Patents by Inventor Mark A. Guelta

Mark A. Guelta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant OPAA enzymes with increased catalytic efficiency on cyclosarin
    Patent number: 10538749
    Abstract: The invention comprises isolated, mutant, non-wild-type organophosphorus acid anhydrolase (OPAA) enzymes having two site mutations, methods of production, and methods of use to effectively degrade cylcosarin (GF) (cyclohexyl methylphosphonofluoridate) with greater catalytic efficiency than the wild-type OPAA.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 21, 2020
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P Harvey, Melissa M Dixon, Mark A Guelta
  • Mutant organophosphorus acid anhydrolase enzymes having increased catalytic efficiency on V-agents
    Patent number: 10421952
    Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolases (OPPAs) having three or more site mutations, methods of production, kits and methods of use to effectively degrade toxic V-agent type chemical compounds such as VX, VR, CVX, and VM.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: September 24, 2019
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P Harvey, Mark A Guelta
  • Mutant OPAA enzyme with increased catalytic efficiency on GP
    Patent number: 10363289
    Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2, 2?-dimethylcyclopentyl methylphosphonofluoridate).
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: July 30, 2019
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P. Harvey, Mark A Guelta, Leslie R McMahon
  • Mutant OPAA enzyme with increased catalytic efficiency on organophosphorus compound GP
    Patent number: 10335465
    Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2?-dimethylcyclopentyl methylphosphonofluoridate).
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: July 2, 2019
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P Harvey, Melissa M Dixon, Mark A Guelta, Leslie R McMahon
  • Mutant organophosphorus acid anhydrolases and uses thereof
    Patent number: 10238904
    Abstract: Disclosed herein are non-wild-type organophosphorus acid anhydrolases having two site mutations, methods of production, and methods of use to effectively degrade toxic chemicals such as ((RS)-Propan-2-yl methylphosphonofluoridate) (Sarin) and other organophosphorus compounds.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: March 26, 2019
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Mark A Guelta, Melissa M. Dixon, Steven P Harvey
  • Mutant organophosphorus acid anhydrolase enzymes with stereospecificity on Sarin enantiomers and uses thereof
    Patent number: 10143874
    Abstract: Disclosed herein are non-wild-type organophosphorus acid anhydrolases having three site mutations, methods of production, and methods of use to effectively degrade toxic chemicals such as((RS)-Propan-2-yl methylphosphonofluoridate)(Sarin) and other organophosphorus compounds.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: December 4, 2018
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Sue Y Bae, Mark A. Guelta, Steven P Harvey
  • Mutant OPAA enzymes with increased catalytic efficiency on organophosphorus compound EA1356
    Patent number: 10124043
    Abstract: The invention comprises isolated, mutant, non-wild-type organophosphorus acid anhydrolase (OPAA) enzymes having three site mutations, methods of production, and methods of use to effectively degrade organophosphorus compound EA1356 (2-methylcyclohexyl methylphosphonofluoridate) with greater catalytic efficiency than the wild-type OPAA enzyme.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: November 13, 2018
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P Harvey, Mark A Guelta, Leslie R McMahon
  • OPAA FL—a mutant enzyme with increased catalytic efficiency on organophosphorus compound GD
    Patent number: 9976130
    Abstract: This invention is directed toward a non-wild-type organophosphorus acid anhydrolase enzyme having two site mutations, method of production, and method of use to more effectively degrade toxic organophosphorus compounds and, in particular, toxic chemical GD (3,3-Dimethylbutan-2-ylmethylphosphonofluoridate), than the wild type organophosphorus acid anhydrolase.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: May 22, 2018
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Mark A Guelta, Melissa M. Dixon, Steven P. Harvey
  • Mutated organophosphorus acid anhydrolases and their uses thereof
    Patent number: 9617526
    Abstract: The invention is directed toward non-wild-type organophosphorus acid anhydrolases having three site mutations, method of production, and method of use to effectively degrade toxic chemical compounds such as (Ethyl({2-[bis(propan-2-yl)amino]ethyl}sulfanyl)(methyl)phosphinate (“VX”).
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: April 11, 2017
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Steven P. Harvey, Mark A. Guelta
  • Mutated organophosphorus acid anhydrolases and their uses thereof
    Patent number: 9587232
    Abstract: The invention is directed toward non-wild-type organophosphorus acid anhydrolases having three site mutations, method of production, and method of use to effectively degrade toxic chemicals such as N,N-diethyl-2-(methyl-(2-methylpropoxy)phosphoryl)sulfanylethanamine) (“VR”).
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: March 7, 2017
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P. Harvey, Mark A. Guelta
  • Non-wild-type organophosphorus acid anhydrolases for enzymatic decontamination
    Patent number: 9017982
    Abstract: Provided are non-wild-type organophosphorus acid anhydrolases that are capable of degrading (ethyl {2-[bis(propan-2-yl)amino]ethyl}sulfanyl) (methyl)phosphinate and other V-agents. Particular embodiments include an organophosphorus acid anhydrolase including an amino acid substitution at position 212.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: April 28, 2015
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Saumil S. Shah, Mark A. Guelta, Steven P. Harvey
  • Method for measuring and testing the efficiency of gas mask filters using monodispersed aerosols
    Patent number: 5094779
    Abstract: An improved method of testing a particulate filter. This is accomplished by assing a salt nuclei coated with isopropyl isostearate.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: March 10, 1992
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Hugh R. Carlon, Mark A. Guelta, Bernard V. Gerber
  • Method of measuring the efficiency of gas mask filters using non-toxic mono dispersed aerosols
    Patent number: 5087389
    Abstract: An improved process of passing an aerosol mixture through a filter. The asol mixture solely contains in percentage, by volume, of about:______________________________________ % Chemical ______________________________________ A. 60-66 isostearic acid B. 13-17 isooleic acid C. 1-3 isopalmitic acid D. 8-10 stearic acid E. 6-12 oleic acid.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: February 11, 1992
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Hugh R. Carlon, Mark A. Guelta, Bernard V. Gerber
  • Method of measuring the efficiency of gas mask filters, respirators and other personnel protective equipment
    Patent number: 5080829
    Abstract: An improved method of testing a particulate filter. This is accomplished by assing a salt nuclei coated with a mixture containing isostearic acid, isopalmatic acid, myristic acid and palmitic acid through the filter to be tested.
    Type: Grant
    Filed: December 7, 1990
    Date of Patent: January 14, 1992
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Hugh R. Carlon, Mark A. Guelta, Bernard V. Gerber
  • Method of generating mono dispersed aerosols for non-destructive gas mask filter testing
    Patent number: 5076965
    Abstract: An improved process of passing an aerosol mixture through a filter. The asol is generated by nebulization of the mixture prior to penetration of the filter. The aerosol mixture solely being a poly-olefin having a content of chain hydrocarbon in %, by volume, of about:______________________________________ % Carbon chain length ______________________________________ 0.6 20 82.1 30 16.0 40 1.0 50 2.0 60.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: December 31, 1991
    Assignee: The United States of America as represented by the Secretatry of the Army
    Inventors: Mark A. Guelta, Hugh R. Carlon
  • Method for testing the efficiency of gas mask filters using monodispersed aerosols
    Patent number: 5059353
    Abstract: An improved process of passing an aerosol mixture through a filter. The aerosol mixture solely containing the following in percentage, by volume, of about:______________________________________ % Chemical ______________________________________ 71 oleic acid 8 palmitoleic acid 7 linoleic acid 4 palmitic acid 3 myristic acid 3 myristoleic acid 1.5 linolenic acid 1.5 margaric acid 1 stearic acid.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: October 22, 1991
    Assignee: The United States of America as representated by the Secretary of the Army
    Inventors: Hugh R. Carlon, Mark A. Guelta, Bernard V. Gerber
  • Method for the generation of monodispersed aerosols for filter testing
    Patent number: 5059352
    Abstract: An improved method of testing a particulate filter. This is accomplished by assing a salt nucleus coated with a composition containing a poly-alpha olefin having chain length in %, by volume, of about 97-99% of 20 carbon atoms, and about 3% of 30 carbon atoms.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: October 22, 1991
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Hugh R. Carlon, Mark A. Guelta, Bernard V. Gerber
  • Method of measuring the efficiency of gas mask filters using monodispersed aerosols
    Patent number: 5059349
    Abstract: An improved process of passing an aerosol mixture through a filter. The asol mixture solely being a poly-alpha olefin having a content of chain lengths in % by volume of about:______________________________________ % Carbon atoms, chain length ______________________________________ 0.6 20 82.1 30 16.0 40 1.0 50 2.0 60.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: October 22, 1991
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Hugh R. Carlon, Mark A. Guelta, Bernard V. Gerber
  • Method of testing the efficiency of gas mask filters using monodispersed aerosols
    Patent number: 5059351
    Abstract: An improved method of testing a particulate filter. This is accomplished by assing the following ester mixture on salt nuclei consisting essentially in percentage, by volume, of about:______________________________________ % Chemical ______________________________________ 58 methyl oleate 24 methyl stearate 14 methyl linoleate 4 methyl palmitate.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: October 22, 1991
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Hugh R. Carlon, Mark A. Guelta, Bernard V. Gerber
  • Method for measuring filter efficiency
    Patent number: H1040
    Abstract: An improved process of passing an aerosol mixture through a filter. The asol mixture solely contains about 70 to 76% isostearic acid, about 6 to 7% isopalmatic acid, about 7 to 11% myristic acid, and about 4 to 5% palmitic acid.
    Type: Grant
    Filed: December 7, 1990
    Date of Patent: April 7, 1992
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Hugh R. Carlon, Mark A. Guelta, Bernard V. Gerber