Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: A method for manufacturing a plastic speaker grill is provided. The method includes the steps of providing a base member having a first side and an opposing second side and defining a thickness therebetween. The base member has a plurality of spaced blind holes wherein the first side is in communication with the plurality of blind holes and the second side defines a surface that is generally uniform and uninterrupted. The method further includes cutting the base member proximate the second side to remove a portion of the base member and define the speaker grill, and in response to cutting the base member, exposing the blind holes wherein the blind holes define apertures that extend completely through the speaker grill. A plastic speaker grill is provided having tightly-spaced and miniscule apertures.

Abstract: A call setup and restoration schema is disclosed for providing an improved priority-based call setup and restoration schema in an optical communications system, allowing higher priority connections access to bandwidth by user-definable parameters. The call setup and restoration schema includes allowing higher priority connections to claim the resources of lower priority connections, and restoring them when bandwidth is available, or bumping another, even lower priority, connections. This aids in providing access to bandwidth by high priority services and in preventing outages or connection delays for high priority connections.

Abstract: An optical amplifier arrangement comprises a splitter for providing an input WDM optical signal on at least first and second output paths. An optical amplifier is provided in at least one of the paths, and a signal routing arrangement is provided for routing individual channels or groups of channels of the WDM signal within the at least one of the paths. A switch selects the signal from one of the at least first and second output paths. In this arrangement, there are two paths between the input and output. Whilst one path is being used, the components in the other path can be upgraded. For example, a switching arrangement may be provided in the other path, and an amplifier may also be upgraded, without disrupting service in the path in use. This enables an amplifying node within an optical communications system to be incrementally upgraded.

Abstract: The saturation effects observed in an MQW electro-absorption modulator are reduced by modifying the composition of the MQW structure so that the barrier layers, that are interleaved with the quantum well layers, are in tension.

Abstract: A method and system for enhancing the performance of feedforward amplifiers includes the provision of multiple sweep displays, one each for providing a display of a single performance characteristic of the amplifier. Various characteristics are monitored on an alternating and interleaved basis, and displayed during the intervals that they are monitored. The monitoring intervals are short enough so that each display appears to be continuous. The performance characteristics of the amplifier are thus observable on a real time basis, thereby facilitating adjustment of the amplifier to achieve optimum overall operation.