Abstract: The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.

Abstract: The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.

Abstract: Thermoplastic compositions useful for sealing longitudinal joints of substrates, for example, roadways and pavement, are provided herein. Formulations including the composition and methods of using the thermoplastic composition to seal longitudinal joints are also disclosed.

Abstract: A selective catalytic reduction (SCR) system for treating exhaust gas from a diesel engine is provided, along with a method of assembling such a system. The system comprises a frame, a SCR catalyst contained within a SCR canister, and an ammonia oxidation catalyst contained within an ammonia oxidation canister. Each of the SCR and ammonia oxidation canisters is removably attached to the frame.

Abstract: Thermoplastic compositions useful for sealing longitudinal joints of substrates, for example, roadways and pavement, are provided herein. Formulations including the composition and methods of using the thermoplastic composition to seal longitudinal joints are also disclosed.

Abstract: The disclosed computer-implemented method for protecting geolocation information may include (i) receiving, by a computing device, a geolocation security policy that defines an area in which access to geolocation information by applications will be at least partially limited to protect the privacy of a user, (ii) detecting, by the computing device, a geolocation of the computing device, (iii) applying, by the computing device, the geolocation security policy to the detected geolocation to determine whether the detected geolocation matches the area in which access to geolocation information by the applications will be at least partially limited, and (iv) performing, by the computing device, a security action to protect the privacy of the user based on determining that the detected geolocation matches the area. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Thermoplastic compositions useful for sealing longitudinal joints of substrates, for example, roadways and pavement, are provided herein. Formulations including the composition and methods of using the thermoplastic composition to seal longitudinal joints are also disclosed.

Abstract: A method for implementing adaptive policy based computer security is described. In one embodiment, the method may include monitoring a behavior of a user on a computing device associated with the user, determining whether the user triggers one or more policy triggers associated with a broad policy or at least one sub-policy of the broad policy, or both, and upon determining the user triggers at least one policy trigger during the monitoring period, implementing a customized version of the broad policy on the computing device. In some cases, the method may include implementing the broad policy on the computing device upon determining the user does not trigger any of the one or more policy triggers. In other cases, the method may include triggering at least one of the policy triggers based at least in part on a requested action and determining whether the requested action includes a security threat.

Abstract: The disclosed computer-implemented method for protecting a cloud storage against suspected malware may include (1) receiving a backup of one or more encrypted files over a network, (2) determining that the one or more encrypted files match one or more criteria associated with suspected malware, and (3) performing a security action that protects a computing device against the suspected malware. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A vehicular exterior mirror assembly includes a turn signal unit disposed at a mirror casing of the exterior mirror assembly. The turn signal unit includes a housing portion, at least one light source and a lens. With the exterior mirror assembly disposed at a side of an equipped vehicle, light emitted by the at least one light source, when the at least one light source is electrically powered, passes through the lens in the direction of forward travel of the equipped vehicle. With the exterior mirror assembly disposed at the side of the equipped vehicle, the turn signal unit (i) responsive to a charge level signal indicative of a vehicle charge level of a power source of the equipped vehicle, emits light to indicate the vehicle charge level, and (ii) responsive to actuation of a turn signal indicator of the equipped vehicle, emits light to provide a turn signal indication.

Abstract: An exterior rearview mirror assembly for a vehicle includes a turn signal unit having a housing, a light source and a lens disposed in front of the light source and attached at the housing. The turn signal unit includes an aperture element disposed between the light source and the lens, and includes a film disposed between the lens and the housing so as to be in front of the light source. With the exterior rearview mirror assembly disposed at a side of the vehicle, light emitted by the light source, when powered, passes through the film and through an aperture of the aperture element and through the lens in the forward direction of travel of the equipped vehicle. The film includes structured sections such that light emitted by the light source, when powered, passes through the structured sections of the film and forms an illuminated logo.

Abstract: A vehicular exterior mirror assembly includes a turn signal unit disposed at a mirror casing of the exterior mirror assembly. The turn signal unit includes a housing portion, at least one light source and a lens. With the exterior mirror assembly disposed at a side of an equipped vehicle, light emitted by the at least one light source, when the at least one light source is electrically powered, passes through the lens in the direction of forward travel of the equipped vehicle. With the exterior mirror assembly disposed at the side of the equipped vehicle, the turn signal unit (i) responsive to a charge level signal indicative of a vehicle charge level of a power source of the equipped vehicle, emits light to indicate the vehicle charge level, and (ii) responsive to actuation of a turn signal indicator of the equipped vehicle, emits light to provide a turn signal indication.

Abstract: A computer-implemented method for identifying malicious computer files may include (i) receiving, by a computing device, a set of files from a set of client devices, (ii) performing, by the computing device, a machine learning classification of file attributes on the set of files, (iii) determining, based on the machine learning classification, a node pattern of a suspicious file in the set of files, (iv) calculating, by hashing the node pattern, a file prevalence score of the suspicious file, and (v) performing, by the computing device, a security action based on the file prevalence score of the suspicious file. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A selective catalytic reduction (SCR) system for treating exhaust gas from a diesel engine is provided, along with a method of assembling such a system. The system comprises a frame, a SCR catalyst contained within a SCR canister, and an ammonia oxidation catalyst contained within an ammonia oxidation canister. Each of the SCR and ammonia oxidation canisters is removably attached to the frame.

Abstract: The disclosed computer-implemented method for classifying files as specific types of malware may include (i) identifying an unknown file on a computing device, (ii) performing an analysis of the unknown file by applying, to the unknown file, a machine-learning heuristic that employs at least one decision tree, (iii) classifying the unknown file as malicious based on the analysis, and (iv) after classifying the unknown file as malicious, using the same decision tree employed by the machine-learning heuristic to sub-classify the unknown file by (a) identifying at least one leaf node of the decision tree arrived at by the analysis performed by the machine-learning heuristic on the unknown file, (b) determining that the leaf node of the decision tree is associated with a particular type of malicious file, and (c) sub-classifying the unknown file as the particular type of malicious file. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Providing joint access to an isolated computer object by both an isolated computer application and a non-isolated computer application. In one embodiment, a method may include executing a first computer application as a virtualized first computer application in an isolation layer, executing a second computer application as an actual second computer application in an operating system outside the isolation layer, creating a virtualized second computer object in the isolation layer in a location accessible to the virtualized first computer application, creating a gateway third computer object associated with the virtualized second computer object, storing the gateway third computer object outside the isolation layer in a location accessible to the operating system, and enabling joint access to the gateway third computer object by both the virtualized first computer application and the actual second computer application.

Abstract: A method for anonymous reputation requests is described. In one embodiment, the method includes calculating a full thumbprint of an object on a client machine, trimming one or more bits from the full thumbprint to generate a trimmed thumbprint, sending the trimmed thumbprint to a reputation server, and receiving a result from the reputation server regarding the trimmed thumbprint.