Abstract: Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.

Abstract: A multi-layer amnion product may include a plurality of layers oriented on top of one another, wherein the plurality of layers includes at least one chorion membrane layer and at least two amnion layers. The plurality of layers may include at least four layers and less than ten layers. At least two of the at least two amnion layers may form outermost layers of the plurality of layers. Each amnion layer may include an epithelial layer, a basement membrane, and a fibroblast layer, and each chorion layer may include a reticular layer and a basement membrane.

Abstract: An aspiration system to control vacuum pressure in an ultrasonic surgical handpiece to result in improved control responsiveness during aspiration. The system comprises a console including a vacuum pump. The system includes a cassette comprising a joint that divides a vacuum path into at least two flow paths. A first joint port couples to a first flow path. A second flow path is coupled to a second joint port, a third flow path is coupled to a third joint port, and a fourth flow path is coupled to a port on a surgical waste receiver. A first sensor senses pressure in the fourth flow path and provides a waste receiver pressure signal. A second sensor senses pressure in the third flow path and provides a tip pressure signal. The controller controls a position of a first vent valve and a second vent valve based on the waste receiver pressure signal and the tip pressure signal, respectively.

Abstract: An aspiration system to control vacuum pressure in an ultrasonic surgical handpiece to result in improved control responsiveness during aspiration. The system comprises a console including a vacuum pump. The system includes a cassette comprising a joint that divides a vacuum path into at least two flow paths. A first joint port couples to a first flow path. A second flow path is coupled to a second joint port, a third flow path is coupled to a third joint port, and a fourth flow path is coupled to a port on a surgical waste receiver. A first sensor senses pressure in the fourth flow path and provides a waste receiver pressure signal. A second sensor senses pressure in the third flow path and provides a tip pressure signal. The controller controls a position of a first vent valve and a second vent valve based on the waste receiver pressure signal and the tip pressure signal, respectively.

Abstract: A modular valve assembly is formed from multiple modular valves having a valve base and a valve actuator. Each base includes at least a first channel and a second channel and an internal passage forming an opening in the first channel so as to be in selective fluid communication with an exterior port of the valve base, and with the second channel being a through passage that is not in fluid communication with the internal passage. Adjacent valve bases are interconnectable in one of two orientations either with the first and second channels of one valve base being aligned with the first and second channels, respectively, of an adjacent valve base, or with the first and second channels of one valve base being aligned with the second and first channels, respectively, of an adjacent valve base. The valve bases may be provided with third and fourth channels for three-way operability.

Abstract: An aspiration system to control vacuum pressure in an ultrasonic surgical handpiece to result in improved control responsiveness during aspiration. The system comprises a console including a vacuum pump. The system includes a cassette comprising a joint that divides a vacuum path into at least two flow paths. A first joint port couples to a first flow path. A second flow path is coupled to a second joint port, a third flow path is coupled to a third joint port, and a fourth flow path is coupled to a port on a surgical waste receiver. A first sensor senses pressure in the fourth flow path and provides a waste receiver pressure signal. A second sensor senses pressure in the third flow path and provides a tip pressure signal. The controller controls a position of a first vent valve and a second vent valve based on the waste receiver pressure signal and the tip pressure signal, respectively.

Abstract: The present invention provides methods of reducing liver fibrosis in a human patient with a lysosomal acid lipase (LAL) deficiency comprising administering sebelipase alfa to the patient, wherein the patient has been determined to have at least a one point reduction (e.g., a ?1 point reduction or a ?2 point reduction) in Ishak fibrosis stage after administration compared to a baseline Ishak fibrosis stage obtained from the patient prior to administration. Also provided are methods of treating a human patient with a lysosomal acid lipase (LAL) deficiency comprising administering sebelipase alfa to the patient, wherein the patient has been determined to have at least a one point reduction (e.g., a ?1 point reduction or a ?2 point reduction) in Ishak fibrosis stage after administration compared to a baseline Ishak fibrosis stage obtained from the patient prior to administration.

Abstract: Disclosed are network managed volumes that enable simplified and more efficient use of information technology assets by allocating physical disk drives as needed. A pool of storage can be defined and populated with physical disks that are accessible in a storage area network. Virtual volumes are created from the storage pool, with each virtual volume being separately allocable to a host device (e.g., client, application server, etc.). Thus, host devices that have been allocated these virtual volumes perceive ownership of the entire volume, without requiring a present allocation of physical storage space having the same characteristics, but with seamless introduction of physical resources as needed.

Abstract: A method of operation and an apparatus for radiation hardening a combinational logic circuit are presented. A section of logic that is to be radiation hardened is identified. An entire logic circuit or a portion of the logic circuit may be radiation hardened. Once the section of logic is identified, a Field Effect Transistor (FET) is duplicated so as to create a voter FET. The voter FET is coupled with an original node (or signal) and a duplicated node (or signal). If a radiation event strikes either the original node or the duplicated node, the voter FET will prevent an upset from propagating to down stream logic by preventing a conduction path through the voter FET. Additionally, all of the circuitry that was duplicated in order to create the duplicated node may also undergo a radiation event without causing an upset to propagate to downstream logic.

Abstract: A new non-invasive, non-toxic, non-sedating method for treatment migraine, tension and post-traumatic headache, atypical facial pain, and cervical muscle hyperactivity (spasm) is presented. This method comprises the application of cold, through the use of a portable thermoelectric cooler, to an intra-oral area of tenderness which has been found to be associated with the above conditions. New portable thermoelectric cooler devices for use with the intended treatment methods are also presented. In one embodiment, the thermoelectric cooling units are directly housed in the U-shaped mouthpiece. In another embodiment, water is chilled thermoelectrically in a container and circulated through the U-shaped mouthpiece. Alleviation of pain is noted within a short period of the onset of the treatment. Repeated treatment even during pain-free periods offers protracted benefits, i.e., prevention or amelioration of the headaches or other conditions.

Abstract: A composition and its use for local percutaneous delivery of a drug, in particular a muscle relaxant, more particularly cyclobenzaprine present in an amount of about 1 to about 10% by weight of the composition in an organogel cream are disclosed. The composition is applied directly to the skin over accessible muscles of mastication from which it is rapidly absorbed through the skin to provide control of conditions such as bruxism and tooth clenching. The composition can also be applied to the skin overlying these muscles to control muscle hyperactivity (spasm) and/or trigger points, from other causes. The composition can be formulated to include another active agent such as a non-steroidal anti-inflammatory, for example ketoprofen.

Abstract: A powered wheeled carriage includes a patient support and a wheeled base. An auxiliary wheel mechanism includes an auxiliary wheel spring support for biasing an auxiliary wheel into contact with a floor. Operating a control apparatus moves the auxiliary wheel away from the floor. A drive handle pivots about a single axis to control a drive motor that powers the auxiliary wheel. The drive handle controls driving of the wheeled carriage in forward and rearward directions. A decision/drive circuit ramps the speed of the wheeled carriage for a few second after start-up to prevent a jerking motion. A display/control panel displays the condition of the carriage brake and the condition of the auxiliary wheel to assist an operator.

Abstract: An improved and automated ASP-delivered loan workout system, inclusive of communication architecture and software method that assists a user in improving the dialogue and counseling sessions between user, borrower, and other involved parties, and which increases loan servicer efficiency while decreasing the time and expense necessary to process loss mitigation cases-including identification of an appropriate financial workout solution, via the use of logical decision tree-based interviews-increases the rate of identification of viable loss mitigation options, and selects and manages the best loss mitigation solution, all in real-time, and within investor and lender requirements, within loan guarantor and insurer conditions, and in compliance with rapidly changing industry standards and government rules.

Abstract: An exercise device in which removable weight may be provided in a housing of the device. Two rotatable handles may be provided in the housing, permitting various hand orientations during exercise. The removable weight may be received within and/or removed from a cavity of the device.

Abstract: The present invention is a penile prosthesis device and a non-surgical method of implantation of the device into a penis. The prosthesis device is designed to be an elastic mantle to be implanted directly into the corpus cavernous cavity. The prosthesis device contains an elongated tube plugged at both ends and fillable with a biocompatible liquid. The liquid may be prefilled or injected into a implanted prosthesis device to achieve the resilience and feel of the penis. The invention includes a balloon which is inserted into the corpus cavernous cavity and a pump is used to pressurize the cavity and achieve a cylindrical expansion of the form of the penis. The invention also includes an elastic mantle having a unit including a plurality of magnets to achieve rigidity, thereby causing the penis to become erect.

Abstract: An exercise device, method of making the device and a method and system for interaction with an exercise device, in which removable, variable weight may be provided in a housing of the device. Two rotatable handles may be provided in the housing, permitting various hand orientations during exercise. The removable weight may be provided near the center of the exercise device, with the handles substantially outboard the weight. Weight may thus be efficiently added or removed in a central area of the housing between the handles.

Abstract: A dishwashing glove includes a sponge material secured to the palm region of the glove and an abrasive material secured to the upper ends of the fingers of the glove.

Abstract: A power assisted wheeled carriage includes a patient support having a length, a wheeled base supporting the patient support, and an auxiliary wheel mechanism including an auxiliary wheel spring support for biasing an auxiliary wheel into contact with a floor. The carriage further includes a control apparatus for moving the auxiliary wheel away from the floor. The auxiliary wheel spring support can be a spring steel member having an opening and biased to move the auxiliary wheel into contact with the floor. The control apparatus can include a foot pedal for turning a rotatable shaft that enables a cam apparatus to apply an upward force to the auxiliary wheel. The wheeled carriage also includes a drive handle pivotable about a single axis to control a drive motor for the auxiliary wheel. The drive handle controls driving of the wheeled carriage in forward and rearward directions. Safety sensors on the drive handle require grasping thereof at a specific location to operate the carriage.

Abstract: A dental handpiece having a filter unit containing a filter that minimizes the exposure of patients to pathogens found in the dental unit water lines (DUWL) while promoting frequent replacement of DUWL filters, by providing a disposable microfiltration filter that is easily replaced at low cost. A disk or membrane type filter is placed in a disconnectable autoclavable filter unit in the handle of an existing design dental instrument such that the form and function of the dental instrument are not adversely affected. The components of the handpiece, including the filter unit, are autoclavable, making the handpiece with its filter unit both economical to produce and ideal for its intended use.

Abstract: A power assisted wheeled carriage includes a patient support having a length, a wheeled base supporting the patient support, and an auxiliary wheel mechanism including an auxiliary wheel spring support for biasing an auxiliary wheel into contact with a floor. The carriage further includes a control apparatus for moving the auxiliary wheel away from the floor. The auxiliary wheel spring support can be a spring steel member having an opening and biased to move the auxiliary wheel into contact with the floor. The control apparatus can include a foot pedal for turning a rotatable shaft that enables a cam apparatus to apply an upward force to the auxiliary wheel. The wheeled carriage also includes a drive handle pivotable about a single axis to control a drive motor for the auxiliary wheel. The drive handle controls driving of the wheeled carriage in forward and rearward directions.