressure system.

Abstract: A methodology and apparatus for cutting shape(s) or profile(s) through well tubular(s), or for completely circumferentially severing through multiple tubulars, including all tubing, pipe, casing, liners, cement, other material encountered in tubular annuli. This rigless apparatus utilizes a computer controlled, downhole robotic three-axis rotary mill to effectively generate a shape(s) or profile(s) through, or to completely sever in a 360 degree horizontal plane wells with multiple, nested strings of tubulars whether the tubulars are concentrically aligned or eccentrically aligned. This is useful for well abandonment and decommissioning where complete severance is necessitated and explosives are prohibited, or in situations requiring a precise window or other shape to be cut through a single tubular or plurality of tubulars.

Abstract: A high speed apparatus and method for processing a plurality of financial market data messages are disclosed. With respect to an exemplary embodiment, a reconfigurable logic device is employed to map the symbols present in the financial market data messages to another symbology.

Abstract: An angular offset apparatus for determining an angular offset, or scribe line offset (SLO), of two objects within a drilling environment. The angular offset apparatus may include a sensing component and a target component located at various locations within the drilling environment. The sensing component may implement one or more sensors configured to collect data associated with the target component and the drilling environment to determine the SLO between the two objects. The angular offset apparatus, along with the calculated SLO, is designed to ensure accuracy and safety during drilling operations.