Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: A computing device and method for preparing application data based on a migration recommendation includes collecting survey responses to categorized questions and assigning a score to each of the survey response. The scored survey responses are normalized and rationalization parameters are determined based on the normalized scores. Application data are prepared for migration based on a recommended disposition determined from the rationalization parameters.

Abstract: The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, or a tautomer thereof, or a hydrate thereof.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: The present invention is directed to, in part, deuterium-enriched compounds and compositions comprising a deuterium-enriched compound useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: An image processing method for harmonizing images acquired by a first camera and a second camera connected to a vehicle and arranged in such a way as their fields of view cover a same road space at different times as the vehicle travels along a travel direction is disclosed. The method includes: acquiring by a selected camera, a first image at a first time; selecting a first region of interest bounding a road portion from the first image; sampling the first region of interest; acquiring by the other camera, a second image in such a way that the road portion is included in a second region of interest; sampling the second region of interest; and determining one or more correction parameters for harmonizing images acquired by the first and second cameras, based on a comparison between the image content of the first and second regions of interest.

Abstract: An endoscope system including a first reusable hand-piece and a second reusable hand-piece. The first reusable hand-piece is a different size than the second reusable hand-piece. The first reusable hand-piece and the second reusable hand-piece are selectively attachable and detachable to the same or a different single-use shaft assembly. Varying sizes of reusable hand-piece assemblies provide for improved user ergonomics. Ergonomic variations may include different size reusable hand-piece assemblies, different size articulation control knobs, and/or different distances between the centerline of the housing of the reusable hand-piece and the knobs and/or between the backstrap of the reusable hand-piece and the knobs, customizable to user preference.

Abstract: The present invention is directed to, in part, compositions or dosage forms comprising fused heteroaryl compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, neuromuscular disorders, trigeminal autonomic cephalalgia (TAC), migraine, cranial neuropathy or multiple cranial neuropathy, and cortical spreading depression (CSD) are also provided herein. In another aspect, the present invention provides a method of making ion channel modulators.

Abstract: A road embedded battery includes a first encapsulation layer disposed on top of a road grade base. A first conductor mesh is disposed on top of the first encapsulation layer and an anode material is embedded into to first conductor mesh. A permeable membrane is disposed on top of the anode material. A second conductor mesh is disposed on top of the permeable membrane and a cathode material is embedded into the second conductor mesh. A second encapsulation layer is disposed on top of the cathode material.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Abstract: Endoscope assemblies, systems, and methods of manufacturing same are disclosed. In particular, endoscopes having controls and/or tool port openings one end of an elongate handle and the insertion tube assembly and umbilical extending to the console at another end of the elongate handle are provided. Fluid control and flow path arrangements in the handle of the endoscope are also described as well as configurations for articulation links and constructions for insertion tubes.

Abstract: Arrangements comprising an endoscope system having an endoscope including a reusable hand-piece, a separable single-use shaft assembly, a single-use cartridge and a console are disclosed. Endoscope assemblies having articulation knobs attached by friction fit, multi-stage rotational distance limiters, and/or elevators are disclosed. Components of same, packaging systems, and methods are also provided.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. The fused heteroaryl compounds of the disclosure are represented by Formula (I): wherein X, Y, Z, A, R1 and R2 are as defined in the specification. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds of Formula (II-II): and compositions thereof, useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.