Patents by Inventor Mark A. Levy

Mark A. Levy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 17.alpha. and 17.beta.-substituted estra-1,3,5(10)-triene-3-carbboxlic acid
    Patent number: 5618806
    Abstract: Invented are 17.alpha. and 17.beta.-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds. Representative of such compounds include the following ##STR1## wherein Z is .alpha. or .beta. ##STR2## in which A is absent or present as a linear or branched, saturated or unsaturated hydrocarbon chain containing from 1-6 carbon atoms and R isa) a linear or branched, saturated or unsaturated hydrocarbon chain containing 1-12 carbon atoms substituted with one or more substituents selected from the group consisting of: --OC.sub.6 -C.sub.12 aryl, --OC.sub.1 -C.sub.4 alkyl, halogen, carboxy and --S(O).sub.n .sup.R.sup.7, where n is 0-2 and R.sup.7 is hydrogen or C.sub.1-4 alkyl;b) C.sub.3 -C.sub.8 nonaromatic, unsaturated or saturated, cycloalkyl, optionally substituted with one or more substituents selected from the group consisting of:--OC.sub.6 -C.sub.12 aryl, --(CH.sub.2).sub.m OH, --OC.sub.1 -C.sub.4 alkyl, C.sub.6 -C.sub.12 aryl, C.sub.1 -C.sub.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: April 8, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy
  • Reduction of boar odor in meat
    Patent number: 5604214
    Abstract: This invention relates to a method for eliminating or lessening the incidence of boar odor in meat reared from male pigs which comprises administering to such male pigs an effective amount of a boar 4-ene-5-.alpha.-reductase inhibiting compound with or without further active ingredients. Also provided is a method for preventing the formation of 5-.alpha.-androst-16-en-3-one in male pigs which comprises administering to such male pigs a presently discovered boar 4-ene-5-.alpha.-reductase inhibiting compound.
    Type: Grant
    Filed: October 20, 1995
    Date of Patent: February 18, 1997
    Assignee: Pfizer Inc.
    Inventors: Hector W. Alila, Michael T. Clark, Richard D. Hedde, Mark A. Levy, Thomas O. Lindsey
  • 17.alpha. and 17.beta. substituted acyl 4 aza steroids
    Patent number: 5527806
    Abstract: Invented are 17.beta.-substituted acyl-4-aza analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates and processes used in preparing these compounds.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: June 18, 1996
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Hye-Ja Oh
  • Steroid 5-alpha-reductase inhibitors
    Patent number: 5237065
    Abstract: Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.
    Type: Grant
    Filed: February 4, 1992
    Date of Patent: August 17, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
    Patent number: 5137882
    Abstract: Invented are 3-acetic acid-steroidal compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase including using these compounds to reduce prostate size and to treat prostatic adenocarcinoma. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: August 11, 1992
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Intermediates in the preparation of steriod 5-alpha-reductase inhibitors
    Patent number: 5110939
    Abstract: Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.
    Type: Grant
    Filed: October 10, 1989
    Date of Patent: May 5, 1992
    Assignee: Smithkline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-.alpha.-reductase
    Patent number: 5041433
    Abstract: Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase.
    Type: Grant
    Filed: November 1, 1989
    Date of Patent: August 20, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Brian W. Metcalf, Mark A. Levy
  • 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
    Patent number: 5032586
    Abstract: Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are methods for preparing these compounds.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: July 16, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Brian W. Metcalf, Dennis A. Holt, Mark A. Levy
  • Phosphinic acid substituted steroids as inhibitors of steroid 5.alpha.-reductase
    Patent number: 5026882
    Abstract: The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: June 25, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Steriod 5-alpha-reductase inhibitors
    Patent number: 5017568
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: March 23, 1990
    Date of Patent: May 21, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Conrad J. Kowalski, Mark A. Levy, Brian W. Metcalf, Ann M. Tickner
  • 3-substituted nitro-steroid derivatives as 5-.alpha.-reductase inhibitors
    Patent number: 4970204
    Abstract: Invented are 3-nitro- substituted steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: August 23, 1989
    Date of Patent: November 13, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-.alpha.-reductase
    Patent number: 4970205
    Abstract: Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: November 13, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Aromatic steroid 5-.alpha.-reductase inhibitors
    Patent number: 4954446
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: September 4, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Phosphonic acid substituted steroids as steroid 5.alpha.-reductase inhibitors
    Patent number: 4946834
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: August 7, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
    Patent number: 4937237
    Abstract: Invented are phosphinic acid substituted analogues of steroidal synthetic compounds, pharamaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: June 26, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Steroid 5-alpha-reductase inhibitors
    Patent number: 4910226
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: December 1, 1987
    Date of Patent: March 20, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Steroid 5-alpha-reductase inhibitors
    Patent number: 4888336
    Abstract: Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: December 19, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-.alpha.-reductase
    Patent number: 4882319
    Abstract: Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: November 21, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Screen repair
    Patent number: 4222162
    Abstract: A patching system and method for repairing a screen having a defect in it employs two patches interconnectable through the screen in overlying relationship with the defect.
    Type: Grant
    Filed: November 29, 1978
    Date of Patent: September 16, 1980
    Inventors: Mark A. Levy, Jack R. Tester