Abstract: Provided herein are heavy chain constant regions (referred to as “modified heavy chain constant regions”), or functionally equivalent fragments thereof, that enhance biological properties of antibodies relative to the same antibodies in unmodified form. An exemplary modified heavy chain constant region includes an IgG2 hinge and three constant domains (i.e., CH1, CH2, and CH3 domains), wherein one or more of the constant region domains are of a non-IgG2 isotype (e.g., IgG1, IgG3 or IgG4). The heavy chain constant region may comprise wildtype human IgG domain sequences, or variants of these sequences. Also provided herein are methods for enhancing certain biological properties of antibodies that comprise a non-IgG2 hinge, such as internalization, agonism and antagonism, wherein the method comprises replacing the non-IgG2 hinge of the antibody with an IgG2 hinge.

Abstract: Techniques for authorization are disclosed. In an example, client software executed by a client device receives a first request to access an application within the client software. The client software obtains, from a user of the client device, an authorization to access one or more resources. The client software transmits the authorization to a virtual conference provider. The authorization is associated with the application. The client software launches the application within the client software. The client software receives a second request for authorization from the application. The client software transmits the second request for authorization to the virtual conference provider. The client software receives an authorization response from the virtual conference provider. The client software provides the authorization response to the application.

Abstract: This invention provides a game for one or more players that is played as a game show, as an interactive home computer game, as an interactive on-line game and as a board game. The game challenges players to answer clues in various categories by identifying an answer of one or more words to the clue, wherein each word in the answer consists exclusively of two or more syllables from the syllables provided. The game provides both entertainment and educational value to the players and audience, if present. The invention also provides methods for conducting and playing the game.