Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating efficient compiled code. In an example method, a compilation system obtains an un-optimized computational graph comprising a plurality of nodes representing operations and directed edges representing data dependencies. The un-optimized computational graph is analyzed using pattern matching to determine fusable operations that can be fused together into a single fusion operation. The un-optimized computational graph is transformed into an optimized computational graph by replacing the nodes representing the fusable operations in the un-optimized computational graph with a fusion node representing the single fusion operation. The compilation system produces efficient code by translating the fusion node of the optimized computational graph as a call that performs the fused operations.

Abstract: Systems and methods for accessing locally-stored content for a web application are disclosed. In some aspects, a user input for requesting a web application is received at a client computing device. A network request for the web application is provided via a network. That software code for the web application is stored in local storage of the client computing device is determined. The stored software code for the web application is placed into a random access memory (RAM) of the client computing device. At least a portion of the stored software code is precompiled prior to receiving a response to the network request.

Abstract: Systems and methods for accessing locally-stored content for a web application are disclosed. In some aspects, a user input for requesting a web application is received at a client computing device. A network request for the web application is provided via a network. That software code for the web application is stored in local storage of the client computing device is determined. The stored software code for the web application is placed into a random access memory (RAM) of the client computing device. At least a portion of the stored software code is precompiled prior to receiving a response to the network request.

Abstract: The present invention provides compounds and methods for the treatment and prophylaxis of renal disease and inflammation. In particular the invention provides methods for the treatment of kidney disease and failure through the administration of compounds which function as inhibitors of TLR2 function and expression.

Abstract: Systems and methods for delivering an update for a web application are provided. In some aspects, a request to access a web application is received from a client computing device. A last version of the web application provided to a computing device having an identifier associated with the client computing device is determined based on data stored locally at a server. A delta file is provided to the client computing device in response to the request to access the web application. The delta file includes indicia of a difference between a current version of the web application stored at the server and the last version of the web application provided to the computing device having the identifier associated with the client computing device.

Abstract: Systems and methods for accessing locally-stored content for a web application are disclosed. In some aspects, a user input for requesting a web application is received at a client computing device. A network request for the web application is provided via a network. That software code for the web application is stored in local storage of the client computing device is determined. The stored software code for the web application is placed into a random access memory (RAM) of the client computing device. At least a portion of the stored software code is precompiled prior to receiving a response to the network request.

Abstract: Techniques for advertising are provided. A mobile device is synchronized with a media feed playing on a separate device and metadata for products and services related to the media feed are presented on the mobile device. A user makes comments on selective products and services and actions are performed on the mobile device to assist the user in one or more of: acquiring additional information for the selected products and services, scheduling a time to try out the selected products and services, and purchasing and/or picking up the selected products and services.

Abstract: The present invention provides compounds and methods for the treatment and prophylaxis of ischemia reperfusion injury. In particular the invention provides compounds which function to suppress Toll-like Receptor 2 biological function or expression.

Abstract: Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.

Abstract: The present invention provides compositions and methods for the treatment of autoimmune diseases, in particular rheumatoid arthritis. Compounds which function as antagonists of Toll-like Receptor 2 are shown to suppress the immune response which result in the onset and progression of autoimmune disease. In particular monoclonal antibodies which have a binding specificity to Toll-like receptor 2 are disclosed for use in methods for the treatment and/or prophylaxis of autoimmune disease.

Abstract: Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.

Abstract: The present invention provides compounds and methods for the treatment and prophylaxis of renal disease and inflammation. In particular the invention provides methods for the treatment of kidney disease and failure through the administration of compounds which function as inhibitors of TLR2 function and expression.

Abstract: The present invention provides compounds and methods for the treatment and prophylaxis of ischemia reperfusion injury. In particular the invention provides compounds which function to suppress Toll-like Receptor 2 biological function or expression.

Abstract: The present invention provides compounds and methods for the treatment and prophylaxis of ischemia reperfusion injury. In particular the invention provides compounds which function to suppress Toll-like Receptor 2 biological function or expression.

Abstract: Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.

Abstract: The present invention provides compounds and methods for the treatment and prophylaxis of renal disease and inflammation. In particular the invention provides methods for the treatment of kidney disease and failure through the administration of compounds which function as inhibitors of TLR2 function and expression.

Abstract: The present invention provides compositions and methods for the treatment of autoimmune diseases, in particular rheumatoid arthritis. Compounds which function as antagonists of Toll-like Receptor 2 are shown to suppress the immune response which result in the onset and progression of autoimmune disease. In particular monoclonal antibodies which have a binding specificity to Toll-like receptor 2 are disclosed for use in methods for the treatment and/or prophylaxis of autoimmune disease.

Abstract: The present invention relates to the identification of an epitope defined by residues of Toll-like Receptor (2). Targeting a binding compound, such as an antibody to the epitope results in antagonism of Toll-like Receptor (2). Further provided by the invention is the use of polypeptide comprising amino acid residues which form the epitope for use in screening for binding compounds which bind thereto, as well as to polypeptide compound which comprise the amino acid sequences of the epitope for use as vaccine compositions, when the generation of antagonistic antibodies which have binding specificity to Toll-like Receptor (2) are required, for example in the treatment of Toll-like Receptor (2) mediated disease conditions.

Abstract: Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.