Patents by Inventor Mark A. NAIVAR
Mark A. NAIVAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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PARTICLE MANIPULATION SYSTEM WITH CYTOMETRIC CAPABILITY AND FEEDBACK LOOP AND VARIABLE GAIN DETECTOR
Publication number: 20240067920Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. One or more feedback loops may be used to improve the particle manipulation process, based on data acquired during the first interrogation and/or during a downstream confirmation. Artificial intelligence techniques may be used to good effect.Type: ApplicationFiled: August 28, 2023Publication date: February 29, 2024Applicant: Owl biomedical, Inc.Inventors: Paul Hing, Nathaniel BAIR, Daryl GRUMMITT, John Harley, Mark NAIVAR, Matthew DICKERSON -
Patent number: 11898954Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.Type: GrantFiled: June 22, 2019Date of Patent: February 13, 2024Assignee: Owl biomedical, Inc.Inventors: John S. Foster, Mark A. Naivar, Kevin E. Shields, Daryl W. Grummitt, Lily Li, Yareeve Zemel
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PARTICLE MANIPULATION SYSTEM WITH CYTOMETRIC CAPABILITY AND FEEDBACK LOOP AND VARIABLE GAIN DETECTOR
Publication number: 20230136744Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. One or more feedback loops may be used to improve the particle manipulation process, based on data acquired during the first interrogation and/or during a downstream confirmation. Artificial intelligence techniques may be used to good effect.Type: ApplicationFiled: November 2, 2022Publication date: May 4, 2023Inventors: Daryl GRUMMITT, Nathan Bair, Matthew Dickerson, John HARLEY, Mark NAIVAR -
Publication number: 20230118941Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. One or more feedback loops may be used to improve the particle manipulation process, based on data acquired during the first interrogation and/or during a downstream confirmation. Artificial intelligence techniques may be used to good effect.Type: ApplicationFiled: November 2, 2022Publication date: April 20, 2023Inventors: Daryl GRUMMITT, John HARLEY, John FOSTER, Mark NAIVAR
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Publication number: 20230124069Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. One or more feedback loops may be used to improve the particle manipulation process, based on data acquired during the first interrogation and/or during a downstream confirmation. Artificial intelligence techniques may be used to good effect.Type: ApplicationFiled: October 14, 2021Publication date: April 20, 2023Inventors: Daryl GRUMMITT, Mehran Hoonejani, Kevin SHIELDS, John HARLEY, Matthew MASON, Mark NAIVAR
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Publication number: 20220260480Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.Type: ApplicationFiled: April 8, 2022Publication date: August 18, 2022Inventors: John S. Foster, Mark A. Naivar, Kevin E. Shields, Daryl W. Grummitt, Timothy J. Wilt, Yareeve Zemel, Lily Li
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Publication number: 20190360915Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.Type: ApplicationFiled: June 22, 2019Publication date: November 28, 2019Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Mark A. NAIVAR, Kevin E. SHIELDS, Daryl W. GRUMMITT, Lily LI, Daryl W. GRUMMITT, Yareeve ZEMEL
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Patent number: 10379030Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.Type: GrantFiled: August 22, 2016Date of Patent: August 13, 2019Assignee: Owl biomedical, Inc.Inventors: John S Foster, Kevin E. Shields, Mehran R. Hoonejani, Mark A. Naivar, Yareeve Zemel
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Patent number: 10132739Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. In the event that the microfabricated particle manipulation device malfunctions as a result of a particle of debris becoming lodged in the microfabricated particle manipulation device, the system may invoke a recovery algorithm, that includes vibrating the microfabricated particle manipulation device using a pulse train at a frequency near its mechanical resonance.Type: GrantFiled: May 20, 2016Date of Patent: November 20, 2018Assignee: Owl biomedical, Inc.Inventors: John Stuart Foster, Kevin Eugene Shields, Mark Naivar, Mehran Rajaian Hoonejani
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Patent number: 9632030Abstract: A method for determining fluorescent lifetime of a fluorescent particle in a flow cytometer comprising calculating a point on a digitized scatter waveform and a corresponding point on a digitized fluorescence waveform using the same method and calculating the time delay if any between the calculated point on the digitized scatter waveform and the calculated point on the fluorescent waveform to determine the fluorescent lifetime of the fluorescent particle with digitized data collected from a flow cytometer having an unmodulated light source.Type: GrantFiled: November 5, 2013Date of Patent: April 25, 2017Assignee: Arrowhead Center, Inc.Inventors: Jessica P. Houston, Mark A. Naivar
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Publication number: 20160377526Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. In the event that the microfabricated particle manipulation device malfunctions as a result of a particle of debris becoming lodged in the microfabricated particle manipulation device, the system may invoke a recovery algorithm, that includes vibrating the microfabricated particle manipulation device using a pulse train at a frequency near its mechanical resonance.Type: ApplicationFiled: May 20, 2016Publication date: December 29, 2016Applicant: Owl biomedical, Inc.Inventors: John Stuart FOSTER, Kevin Eugene SHIELDS, Mark NAIVAR, Mehran Rajaian Hoonejani
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Publication number: 20160377525Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.Type: ApplicationFiled: August 22, 2016Publication date: December 29, 2016Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Kevin E. Shields, Mehran R. Hoonejani, Mark A. NAIVAR, Yareeve ZEMEL