Patents by Inventor Mark A. Hadd

Mark A. Hadd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PDE 7 MODULATOR COMPOUNDS
    Publication number: 20250066383
    Abstract: Compounds having activity as modulators of phosphodiesterase 7 (PDE 7) are provided. The compounds have the following Structures (I) or (II): as a stereoisomer, enantiomer, or tautomer thereof or a mixture thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein each of R1, R2, R3, R4a, R4b, ring A, ring B, ring A? and ring B? (i.e., {circle around (A)}, {circle around (B)}, , and as shown in Structure (I) and (II), respectively) are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of phosphodiesterase 7 (PDE 7) are also provided.
    Type: Application
    Filed: August 21, 2024
    Publication date: February 27, 2025
    Inventors: Neil S. CUTSHALL, Mark A. HADD, Santosh Kumar KESHIPEDDY, Robert H. LEMUS, Markus METZ
  • Process for the preparation of halo-4-phenoxyquinolines
    Patent number: 5973153
    Abstract: The present invention relates to a new improved, simplified process for the preparation of halo-4-phenoxyquinolines, whereby thionyl chloride is used as the chlorinating agent to prepare the corresponding chloroquinoline intermediate prior to the final coupling reaction, and a single, inert high boiling polyether solvent is used throughout the entire reaction procedure.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: October 26, 1999
    Inventors: Tim J. Adaway, Jeff T. Budd, Ian R. King, Karl L. Krumel, Larry D. Kershner, Julie L. Maurer, Thomas A. Olmstead, Gary A. Roth, Jimmy J. Tai, Mark A. Hadd