Patents by Inventor Mark A. Labow

Mark A. Labow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interleukin-1 related gene and protein
    Patent number: 7374911
    Abstract: Disclosed in an interleukin-1 related gene and gene product. In particular, the invention relates to a protein that is highly homologous to known interleukin-1 cytokines, nucleic acid molecules that encode such a protein, antibodies that recognize the protein, and methods for diagnosing conditions related to host inflammatory and immune responses.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: May 20, 2008
    Inventors: Mark A. Labow, Vadim Iourgenko
  • Interleukin-1 Related Gene and Protein
    Publication number: 20080045699
    Abstract: Disclosed is an interleukin-1 related gene and gene product. In particular, the invention relates to a protein that is highly homologous to known interleukin-1 cytokines, nucleic acid molecules that encode such a protein, antibodies that recognize the protein, and methods for diagnosing conditions related to host inflammatory and immune responses.
    Type: Application
    Filed: July 12, 2007
    Publication date: February 21, 2008
    Inventors: Mark Labow, Vadim Iourgenko
  • Cyclic amp response element activator proteins and uses related thereto
    Publication number: 20070036810
    Abstract: The invention discloses newly identified cyclic AMP response element activator proteins (CREAP proteins). It is contemplated herein that said proteins are suitable drug targets for the development of new therapeutics to prevent, treat or ameliorate pathological conditions related to abnormal activation of CRE-dependent gene expression or abnormal activation of chemokines. The invention relates to methods to prevent, treat or ameliorate said pathological conditions and pharmaceutical compositions therefor comprising modulators with inhibitory effect on CREAP protein activity and/or CREAP gene expression. The invention also relates to methods to identify compounds with therapeutic usefulness to treat said pathological conditions, comprising identifying compounds that can inhibit CREAP protein activity and/or CREAP gene expression.
    Type: Application
    Filed: March 25, 2004
    Publication date: February 15, 2007
    Inventors: Vadim Iourgenko, Mark Labow, Chuanzheng Song, Wenjun Zhang, Jian Zhu
  • Mammary gland chemokine
    Patent number: 6833241
    Abstract: The present invention provides various methods for utilizing a polypeptide encoding a chemokine (MEC) and a polypeptide translated therefrom. The MEC chemokine is underexpressed in tumors, making the chemokine a useful marker for diagnosis and prognosis of adverse bodily reactions.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: December 21, 2004
    Assignee: Novartis
    Inventors: Mark A. Labow, Craig Stephen Mickanin, Umesh Bhatia
  • Interleukin-1 related gene and protein
    Publication number: 20040241807
    Abstract: Disclosed in an interleukin-1 related gene and gene product. In particular, the invention relates to a protein that is highly homologous to known interleukin-1 cytokines, nucleic acid molecules that encode such a protein, antibodies that recognize the protein, and methods for diagnosing conditions related to host inflammatory and immune responses.
    Type: Application
    Filed: July 10, 2003
    Publication date: December 2, 2004
    Inventors: Mark A. Labow, Vadim Iourgenko
  • Mammary gland chemokine
    Publication number: 20020009735
    Abstract: The present invention provides various methods for utilizing a polypeptide encoding a chemokine (MEC) and a polypeptide translated therefrom. The MEC chemokine is underexpressed in tumors, making the chemokine a useful marker for diagnosis and prognosis of adverse bodily reactions.
    Type: Application
    Filed: March 21, 2001
    Publication date: January 24, 2002
    Inventors: Mark A. Labow, Craig Stephen Mickanin, Umesh Bhatia
  • Eukaryotic cells comprising a DNA sequence encoding a bacterial-viral chimeric transactivator protein
    Patent number: 5674730
    Abstract: The present invention relates to novel chimeric transactivating proteins comprising a functional portion of a DNA binding protein and a functional portion of a transcriptional activator protein. The chimeric transactivating proteins of the invention offer a variety of advantages, including the specific activation of expression of genes engineered to comprise transactivator responsive elements, thereby achieving exceptionally high levels of gene expression. Furthermore, in various embodiments of the invention, the transactivator proteins may be used to increase expression of some genes while repressing the expression of others, thus permitting a greater degree of control of gene expression patterns than other currently available systems. In preferred embodiments of the invention, the function of the chimeric transactivator proteins may be induced, for example, by chemical agents (e.g. IPTG) or changes in temperature.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: October 7, 1997
    Assignee: The Trustees of Princeton University
    Inventors: Steven B. Baim, Mark A. Labow, Thomas E. Shenk, Arnold J. Levine