Abstract: The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in decreasing glial tumor cell proliferation and treating glioma.

Abstract: The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in decreasing glial tumor cell proliferation and treating glioma.

Abstract: The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.

Abstract: The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.

Abstract: An apparatus and method for retarding an engine having a cylinder with an exhaust valve, an intake valve, an intake stroke, an exhaust stroke, a compression stroke and an expansion stroke. The apparatus includes an exhaust brake and a compression release brake. The exhaust brake includes a variable exhaust restrictor, a pressure sensor for sensing pressure of exhaust gases and a controller operatively connected to the pressure sensor and to the exhaust restrictor. Opening of the exhaust restrictor is adjusted during operation of the apparatus so exhaust pressure is sufficient to cause exhaust valve float prior to bottom dead center of intake strokes of the cylinder, thereby enhancing operation of the compression release brake.

Abstract: A variable valve actuation system for providing discrete exhaust and intake valve lift profiles for various operating modes of an internal combustion engine. The variable valve actuation system includes exhaust and intake rocker assemblies, exhaust and intake hydraulic extension devices operatively coupling corresponding rocker assemblies with respective engine valves and exhaust and intake control valves for selectively supplying the pressurized hydraulic fluid to the extension devices so as to independently switch them between a pressurized condition and a depressurized condition. The engine further includes an exhaust brake provided to initiate a small lift of the exhaust valve during the engine braking operation while the exhaust extension device maintains the exhaust valve open during a compression stroke for bleeder-compression release braking. The exhaust and intake valves can be adjusted independently to provide combinations of valve lift modes.

Abstract: A variable valve actuation system for providing discrete exhaust and intake valve lift profiles for various operating modes of an internal combustion engine. The variable valve actuation system includes exhaust and intake rocker assemblies, exhaust and intake hydraulic extension devices operatively coupling corresponding rocker assemblies with respective engine valves and exhaust and intake control valves for selectively supplying the pressurized hydraulic fluid to the extension devices so as to independently switch them between a pressurized condition and a depressurized condition. The engine further includes an exhaust brake provided to initiate a small lift of the exhaust valve during the engine braking operation while the exhaust extension device maintains the exhaust valve open during a compression stroke for bleeder-compression release braking. The exhaust and intake valves can be adjusted independently to provide combinations of valve lift modes.

Abstract: A controlled exhaust brake for an engine comprises an exhaust restrictor located in an exhaust system downstream of an exhaust manifold of an engine. An actuator operably associated with the restrictor adjusts the restrictor. A pressure sensor operably associated with the exhaust manifold senses pressure in the exhaust manifold. A controller determines a set pressure in the exhaust manifold correlated with speed of the engine. The controller is in communication with the pressure sensor and the actuator, and causes adjustment of the restrictor in order to achieve and maintain the set pressure in the exhaust manifold.

Abstract: A compression release engine brake apparatus and method for an internal combustion engine includes an exhaust gas recirculator that is connectable between the exhaust outlet and the intake manifold of the engine. The exhaust gas recirculator is operative during operation of the engine brake apparatus to recirculate at least a portion of exhaust gases from the exhaust outlet to the intake manifold to increase charging of the cylinders of the engine prior to the compression stroke. Preferably there is an exhaust restrictor downstream of the exhaust outlet. The engine preferably includes a turbocharger downstream of the exhaust outlet. The exhaust restrictor may be a restrictive turbocharger. Preferably there is an exhaust gas cooler connectable between the exhaust outlet and the intake manifold. This process optimizes engine brake performance and is an effective control for exhaust pressure and temperature and for turbocharger speed.

Abstract: The present invention provides a hydraulic actuator for operating an engine valve, which includes a means for controlling the seating velocity of the valve. The design allows for free, unrestricted movement of the actuator piston during opening of the engine valve, and an unrestricted return of the piston and valve until the valve is within a predetermined distance of the valve seat. Once within this predetermined range, the return velocity of the actuator piston and engine valve are limited by the rate at which a fluid may escape through a restriction. The restriction is calibrated to provide the desired maximum valve seating velocity. The invention also provides for automatic lash adjustment.

Abstract: A controlled exhaust brake for an engine comprises an exhaust restrictor located in an exhaust system downstream of an exhaust manifold of an engine. An actuator operably associated with the restrictor adjusts the restrictor. A pressure sensor operably associated with the exhaust manifold senses pressure in the exhaust manifold. A controller determines a set pressure in the exhaust manifold correlated with speed of the engine. The controller is in communication with the pressure sensor and the actuator, and causes adjustment of the restrictor in order to achieve and maintain the set pressure in the exhaust manifold.

Abstract: The present invention provides a hydraulic actuator for operating an engine valve, which includes a means for controlling the seating velocity of the valve. The design allows for free, unrestricted movement of the actuator piston during opening of the engine valve, and an unrestricted return of the piston and valve until the valve is within a predetermined distance of the valve seat. Once within this predetermined range, the return velocity of the actuator piston and engine valve are limited by the rate at which a fluid may escape through a restriction. The restriction is calibrated to provide the desired maximum valve seating velocity. The invention also provides for automatic lash adjustment.

Abstract: The present invention provides a hydraulic actuator for operating an engine valve, which includes a means for controlling the seating velocity of the valve. The design allows for free, unrestricted movement of the actuator piston during opening of the engine valve, and an unrestricted return of the piston and valve until the valve is within a predetermined distance of the valve seat. Once within this predetermined range, the return velocity of the actuator piston and engine valve are limited by the rate at which a fluid may escape through a restriction. The restriction is calibrated to provide the desired maximum valve seating velocity. The invention also provides for automatic lash adjustment.

Abstract: A lost motion variable valve actuation system utilizing a single solenoid valve or trigger valve to vary the timing of the intake and exhaust valves for a cylinder of an internal combustion engine. The solenoid controls the oil supply to the tappets, which in turn, determine valve motion in response to a camshaft lobe The system allows independent control of each valve and provides for advanced features such as enhanced intake air swirl, two-valve or four-valve operation and staggered valve opening. The invention provides for valve operation even in the event of a total loss of system hydraulic pressure. The invention provides the practical benefits of a fully-variable system while preserving the security and reliability of a mechanical, cam-driven valve train. The invention provides for filling the exhaust and intake tappets independently without connecting their respective hydraulic circuits.

Abstract: An engine valve actuation system is disclosed, which is capable providing compression release engine braking in combination with exhaust gas recirculation while maintaining main exhaust and main intake valve events of constant magnitude during both positive power and engine braking. The system is also capable of providing a constant level of desired overlap between main exhaust and main intake valve events during both positive power and engine braking. The system may provide the foregoing functions by using first and second valve actuation subsystems to provide the full spectrum of exhaust valve motions. Both the first and second subsystems may receive an input motion from a valve train element. The first subsystem operates only when the engine braking system is enabled. The second subsystem operates both during positive power and during engine braking.

Abstract: In an internal combustion engine braking system which may provide compression release braking and/or exhaust braking, methods and systems are disclosed of controlling the overlap between an exhaust gas recirculation event and an intake valve event to optimize engine braking at various engine operating speeds. Optimization may be achieved by selectively advancing and retarding the opening and closing of an exhaust valve for exhaust gas recirculation. The opening and closing of the exhaust valve may be carried out responsive to the monitored levels of such engine parameters as: exhaust manifold pressure, exhaust manifold temperature, cylinder pressure, and/or cylinder temperature. Various engine parameters may be monitored. Control of exhaust gas recirculation may be responsive thereto, such that a monitored parameter does not exceed a predetermined level.

Abstract: A variably timed internal combustion engine valve actuation system and method for opening valves in internal combustion engines. The system functions during both positive power and engine braking, to control the amount of "lost motion" between a valve and a means for opening the valve. In particular, the invention relates to a lost motion engine valve actuation system using a dedicated cam for effecting exhaust valve openings for compression release braking and exhaust gas recirculation ("EGR").

Abstract: In its broadest terms, the invention provides methods for the enhanced intracellular delivery of therapeutically active molecules to a target tumor cell. In a preferred embodiment, the method comprises providing engineered cells that express a heterologous nucleic acid that encodes a connexin and that contain a pro-drug activating gene, and contacting target tumor cells in a solid tumor with engineered cells that form functional gap junctions with said target tumor cells, such that the therapeutic molecule passes through a gap junction to a target tumor cell.

Abstract: Apoptosis-promoting recombinant Id polypeptides comprise an Id N-terminus domainpeptides comprise an Id N-terminus domain peptide comprising an effective portion of the N-terminal domain of a natural Id protein. The polypeptides may be produced recombinantly from transformed host cells from the subject recombinant Id polypeptide encoding nucleic acids. The invention provides methods of making and using the subject compositions and mimic thereof to modulate cellular physiology, and especially promote apoptosis and in the biopharmaceutical industry.

Abstract: An internal combustion engine may include a hydraulic linkage used to transfer motion from a valve train element, such as a cam, to an engine valve. Method and apparatus for selectively limiting the motion transferred by the hydraulic linkage from the valve train element to the engine valve are disclosed. The hydraulic linkage may comprise means for resetting or clipping the displacement of the engine valves into the engine cylinder following a compression release event. The hydraulic linkage may also limit the displacement of the engine valves into the engine cylinder for main exhaust and/or other valve events, as well as limit the overlap between a main exhaust valve event and an intake valve event.