Patents by Inventor Mark A. Hoon
Mark A. Hoon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11324725Abstract: Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.Type: GrantFiled: November 2, 2018Date of Patent: May 10, 2022Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Mark A. Hoon, Hans Juergen Solinski, James Inglese, Patricia Dranchak
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Publication number: 20210145800Abstract: Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.Type: ApplicationFiled: November 2, 2018Publication date: May 20, 2021Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Mark A. Hoon, Hans Juergen Solinski, James Inglese, Patricia Dranchak
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Patent number: 10583173Abstract: Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.Type: GrantFiled: May 4, 2018Date of Patent: March 10, 2020Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Mark A. Hoon, Santosh K. Mishra
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Publication number: 20190135804Abstract: Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.Type: ApplicationFiled: May 14, 2018Publication date: May 9, 2019Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Mark A. Hoon, Hans Juergen Solinski, James Inglese, Patricia Dranchak
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Publication number: 20180318396Abstract: Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Applicant: The United States of America, as represented by the Secretary, Department of Health and HumanInventors: Mark A. Hoon, Santosh K. Mishra
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Patent number: 9987330Abstract: Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.Type: GrantFiled: December 4, 2014Date of Patent: June 5, 2018Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Mark A. Hoon, Santosh K. Mishra
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Publication number: 20170014486Abstract: Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.Type: ApplicationFiled: December 4, 2014Publication date: January 19, 2017Applicant: The united States of America, as represented by the Secretary , Department of Health & Human ServiInventors: Mark A. HOON, Santosh K. MISHRA
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Patent number: 9347935Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.Type: GrantFiled: May 28, 2013Date of Patent: May 24, 2016Assignees: The Regents of the University of California, The United States of America as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
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Publication number: 20140024043Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.Type: ApplicationFiled: May 28, 2013Publication date: January 23, 2014Applicant: The Regents of the University of CaliforniaInventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
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Patent number: 8470970Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.Type: GrantFiled: November 11, 2010Date of Patent: June 25, 2013Assignees: The Regents of the University of California, The Government of the United States of AmericaInventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
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Patent number: 8198048Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: GrantFiled: March 10, 2010Date of Patent: June 12, 2012Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human ServicesInventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
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Publication number: 20110244514Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: ApplicationFiled: March 10, 2010Publication date: October 6, 2011Inventors: Charles S. Zuker, Nicholas J.P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
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Patent number: 7977060Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: GrantFiled: June 26, 2008Date of Patent: July 12, 2011Assignees: Regents of the University of California, The United States of America as represented by NIHInventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
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Publication number: 20110151483Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.Type: ApplicationFiled: November 11, 2010Publication date: June 23, 2011Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
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Publication number: 20090098580Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: ApplicationFiled: June 26, 2008Publication date: April 16, 2009Inventors: Charles S. Zuker, Nicholas J.P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
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Patent number: 7507793Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: GrantFiled: August 20, 2003Date of Patent: March 24, 2009Assignees: The Regents of the University of California, United States of America Dept. of Health and Human Services National Institutes of Health-OTTInventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
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Publication number: 20080318251Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.Type: ApplicationFiled: May 15, 2008Publication date: December 25, 2008Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J.P. Ryba, Mark A. Hoon
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Patent number: 7402400Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: GrantFiled: August 10, 2001Date of Patent: July 22, 2008Assignees: Regents of the University of California, The United States of America Department of Health and Human ServicesInventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
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Publication number: 20030166137Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.Type: ApplicationFiled: July 3, 2002Publication date: September 4, 2003Applicant: The Regents of the University of CaliforniaInventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J.P. Ryba, Mark A. Hoon
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Publication number: 20030040045Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: ApplicationFiled: August 10, 2001Publication date: February 27, 2003Applicant: The Regents of the University of CaliforniaInventors: Charles S. Zuker, Gregory A. Nelson, Jayaram Chandrashekar, Yifeng Zhang, Nicholas J.P. Ryba, Mark A. Hoon
