Patents by Inventor Mark A. Hoon

Mark A. Hoon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for the inhibition of pruritus
    Patent number: 11324725
    Abstract: Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: May 10, 2022
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Mark A. Hoon, Hans Juergen Solinski, James Inglese, Patricia Dranchak
  • COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS
    Publication number: 20210145800
    Abstract: Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.
    Type: Application
    Filed: November 2, 2018
    Publication date: May 20, 2021
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Mark A. Hoon, Hans Juergen Solinski, James Inglese, Patricia Dranchak
  • Methods of treating or preventing pruritis by blocking natriuretic polypeptide b
    Patent number: 10583173
    Abstract: Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: March 10, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Mark A. Hoon, Santosh K. Mishra
  • COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS
    Publication number: 20190135804
    Abstract: Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.
    Type: Application
    Filed: May 14, 2018
    Publication date: May 9, 2019
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Mark A. Hoon, Hans Juergen Solinski, James Inglese, Patricia Dranchak
  • METHODS OF TREATING OR PREVENTING PRURITIS BY BLOCKING NATRIURETIC POLYPEPTIDE B
    Publication number: 20180318396
    Abstract: Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.
    Type: Application
    Filed: May 4, 2018
    Publication date: November 8, 2018
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human
    Inventors: Mark A. Hoon, Santosh K. Mishra
  • Methods of treating or preventing pruritis by blocking natriuretic polypeptide B
    Patent number: 9987330
    Abstract: Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: June 5, 2018
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Mark A. Hoon, Santosh K. Mishra
  • METHOD FOR IDENTIFYING COMPOUNDS THAT MODULATE A T2R TASTE RECEPTOR
    Publication number: 20180128842
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Application
    Filed: October 17, 2017
    Publication date: May 10, 2018
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Method for identifying compounds that modulate a T2R taste receptor
    Patent number: 9817000
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: November 14, 2017
    Assignee: The Regents of the University of California
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • METHODS OF TREATING OR PREVENTING PRURITIS BY BLOCKING NATRIURETIC POLYPEPTIDE B
    Publication number: 20170014486
    Abstract: Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.
    Type: Application
    Filed: December 4, 2014
    Publication date: January 19, 2017
    Applicant: The united States of America, as represented by the Secretary , Department of Health & Human Servi
    Inventors: Mark A. HOON, Santosh K. MISHRA
  • Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1
    Patent number: 9347935
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: May 24, 2016
    Assignees: The Regents of the University of California, The United States of America as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
  • METHOD FOR IDENTIFYING COMPOUNDS THAT MODULATE A T2R TASTE RECEPTOR
    Publication number: 20150260733
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Application
    Filed: May 19, 2015
    Publication date: September 17, 2015
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Method for identifying compounds that modulate a T2R taste receptor
    Patent number: 9063124
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: June 23, 2015
    Assignee: The Regents of the University of California
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • T2R, A NOVEL FAMILY OF TASTE RECEPTORS
    Publication number: 20140120553
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Application
    Filed: November 20, 2013
    Publication date: May 1, 2014
    Applicant: The Regents of the University of California
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Mammalian Sweet and Amino Acid Heterodimeric Taste Receptors Comprising T1R3 and T1R1
    Publication number: 20140024043
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: May 28, 2013
    Publication date: January 23, 2014
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
  • Nucleic acids encoding T2R bitter taste receptors
    Patent number: 8624012
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: January 7, 2014
    Assignee: The Regents of the University of California
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Methods for identifying compounds which modulate T2R bitter taste receptors
    Patent number: 8580527
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: November 12, 2013
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Mark Hoon, Nick Ryba, Ken Mueller
  • Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1
    Patent number: 8470970
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: June 25, 2013
    Assignees: The Regents of the University of California, The Government of the United States of America
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
  • Nucleic acid encoding a T2R taste receptor
    Patent number: 8329885
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: December 11, 2012
    Assignees: The Regents of the University of California, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Mammalian sweet taste receptors
    Patent number: 8198048
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: June 12, 2012
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • NUCLEIC ACIDS ENCODING T2R, A NOVEL FAMILY OF TASTE RECEPTORS
    Publication number: 20120135447
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Application
    Filed: October 11, 2011
    Publication date: May 31, 2012
    Applicants: The Govt. of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services, The Regents of the University of California
    Inventors: Charles S. Zuker, Jon Elliot Adler, Mark Hoon, Nick Ryba, Ken Mueller